FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110361956> ?p ?o ?g. }

• W2110361956 endingPage "354" @default.
• W2110361956 startingPage "347" @default.
• W2110361956 abstract "Abstract —Diverse stimuli, including shear stress, cyclic strain, oxidized LDL, hyperglycemia, and cell growth, modulate endothelial nitric oxide synthase (eNOS) expression. Although seemingly unrelated, these may all alter cellular redox state, suggesting that reactive oxygen intermediates might modulate eNOS expression. The present study was designed to test this hypothesis. Exposure of bovine aortic endothelial cells for 24 hours to paraquat, a superoxide (O 2 −· )–generating compound, did not affect eNOS mRNA levels. However, cotreatment with paraquat and either Cu 2+ /Zn 2+ superoxide dismutase or the superoxide dismutase mimetic tetrakis(4-benzoic acid)porphyrin chloride increased eNOS mRNA by 2.3- and 2.2-fold, respectively, implicating a role for H 2 O 2 . Direct addition of 100 and 150 μmol/L H 2 O 2 caused increases in bovine aortic endothelial cell eNOS mRNA that were dependent on concentration (ie, 3.1- and 5.2-fold increases) and time, and elevated eNOS protein expression and enzyme activity, accordingly. Nuclear run-on and 5,6-dichloro-1-β- d -ribofuranosylbenzimidazole–chase studies showed that H 2 O 2 caused a 3.0-fold increase in eNOS gene transcription and a 2.8-fold increase in eNOS mRNA half-life. Induction of eNOS by H 2 O 2 was not affected by the hydroxyl radical scavenger DMSO, mannitol, or N-tert-butyl -α-phenylnitrone, but it was inhibited by the antioxidants N -acetylcysteine, ebselen, and exogenously added catalase. Unlike H 2 O 2 , the 4.0-fold induction of eNOS by shear stress (15 dyne/cm 2 for 6 hours) was not inhibited by N -acetylcysteine or exogenous catalase. In conclusion, H 2 O 2 increases eNOS expression through transcriptional and post-transcriptional mechanisms. Although H 2 O 2 does not mediate shear-dependent eNOS regulation, it is likely to be involved in regulation of eNOS expression in response to other physiological and/or pathophysiological stimuli." @default.
• W2110361956 created "2016-06-24" @default.
• W2110361956 creator A5011627807 @default.
• W2110361956 creator A5016982755 @default.
• W2110361956 creator A5018191047 @default.
• W2110361956 creator A5020998015 @default.
• W2110361956 creator A5030390724 @default.
• W2110361956 date "2000-02-18" @default.
• W2110361956 modified "2023-10-01" @default.
• W2110361956 title "Transcriptional and Posttranscriptional Regulation of Endothelial Nitric Oxide Synthase Expression by Hydrogen Peroxide" @default.
• W2110361956 cites W1851149345 @default.
• W2110361956 cites W1879535988 @default.
• W2110361956 cites W1918761880 @default.
• W2110361956 cites W1973407863 @default.
• W2110361956 cites W1978099891 @default.
• W2110361956 cites W2001519410 @default.
• W2110361956 cites W2010037068 @default.
• W2110361956 cites W2032769405 @default.
• W2110361956 cites W2040536713 @default.
• W2110361956 cites W2056564646 @default.
• W2110361956 cites W2056604080 @default.
• W2110361956 cites W2091732701 @default.
• W2110361956 cites W2137515520 @default.
• W2110361956 cites W2145150711 @default.
• W2110361956 cites W2158592093 @default.
• W2110361956 cites W2182235855 @default.
• W2110361956 cites W2327589969 @default.
• W2110361956 cites W2412673931 @default.
• W2110361956 doi "https://doi.org/10.1161/01.res.86.3.347" @default.
• W2110361956 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10679488" @default.
• W2110361956 hasPublicationYear "2000" @default.
• W2110361956 type Work @default.
• W2110361956 sameAs 2110361956 @default.
• W2110361956 citedByCount "367" @default.
