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• W2110351331 startingPage "1581" @default.
• W2110351331 abstract "ABSTRACT The aim of this investigation was to study the effect of polysaccharide capsule on the gene expression in dendritic cells (DC) during their interaction with Cryptococcus neoformans . To this end, we used an encapsulated virulent strain of C. neoformans and a cap59 gene-disrupted acapsular avirulent strain derived from the same genetic background. DC were exposed to encapsulated and acapsular C. neoformans strains for 4 h and 18 h, and their transcriptional profiles were analyzed using the Affymetrix mouse gene chip U74Av2. A large number of DC genes were up-regulated after treatment with the acapsular strain. In particular, we observed the up-regulation of the genes involved in DC maturation, such as cell surface receptors, cytokines, and chemokines (interleukin-12 [IL-12], IL-2, IL-1α, IL-1β, IL-6, IL-10, tumor necrosis factor alpha, CCR7, CCL17, CCL22, CCL3, CCL4, CCL7, and CXCL10), membrane proteins, and the genes involved in antigen processing and presentation as well as cell cycle or apoptosis. The chemokine gene expression data were confirmed by real-time reverse transcription-PCR, while the expression of cytokine genes was correlated with their secretion. A completely different pattern of gene expression was observed for DC treated with an encapsulated strain of C. neoformans . In particular, no significant induction was observed in the expression of the genes mentioned above. Moreover, a number of genes, such as those coding for chemokines, were down-regulated. These results suggest that the polysaccharide capsule shrouding the cell wall of C. neoformans plays a fundamental role in inducing DC response, highlighting the molecular basis of the true nature of immune silencing exerted by capsular material." @default.
• W2110351331 created "2016-06-24" @default.
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• W2110351331 date "2008-04-01" @default.
• W2110351331 modified "2023-10-07" @default.
• W2110351331 title "The Presence of Capsule in <i>Cryptococcus neoformans</i> Influences the Gene Expression Profile in Dendritic Cells during Interaction with the Fungus" @default.
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• W2110351331 doi "https://doi.org/10.1128/iai.01184-07" @default.
• W2110351331 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2292858" @default.
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