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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110348886> ?p ?o ?g. }

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• W2110348886 abstract "The investigation of interleukin 1β (IL-1β) in human inflammatory diseases is hampered by the fact that it is virtually undetectable in human plasma. We demonstrate that by administering the anti–human IL-1β antibody canakinumab (ACZ885) to humans, the resulting formation of IL-1β–antibody complexes allowed the detection of in vivo–produced IL-1β. A two-compartment mathematical model was generated that predicted a constitutive production rate of 6 ng/d IL-1β in healthy subjects. In contrast, patients with cryopyrin-associated periodic syndromes (CAPS), a rare monogenetic disease driven by uncontrolled caspase-1 activity and IL-1 production, produced a mean of 31 ng/d. Treatment with canakinumab not only induced long-lasting complete clinical response but also reduced the production rate of IL-1β to normal levels within 8 wk of treatment, suggesting that IL-1β production in these patients was mainly IL-1β driven. The model further indicated that IL-1β is the only cytokine driving disease severity and duration of response to canakinumab. A correction for natural IL-1 antagonists was not required to fit the data. Together, the study allowed new insights into the production and regulation of IL-1β in man. It also indicated that CAPS is entirely mediated by IL-1β and that canakinumab treatment restores physiological IL-1β production." @default.
• W2110348886 created "2016-06-24" @default.
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• W2110348886 date "2009-04-13" @default.
• W2110348886 modified "2023-10-12" @default.
• W2110348886 title "In vivo regulation of interleukin 1β in patients with cryopyrin-associated periodic syndromes" @default.
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• W2110348886 doi "https://doi.org/10.1084/jem.20082481" @default.
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