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• W2110361885 endingPage "361" @default.
• W2110361885 startingPage "349" @default.
• W2110361885 abstract "This year marks the 50th anniversary of Crick's seminal paper on the packing of alpha-helices into coiled-coil structures. The central tenet of Crick's work is the interdigitation of side chains, which directs the helix-helix interactions; so called knobs-into-holes packing. Subsequent determinations of coiled-coil-protein sequences and structures confirmed the key features of Crick's model and established it as a fundamental concept in structural biology. Recently, we developed a program, SOCKET, to recognise knobs-into-holes packing in protein structures, which we applied to the Protein Data Bank to compile a database of coiled-coil structures. In addition to classic structures, the database reveals 4-helix bundles and larger helical assemblies. Here, we describe how the more-complex structures can be understood by extending Crick's principles for classic coiled coils. In the simplest case, each helix of a 2-stranded structure contributes a single seam of (core) knobs-into-holes to the helical interface. 3-, 4-, and 5-Stranded structures, however, are best considered as rings of helices with cycles of knobs-into-holes. These higher-order oligomers make additional (peripheral) knobs-into-holes that broaden the helical contacts. Combinations of core and peripheral knobs may be assigned to different sequence repeats offset within the same helix. Such multiple repeats lead to multi-faceted helices, which explain structures above dimers. For instance, coiled-coil oligomer state correlates with the offset of the different repeats along a sequence. In addition, certain multi-helix assemblies can be considered as conjoined coiled coils in which multi-faceted helices participate in more than one coiled-coil motif." @default.
• W2110361885 created "2016-06-24" @default.
• W2110361885 creator A5023900250 @default.
• W2110361885 creator A5084275170 @default.
• W2110361885 date "2003-12-01" @default.
• W2110361885 modified "2023-10-16" @default.
• W2110361885 title "Extended knobs-into-holes packing in classical and complex coiled-coil assemblies☆" @default.
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• W2110361885 doi "https://doi.org/10.1016/j.jsb.2003.10.014" @default.
• W2110361885 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14643203" @default.
• W2110361885 hasPublicationYear "2003" @default.
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