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• W2110349601 abstract "Self-fertilization is generally seen to be disadvantageous in the long term. It increases genetic drift, which subsequently reduces polymorphism and the efficiency of selection, which also challenges adaptation. However, high selfing rates can increase the fixation probability of recessive beneficial mutations, but existing theory has generally not accounted for the effect of linked sites. Here, we analyze a model for the fixation probability of deleterious mutants that hitchhike with selective sweeps in diploid, partially selfing populations. Approximate analytical solutions show that, conditional on the sweep not being lost by drift, higher inbreeding rates increase the fixation probability of the deleterious allele, due to the resulting reduction in polymorphism and effective recombination. When extending the analysis to consider a distribution of deleterious alleles, as well as the average fitness increase after a sweep, we find that beneficial alleles generally need to be more recessive than the previously assumed dominance threshold (h < 1/2) for selfing to be beneficial from one-locus theory. Our results highlight that recombination aiding the efficiency of selection on multiple loci amplifies the fitness benefits of outcrossing over selfing, compared to results obtained from one-locus theory. This effect additionally increases the parameter range under which obligate outcrossing is beneficial over partial selfing." @default.
• W2110349601 created "2016-06-24" @default.
• W2110349601 creator A5000460408 @default.
• W2110349601 creator A5054940859 @default.
• W2110349601 date "2014-01-01" @default.
• W2110349601 modified "2023-10-04" @default.
• W2110349601 title "Hitchhiking of Deleterious Alleles and the Cost of Adaptation in Partially Selfing Species" @default.
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• W2110349601 doi "https://doi.org/10.1534/genetics.113.158196" @default.
• W2110349601 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3872191" @default.
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• W2110349601 hasPublicationYear "2014" @default.
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