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- W2110348183 abstract "First discovered in the green alga, Chlamydomonas , intraflagellar transport (IFT) is the bidirectional movement of protein particles along the length of eukaryotic cilia and flagella. Composed of ∼16 different proteins, IFT particles are moved out to the distal tip of the organelle by kinesin‐II and are brought back to the cell body by cytoplasmic dynein 1b. Mutant analysis of the IFT motor and particle proteins using diverse organisms has revealed a conserved and essential role for IFT in the assembly and maintenance of cilia and flagella. IFT is thought to mediate this assembly through the delivery of axonemal precursors out to the distal tip of the growing organelle. Consistent with this model, the IFT particle proteins are rich in protein–protein binding motifs, suggesting that the particles may act as scaffolds for the binding of multiple cargoes. With most of the IFT proteins now identified at the level of the gene, this review will briefly examine both the structure and function of the IFT machinery of Chlamydomonas reinhardtii ." @default.
- W2110348183 created "2016-06-24" @default.
- W2110348183 creator A5009589988 @default.
- W2110348183 date "2003-06-09" @default.
- W2110348183 modified "2023-10-15" @default.
- W2110348183 title "The Intraflagellar Transport Machinery of<i>Chlamydomonas reinhardtii</i>" @default.
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- W2110348183 doi "https://doi.org/10.1034/j.1600-0854.2003.t01-1-00103.x" @default.
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