FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110346784> ?p ?o ?g. }

• W2110346784 endingPage "539" @default.
• W2110346784 startingPage "533" @default.
• W2110346784 abstract "ABSTRACT Encapsulation of gentamicin in liposomes can be used to achieve intracellular delivery and broaden the clinical utility of this drug. We have previously described a novel, rationally designed, pH-sensitive liposomal carrier for gentamicin that has superior in vitro efficacy against intracellular infections compared to the efficacies of both free gentamicin and non-pH-sensitive liposomal controls. This liposomal carrier demonstrated pH-sensitive fusion that was dependent on the presence of unsaturated phosphatidylethanolamine (PE) and the pH-sensitive lipid N -succinyldioleoyl-PE. The pharmacokinetics and biodistribution of the free and liposomal gentamicin were examined in mice bearing a systemic Salmonella enterica serovar Typhimurium infection. Encapsulation of gentamicin in pH-sensitive liposomes significantly increased the concentrations of the drug in plasma compared to those of free gentamicin. Furthermore, the levels of accumulation of drug in the infected liver and spleen were increased by 153- and 437-fold, respectively, as a result of liposomal encapsulation. The increased accumulation of gentamicin in the liver and spleen effected by liposomal delivery was associated with 10 4 -fold greater antibacterial activity than that associated with free gentamicin in a murine salmonellosis model. These pH-sensitive liposomal antibiotic carriers with enhanced in vitro activity could be used to improve both in vivo intracellular drug delivery and biological activity." @default.
• W2110346784 created "2016-06-24" @default.
• W2110346784 creator A5030919684 @default.
• W2110346784 creator A5042603349 @default.
• W2110346784 creator A5058399005 @default.
• W2110346784 creator A5060066363 @default.
• W2110346784 creator A5060444203 @default.
• W2110346784 creator A5074219555 @default.
• W2110346784 creator A5081029908 @default.
• W2110346784 date "2000-03-01" @default.
• W2110346784 modified "2023-10-17" @default.
• W2110346784 title "Antibacterial Efficacy of Gentamicin Encapsulated in pH-Sensitive Liposomes against an In Vivo <i>Salmonella enterica</i> Serovar Typhimurium Intracellular Infection Model" @default.
• W2110346784 cites W1979980910 @default.
• W2110346784 cites W2048237085 @default.
• W2110346784 cites W2055402663 @default.
• W2110346784 cites W2061337363 @default.
• W2110346784 cites W2062673756 @default.
• W2110346784 cites W2073734538 @default.
• W2110346784 cites W2077224515 @default.
• W2110346784 cites W2106147991 @default.
• W2110346784 cites W2109626244 @default.
• W2110346784 cites W2123463443 @default.
• W2110346784 cites W2143850269 @default.
• W2110346784 cites W2153435210 @default.
• W2110346784 cites W2156373483 @default.
• W2110346784 cites W2318887162 @default.
• W2110346784 doi "https://doi.org/10.1128/aac.44.3.533-539.2000" @default.
• W2110346784 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/89722" @default.
• W2110346784 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10681314" @default.
• W2110346784 hasPublicationYear "2000" @default.
• W2110346784 type Work @default.
• W2110346784 sameAs 2110346784 @default.
• W2110346784 citedByCount "66" @default.
• W2110346784 countsByYear W21103467842012 @default.
• W2110346784 countsByYear W21103467842013 @default.
• W2110346784 countsByYear W21103467842014 @default.
• W2110346784 countsByYear W21103467842015 @default.
• W2110346784 countsByYear W21103467842016 @default.
• W2110346784 countsByYear W21103467842017 @default.
• W2110346784 countsByYear W21103467842018 @default.
• W2110346784 countsByYear W21103467842019 @default.
• W2110346784 countsByYear W21103467842020 @default.
• W2110346784 countsByYear W21103467842021 @default.
• W2110346784 countsByYear W21103467842022 @default.
• W2110346784 countsByYear W21103467842023 @default.
• W2110346784 crossrefType "journal-article" @default.
• W2110346784 hasAuthorship W2110346784A5030919684 @default.
• W2110346784 hasAuthorship W2110346784A5042603349 @default.
• W2110346784 hasAuthorship W2110346784A5058399005 @default.
• W2110346784 hasAuthorship W2110346784A5060066363 @default.
• W2110346784 hasAuthorship W2110346784A5060444203 @default.
• W2110346784 hasAuthorship W2110346784A5074219555 @default.
• W2110346784 hasAuthorship W2110346784A5081029908 @default.
• W2110346784 hasBestOaLocation W21103467842 @default.
• W2110346784 hasConcept C13245373 @default.
• W2110346784 hasConcept C150903083 @default.
• W2110346784 hasConcept C185154212 @default.
• W2110346784 hasConcept C185592680 @default.
• W2110346784 hasConcept C202751555 @default.
• W2110346784 hasConcept C203014093 @default.
• W2110346784 hasConcept C207001950 @default.
• W2110346784 hasConcept C2775832221 @default.
• W2110346784 hasConcept C2777787772 @default.
• W2110346784 hasConcept C2779607309 @default.
• W2110346784 hasConcept C2780035454 @default.
• W2110346784 hasConcept C2780931953 @default.
• W2110346784 hasConcept C2781065037 @default.
• W2110346784 hasConcept C501593827 @default.
• W2110346784 hasConcept C523546767 @default.
• W2110346784 hasConcept C54355233 @default.
• W2110346784 hasConcept C55493867 @default.
• W2110346784 hasConcept C79879829 @default.
• W2110346784 hasConcept C86803240 @default.
• W2110346784 hasConcept C89423630 @default.
• W2110346784 hasConcept C98274493 @default.
• W2110346784 hasConceptScore W2110346784C13245373 @default.
• W2110346784 hasConceptScore W2110346784C150903083 @default.
• W2110346784 hasConceptScore W2110346784C185154212 @default.
• W2110346784 hasConceptScore W2110346784C185592680 @default.
• W2110346784 hasConceptScore W2110346784C202751555 @default.
• W2110346784 hasConceptScore W2110346784C203014093 @default.
• W2110346784 hasConceptScore W2110346784C207001950 @default.
• W2110346784 hasConceptScore W2110346784C2775832221 @default.
• W2110346784 hasConceptScore W2110346784C2777787772 @default.
• W2110346784 hasConceptScore W2110346784C2779607309 @default.
• W2110346784 hasConceptScore W2110346784C2780035454 @default.
• W2110346784 hasConceptScore W2110346784C2780931953 @default.
• W2110346784 hasConceptScore W2110346784C2781065037 @default.
• W2110346784 hasConceptScore W2110346784C501593827 @default.
• W2110346784 hasConceptScore W2110346784C523546767 @default.
• W2110346784 hasConceptScore W2110346784C54355233 @default.
• W2110346784 hasConceptScore W2110346784C55493867 @default.
• W2110346784 hasConceptScore W2110346784C79879829 @default.
• W2110346784 hasConceptScore W2110346784C86803240 @default.
• W2110346784 hasConceptScore W2110346784C89423630 @default.
• W2110346784 hasConceptScore W2110346784C98274493 @default.
• W2110346784 hasIssue "3" @default.
• W2110346784 hasLocation W21103467841 @default.

• next