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- W2110348412 abstract "Although the importance of brain trauma as risk factor for the development of epilepsy is well established, the mechanisms of epileptogenesis are not well understood. In the present study, we revealed that the injection of a subthreshold dose of PTZ (30 mg/Kg, i.p.) after 5 weeks of injury induced by Fluid Percussion Brain Injury (FPI) decreased latency for first clonic seizures, increased the time of spent generalized tonic–clonic seizures and electrocorticographic (EEG) wave amplitude. In addition, statistical analysis revealed that N-acetylcysteine (NAC) (100 mg/kg) supplementation during 5 weeks after neuronal injury protected against behavioral and electrographical seizure activity elicited by subthreshold dose of PTZ. The supplementation of this antioxidant compound also protected against the Na+,K+-ATPase activity inhibition and concomitant increase in the levels of oxidative stress markers (protein carbonylation and thiobarbituric acid-reactive substances-TBARS) in site and peri-contusional cortical tissue. In summary, the current experiments clearly showed that FPI model induces early posttraumatic seizures and suggest that an alteration in the lipid/protein oxidation, membrane fluidity, and Na+,K+-ATPase activity may be correlated with neuronal excitability, a significant component of the secondary injury cascade that accompanies TBI." @default.
- W2110348412 created "2016-06-24" @default.
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- W2110348412 date "2011-09-01" @default.
- W2110348412 modified "2023-10-17" @default.
- W2110348412 title "The involvement of Na+, K+-ATPase activity and free radical generation in the susceptibility to pentylenetetrazol-induced seizures after experimental traumatic brain injury" @default.
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- W2110348412 cites W1964004644 @default.
- W2110348412 cites W1967304320 @default.
- W2110348412 cites W1968986651 @default.
- W2110348412 cites W1970516399 @default.
- W2110348412 cites W1970940528 @default.
- W2110348412 cites W1982072755 @default.
- W2110348412 cites W1982854867 @default.
- W2110348412 cites W1983310681 @default.
- W2110348412 cites W1984187734 @default.
- W2110348412 cites W1991838553 @default.
- W2110348412 cites W1996450257 @default.
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- W2110348412 cites W2003975764 @default.
- W2110348412 cites W2004595699 @default.
- W2110348412 cites W2004792176 @default.
- W2110348412 cites W2007743087 @default.
- W2110348412 cites W2011818210 @default.
- W2110348412 cites W2014030060 @default.
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- W2110348412 doi "https://doi.org/10.1016/j.jns.2011.06.030" @default.
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