• W2110361956 countsByYear W21103619562012 @default.
• W2110361956 countsByYear W21103619562013 @default.
• W2110361956 countsByYear W21103619562014 @default.
• W2110361956 countsByYear W21103619562015 @default.
• W2110361956 countsByYear W21103619562016 @default.
• W2110361956 countsByYear W21103619562017 @default.
• W2110361956 countsByYear W21103619562018 @default.
• W2110361956 countsByYear W21103619562019 @default.
• W2110361956 countsByYear W21103619562020 @default.
• W2110361956 countsByYear W21103619562021 @default.
• W2110361956 countsByYear W21103619562022 @default.
• W2110361956 countsByYear W21103619562023 @default.
• W2110361956 crossrefType "journal-article" @default.
• W2110361956 hasAuthorship W2110361956A5011627807 @default.
• W2110361956 hasAuthorship W2110361956A5016982755 @default.
• W2110361956 hasAuthorship W2110361956A5018191047 @default.
• W2110361956 hasAuthorship W2110361956A5020998015 @default.
• W2110361956 hasAuthorship W2110361956A5030390724 @default.
• W2110361956 hasBestOaLocation W21103619561 @default.
• W2110361956 hasConcept C126322002 @default.
• W2110361956 hasConcept C134018914 @default.
• W2110361956 hasConcept C153911025 @default.
• W2110361956 hasConcept C181199279 @default.
• W2110361956 hasConcept C185592680 @default.
• W2110361956 hasConcept C2775838275 @default.
• W2110361956 hasConcept C2776151105 @default.
• W2110361956 hasConcept C2777622882 @default.
• W2110361956 hasConcept C2778326061 @default.
• W2110361956 hasConcept C2778979269 @default.
• W2110361956 hasConcept C2780795997 @default.
• W2110361956 hasConcept C2908688039 @default.
• W2110361956 hasConcept C48349386 @default.
• W2110361956 hasConcept C519581460 @default.
• W2110361956 hasConcept C55493867 @default.
• W2110361956 hasConcept C71924100 @default.
• W2110361956 hasConcept C86803240 @default.
• W2110361956 hasConceptScore W2110361956C126322002 @default.
• W2110361956 hasConceptScore W2110361956C134018914 @default.
• W2110361956 hasConceptScore W2110361956C153911025 @default.
• W2110361956 hasConceptScore W2110361956C181199279 @default.
• W2110361956 hasConceptScore W2110361956C185592680 @default.
• W2110361956 hasConceptScore W2110361956C2775838275 @default.
• W2110361956 hasConceptScore W2110361956C2776151105 @default.
• W2110361956 hasConceptScore W2110361956C2777622882 @default.
• W2110361956 hasConceptScore W2110361956C2778326061 @default.
• W2110361956 hasConceptScore W2110361956C2778979269 @default.
• W2110361956 hasConceptScore W2110361956C2780795997 @default.
• W2110361956 hasConceptScore W2110361956C2908688039 @default.
• W2110361956 hasConceptScore W2110361956C48349386 @default.
• W2110361956 hasConceptScore W2110361956C519581460 @default.
• W2110361956 hasConceptScore W2110361956C55493867 @default.
• W2110361956 hasConceptScore W2110361956C71924100 @default.
• W2110361956 hasConceptScore W2110361956C86803240 @default.
• W2110361956 hasIssue "3" @default.
• W2110361956 hasLocation W21103619561 @default.
• W2110361956 hasLocation W21103619562 @default.
• W2110361956 hasOpenAccess W2110361956 @default.
• W2110361956 hasPrimaryLocation W21103619561 @default.
• W2110361956 hasRelatedWork W115450078 @default.
• W2110361956 hasRelatedWork W2040581652 @default.
• W2110361956 hasRelatedWork W2061409402 @default.
• W2110361956 hasRelatedWork W2088740123 @default.
• W2110361956 hasRelatedWork W2114204950 @default.
• W2110361956 hasRelatedWork W2139861763 @default.

• next