Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110361765> ?p ?o ?g. }
- W2110361765 endingPage "612" @default.
- W2110361765 startingPage "587" @default.
- W2110361765 abstract "AAA+ family proteolytic machines (ClpXP, ClpAP, ClpCP, HslUV, Lon, FtsH, PAN/20S, and the 26S proteasome) perform protein quality control and are used in regulatory circuits in all cells. These machines contain a compartmental protease, with active sites sequestered in an interior chamber, and a hexameric ring of AAA+ ATPases. Substrate proteins are tethered to the ring, either directly or via adaptor proteins. An unstructured region of the substrate is engaged in the axial pore of the AAA+ ring, and cycles of ATP binding/hydrolysis drive conformational changes that create pulses of pulling that denature the substrate and translocate the unfolded polypeptide through the pore and into the degradation chamber. Here, we review our current understanding of the molecular mechanisms of substrate recognition, adaptor function, and ATP-fueled unfolding and translocation. The unfolding activities of these and related AAA+ machines can also be used to disassemble or remodel macromolecular complexes and to resolubilize aggregates." @default.
- W2110361765 created "2016-06-24" @default.
- W2110361765 creator A5012368829 @default.
- W2110361765 creator A5084489456 @default.
- W2110361765 date "2011-07-07" @default.
- W2110361765 modified "2023-10-13" @default.
- W2110361765 title "AAA+ Proteases: ATP-Fueled Machines of Protein Destruction" @default.
- W2110361765 cites W14985340 @default.
- W2110361765 cites W1564936970 @default.
- W2110361765 cites W1571361882 @default.
- W2110361765 cites W1844811650 @default.
- W2110361765 cites W1857769113 @default.
- W2110361765 cites W1875835053 @default.
- W2110361765 cites W1897176773 @default.
- W2110361765 cites W1917978909 @default.
- W2110361765 cites W1947552193 @default.
- W2110361765 cites W1965584194 @default.
- W2110361765 cites W1968330653 @default.
- W2110361765 cites W1969528513 @default.
- W2110361765 cites W1969634682 @default.
- W2110361765 cites W1969894269 @default.
- W2110361765 cites W1970164033 @default.
- W2110361765 cites W1972825620 @default.
- W2110361765 cites W1973086743 @default.
- W2110361765 cites W1974090018 @default.
- W2110361765 cites W1975460230 @default.
- W2110361765 cites W1976196986 @default.
- W2110361765 cites W1978702653 @default.
- W2110361765 cites W1978824717 @default.
- W2110361765 cites W1980534130 @default.
- W2110361765 cites W1981165564 @default.
- W2110361765 cites W1982047570 @default.
- W2110361765 cites W1982488062 @default.
- W2110361765 cites W1982664117 @default.
- W2110361765 cites W1983813028 @default.
- W2110361765 cites W1984777146 @default.
- W2110361765 cites W1985012958 @default.
- W2110361765 cites W1985214621 @default.
- W2110361765 cites W1988419268 @default.
- W2110361765 cites W1992602287 @default.
- W2110361765 cites W1994561051 @default.
- W2110361765 cites W1995673848 @default.
- W2110361765 cites W1996328526 @default.
- W2110361765 cites W1997230834 @default.
- W2110361765 cites W1997978648 @default.
- W2110361765 cites W1998018574 @default.
- W2110361765 cites W1998120967 @default.
- W2110361765 cites W1999119754 @default.
- W2110361765 cites W1999879806 @default.
- W2110361765 cites W2004362709 @default.
- W2110361765 cites W2005030908 @default.
- W2110361765 cites W2007030549 @default.
- W2110361765 cites W2008177707 @default.
- W2110361765 cites W2008207297 @default.
- W2110361765 cites W2008561447 @default.
- W2110361765 cites W2010053404 @default.
- W2110361765 cites W2011074932 @default.
- W2110361765 cites W2012731700 @default.
- W2110361765 cites W2014951926 @default.
- W2110361765 cites W2015408902 @default.
- W2110361765 cites W2015796740 @default.
- W2110361765 cites W2016848577 @default.
- W2110361765 cites W2017056204 @default.
- W2110361765 cites W2020762440 @default.
- W2110361765 cites W2020985890 @default.
- W2110361765 cites W2024582184 @default.
- W2110361765 cites W2028119445 @default.
- W2110361765 cites W2028204392 @default.
- W2110361765 cites W2029171915 @default.
- W2110361765 cites W2031466557 @default.
- W2110361765 cites W2032307617 @default.
- W2110361765 cites W2033575570 @default.
- W2110361765 cites W2038828398 @default.
- W2110361765 cites W2039316348 @default.
- W2110361765 cites W2043712358 @default.
- W2110361765 cites W2045361051 @default.
- W2110361765 cites W2046270751 @default.
- W2110361765 cites W2046381161 @default.
- W2110361765 cites W2048450765 @default.
- W2110361765 cites W2053218983 @default.
- W2110361765 cites W2054030208 @default.
- W2110361765 cites W2054395426 @default.
- W2110361765 cites W2055172284 @default.
- W2110361765 cites W2055544854 @default.
- W2110361765 cites W2057015838 @default.
- W2110361765 cites W2058505635 @default.
- W2110361765 cites W2059029715 @default.
- W2110361765 cites W2059265460 @default.
- W2110361765 cites W2059277971 @default.
- W2110361765 cites W2061721395 @default.
- W2110361765 cites W2062276599 @default.
- W2110361765 cites W2062764590 @default.
- W2110361765 cites W2063306207 @default.
- W2110361765 cites W2066221262 @default.
- W2110361765 cites W2067268586 @default.
- W2110361765 cites W2068297908 @default.
- W2110361765 cites W2069494008 @default.
- W2110361765 cites W2071028051 @default.