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- W2110347218 abstract "<h3>OBJECTIVE</h3> To improve the biocompatibility of stents using a phosphorylcholine coated stent as a form of biomimicry. <h3>INTERVENTIONS</h3> Implantation of phosphorylcholine coated (n = 20) and non-coated (n = 21) stents was performed in the coronary arteries of 25 pigs. The animals were killed after five days (n = 6), four weeks (n = 7), and 12 weeks (n = 8), and the vessels harvested for histology, scanning electron microscopy, and morphometry. <h3>MAIN OUTCOME MEASURES</h3> Stent performance was assessed by studying early endothelialisation, neointima formation, and vessel wall reaction to the synthetic coating. <h3>RESULTS</h3> Stent thrombosis did not occur in either group. Morphometry showed no significant differences between the two study groups at any time point. At five days both the coated and non-coated stents were equally well endothelialised (91% <i>v</i>92%, respectively). At four and 12 weeks there was no difference in intimal thickness between the coated and non-coated stents. Up to 12 weeks postimplant the phosphorylcholine coating was still discernible in the stent strut voids, and did not appear to elicit an adverse inflammatory response. <h3>CONCLUSION</h3> In this animal model the phosphorylcholine coating showed excellent blood and tissue compatibility, unlike a number of other polymers tested in a similar setting. Given that the coating was present up to 12 weeks postimplant with no adverse tissue reaction, it may be a potential candidate polymer for local drug delivery." @default.
- W2110347218 created "2016-06-24" @default.
- W2110347218 creator A5038438656 @default.
- W2110347218 date "2000-03-01" @default.
- W2110347218 modified "2023-09-26" @default.
- W2110347218 title "Biocompatibility of phosphorylcholine coated stents in normal porcine coronary arteries" @default.
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- W2110347218 doi "https://doi.org/10.1136/heart.83.3.338" @default.
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