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- W2110352413 startingPage "31" @default.
- W2110352413 abstract "This study examines the concept of clinical endocannabinoid deficiency (CECD), and the prospect that it could underlie the pathophysiology of migraine, fibromyalgia, irritable bowel syndrome, and other functional conditions alleviated by clinical cannabis.Available literature was reviewed, and literature searches pursued via the National Library of Medicine database and other resources.Migraine has numerous relationships to endocannabinoid function. Anandamide (AEA) potentiates 5-HT1A and inhibits 5-HT2A receptors supporting therapeutic efficacy in acute and preventive migraine treatment. Cannabinoids also demonstrate dopamine-blocking and anti-inflammatory effects. AEA is tonically active in the periaqueductal gray matter, a migraine generator. THC modulates glutamatergic neurotransmission via NMDA receptors. Fibromyalgia is now conceived as a central sensitization state with secondary hyperalgesia. Cannabinoids have similarly demonstrated the ability to block spinal, peripheral and gastrointestinal mechanisms that promote pain in headache, fibromyalgia, IBS and related disorders. The past and potential clinical utility of cannabis-based medicines in their treatment is discussed, as are further suggestions for experimental investigation of CECD via CSF examination and neuro-imaging.Migraine, fibromyalgia, IBS and related conditions display common clinical, biochemical and pathophysiological patterns that suggest an underlying clinical endocannabinoid deficiency that may be suitably treated with cannabinoid medicines." @default.
- W2110352413 created "2016-06-24" @default.
- W2110352413 creator A5015863091 @default.
- W2110352413 date "2004-05-26" @default.
- W2110352413 modified "2023-09-29" @default.
- W2110352413 title "Clinical endocannabinoid deficiency (CECD): can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions?" @default.
- W2110352413 cites W112764716 @default.
- W2110352413 cites W1551218919 @default.
- W2110352413 cites W1566813966 @default.
- W2110352413 cites W1645449597 @default.
- W2110352413 cites W1683887674 @default.
- W2110352413 cites W1834140965 @default.
- W2110352413 cites W1856242800 @default.
- W2110352413 cites W1886815557 @default.
- W2110352413 cites W1976899484 @default.
- W2110352413 cites W1978952533 @default.
- W2110352413 cites W1979368453 @default.
- W2110352413 cites W1980463442 @default.
- W2110352413 cites W1981252279 @default.
- W2110352413 cites W1981829977 @default.
- W2110352413 cites W1982186440 @default.
- W2110352413 cites W1982291289 @default.
- W2110352413 cites W1984242608 @default.
- W2110352413 cites W1987835057 @default.
- W2110352413 cites W1987931976 @default.
- W2110352413 cites W1989073099 @default.
- W2110352413 cites W1992182049 @default.
- W2110352413 cites W1994807928 @default.
- W2110352413 cites W1995813654 @default.
- W2110352413 cites W1995957231 @default.
- W2110352413 cites W1996397636 @default.
- W2110352413 cites W1997513305 @default.
- W2110352413 cites W1998171066 @default.
- W2110352413 cites W1999667690 @default.
- W2110352413 cites W2001456048 @default.
- W2110352413 cites W2007780291 @default.
- W2110352413 cites W2010606284 @default.
- W2110352413 cites W2011981860 @default.
- W2110352413 cites W2013405740 @default.
- W2110352413 cites W2016438709 @default.
- W2110352413 cites W2017162980 @default.
- W2110352413 cites W2019053800 @default.
- W2110352413 cites W2024653583 @default.
- W2110352413 cites W2024950019 @default.
- W2110352413 cites W2025369248 @default.
- W2110352413 cites W2025862718 @default.
- W2110352413 cites W2030623240 @default.
- W2110352413 cites W2032715817 @default.
- W2110352413 cites W2037043198 @default.
- W2110352413 cites W2040080264 @default.
- W2110352413 cites W2040792219 @default.
- W2110352413 cites W2042751451 @default.
- W2110352413 cites W2043805620 @default.
- W2110352413 cites W2046678517 @default.
- W2110352413 cites W2046945092 @default.
- W2110352413 cites W2048326181 @default.
- W2110352413 cites W2050366726 @default.
- W2110352413 cites W2051332182 @default.
- W2110352413 cites W2052081801 @default.
- W2110352413 cites W2053232832 @default.
- W2110352413 cites W2054729524 @default.
- W2110352413 cites W2057515228 @default.
- W2110352413 cites W2057673987 @default.
- W2110352413 cites W2058013973 @default.
- W2110352413 cites W2060605820 @default.
- W2110352413 cites W2061445816 @default.
- W2110352413 cites W2066366450 @default.
- W2110352413 cites W2067546725 @default.
- W2110352413 cites W2068678080 @default.
- W2110352413 cites W2070569678 @default.
- W2110352413 cites W2074122852 @default.
- W2110352413 cites W2078537805 @default.
- W2110352413 cites W2079878741 @default.
- W2110352413 cites W2087030391 @default.
- W2110352413 cites W2087250130 @default.
- W2110352413 cites W2091572888 @default.
- W2110352413 cites W2094410574 @default.
- W2110352413 cites W2096203089 @default.
- W2110352413 cites W2098443650 @default.
- W2110352413 cites W2102362269 @default.
- W2110352413 cites W2102563706 @default.
- W2110352413 cites W2105024135 @default.
- W2110352413 cites W2109070839 @default.
- W2110352413 cites W2112647660 @default.
- W2110352413 cites W2119898593 @default.
- W2110352413 cites W2122628194 @default.
- W2110352413 cites W2136399145 @default.
- W2110352413 cites W2140086349 @default.
- W2110352413 cites W2140180096 @default.
- W2110352413 cites W2143622186 @default.
- W2110352413 cites W2143719410 @default.
- W2110352413 cites W2148726807 @default.
- W2110352413 cites W2149363030 @default.
- W2110352413 cites W2149381430 @default.
- W2110352413 cites W2149601015 @default.
- W2110352413 cites W2156019215 @default.
- W2110352413 cites W2157518435 @default.
- W2110352413 cites W2165892706 @default.