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• W2110361490 endingPage "561" @default.
• W2110361490 startingPage "554" @default.
• W2110361490 abstract "Processes in the repair of a crevice in the knee joint meniscus were investigated in 10 dogs. Two 2-mm cylindrical plugs from each medial meniscus were removed, rendered acellular by freezing and thawing, and then reinserted into the meniscus. Dogs were euthanized at intervals of 3–52 weeks after surgery. The crevice between the plug and meniscus at 3 weeks after surgery was filled with a tissue containing α-smooth muscle actin-positive cells. One year after surgery, the plug had remodeled and was populated with spindle-shaped and fibrochondrocyte-like cells. The plug had an appearance intermediate between that of hyaline and fibrocartilage at this time, with a seamless integration in sites between the remodeled plug and the surrounding meniscus. α-smooth muscle actin-positive cells were concentrated at the interface of the remodeled plug and adjacent meniscus and at the surface of the plug. Therefore, remodeling of both the plug and meniscal tissue and the participation of α-smooth muscle actin-positive cells appear essential for integration of the plug into the adjacent meniscal tissue. Cells in the superficial zone of the meniscus seem to be active in the repair process. A change in both the phenotype of the cells and the quality of the matrix toward a more hyaline state appears to be an integral part of the remodeling process in the meniscus." @default.
• W2110361490 created "2016-06-24" @default.
• W2110361490 creator A5054469137 @default.
• W2110361490 creator A5059327174 @default.
• W2110361490 creator A5072334592 @default.
• W2110361490 date "2000-11-01" @default.
• W2110361490 modified "2023-10-09" @default.
• W2110361490 title "Cell, matrix changes and alpha-smooth muscle actin expression in repair of the canine meniscus" @default.
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• W2110361490 doi "https://doi.org/10.1046/j.1524-475x.2000.00554.x" @default.
• W2110361490 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11208183" @default.
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