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- W2110346429 abstract "Type 1 diabetes is recognized as an autoimmune inflammatory disease and low grade inflammation is also observed in type 2 diabetic patients. Interleukin 17 (IL-17) is a new player in inflammation. Th17 cells, as the main source of IL-17, require transforming growth factor β (TGF-β) and interleukin 23 (IL-23). The aim of this study was to investigate serum IL-17, IL-23 and TGF-β levels in diabetic patients and controls. In this case-control study, serum levels of IL-17, IL-23, and TGF-β were measured in 24 type 1 diabetic patients and 30 healthy controls using the ELISA method. Simultaneously, the same methodology was used to compare serum concentration of these three cytokines in 38 type 2 diabetic patients and 40 healthy controls. There was no significant difference between serum levels of IL-17 and IL-23 cytokines between cases and controls. However, TGF-β was significantly lower in type 1 diabetic patients (P < 0.001). Serum IL-17 and IL-23 levels demonstrate no association with type 1 and type 2 diabetes, but, in line with previous studies, TGF-β levels were lower in type 1 diabetic patients." @default.
- W2110346429 created "2016-06-24" @default.
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- W2110346429 date "2014-01-01" @default.
- W2110346429 modified "2023-10-16" @default.
- W2110346429 title "Serum IL-17, IL-23, and TGF-<i>β</i>Levels in Type 1 and Type 2 Diabetic Patients and Age-Matched Healthy Controls" @default.
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- W2110346429 doi "https://doi.org/10.1155/2014/718946" @default.
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