FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110362303> ?p ?o ?g. }

• W2110362303 endingPage "38" @default.
• W2110362303 startingPage "31" @default.
• W2110362303 abstract "Purpose External beam radiation therapy (EBRT) following wide local excision of the primary tumor is the standard treatment in early breast cancer. In some circumstances this procedure is not possible or is contraindicated or difficult. The purpose of this study was to determine the safety and efficacy of targeted intraoperative radiotherapy (TARGIT) when EBRT is not feasible. Methods and Materials We report our experience with TARGIT in three centers (Australia, Germany, and the United Kingdom) between 1999 and 2008. Patients at these centers received a single radiation dose of 20 Gy to the breast tissue in contact with the applicator (or 6 Gy at 1-cm distance), as they could not be given EBRT and were keen to avoid mastectomy. Results Eighty patients were treated with TARGIT. Reasons for using TARGIT were 21 patients had previously received EBRT, and 31 patients had clinical reasons such as systemic lupus erythematosus, motor neuron disease, Parkinson's disease, ankylosing spondylitis, morbid obesity, and cardiovascular or severe respiratory disease. Three of these patients received percutaneous radiotherapy without surgery; 28 patients were included for compelling personal reasons, usually on compassionate grounds. After a median follow-up of 38 months, only two local recurrences were observed, an annual local recurrence rate of 0.75% (95% confidence interval, 0.09%–2.70%). Conclusions While we await the results of the randomized trial (over 2,000 patients have already been recruited), TARGIT is an acceptable option but only in highly selected cases that cannot be recruited in the trial and in whom EBRT is not feasible/possible. External beam radiation therapy (EBRT) following wide local excision of the primary tumor is the standard treatment in early breast cancer. In some circumstances this procedure is not possible or is contraindicated or difficult. The purpose of this study was to determine the safety and efficacy of targeted intraoperative radiotherapy (TARGIT) when EBRT is not feasible. We report our experience with TARGIT in three centers (Australia, Germany, and the United Kingdom) between 1999 and 2008. Patients at these centers received a single radiation dose of 20 Gy to the breast tissue in contact with the applicator (or 6 Gy at 1-cm distance), as they could not be given EBRT and were keen to avoid mastectomy. Eighty patients were treated with TARGIT. Reasons for using TARGIT were 21 patients had previously received EBRT, and 31 patients had clinical reasons such as systemic lupus erythematosus, motor neuron disease, Parkinson's disease, ankylosing spondylitis, morbid obesity, and cardiovascular or severe respiratory disease. Three of these patients received percutaneous radiotherapy without surgery; 28 patients were included for compelling personal reasons, usually on compassionate grounds. After a median follow-up of 38 months, only two local recurrences were observed, an annual local recurrence rate of 0.75% (95% confidence interval, 0.09%–2.70%). While we await the results of the randomized trial (over 2,000 patients have already been recruited), TARGIT is an acceptable option but only in highly selected cases that cannot be recruited in the trial and in whom EBRT is not feasible/possible." @default.
• W2110362303 created "2016-06-24" @default.
• W2110362303 creator A5010375570 @default.
• W2110362303 creator A5014724181 @default.
• W2110362303 creator A5018317908 @default.
• W2110362303 creator A5021116939 @default.
• W2110362303 creator A5034459193 @default.
• W2110362303 creator A5047032886 @default.
• W2110362303 creator A5060216513 @default.
• W2110362303 creator A5081258520 @default.
• W2110362303 creator A5083158555 @default.
• W2110362303 creator A5085733368 @default.
• W2110362303 creator A5090962975 @default.
• W2110362303 date "2011-05-01" @default.
• W2110362303 modified "2023-10-16" @default.
• W2110362303 title "Targeted Intraoperative Radiotherapy for Breast Cancer in Patients in Whom External Beam Radiation Is Not Possible" @default.
• W2110362303 cites W1930328171 @default.
• W2110362303 cites W1934904577 @default.
• W2110362303 cites W1937353240 @default.
• W2110362303 cites W1963769796 @default.
• W2110362303 cites W1982853521 @default.
• W2110362303 cites W1984966852 @default.
• W2110362303 cites W1991734161 @default.
• W2110362303 cites W2018645723 @default.
• W2110362303 cites W2019661342 @default.
• W2110362303 cites W2022730815 @default.
• W2110362303 cites W2035768240 @default.
• W2110362303 cites W2039079413 @default.
• W2110362303 cites W2045929349 @default.
• W2110362303 cites W2047590491 @default.
• W2110362303 cites W2054509904 @default.
• W2110362303 cites W2066664467 @default.
• W2110362303 cites W2066920146 @default.
• W2110362303 cites W2068017316 @default.
• W2110362303 cites W2076090101 @default.
• W2110362303 cites W2085482464 @default.
• W2110362303 cites W2100052191 @default.
• W2110362303 cites W2103771621 @default.
• W2110362303 cites W2119579281 @default.
• W2110362303 cites W2130746306 @default.
• W2110362303 cites W2135979535 @default.
• W2110362303 cites W2140159807 @default.
• W2110362303 cites W2149342403 @default.
• W2110362303 cites W2149955179 @default.
• W2110362303 cites W2158285353 @default.
• W2110362303 cites W2158615473 @default.
• W2110362303 cites W2169949871 @default.
• W2110362303 cites W2171279313 @default.
• W2110362303 cites W2172198909 @default.
• W2110362303 cites W4361745827 @default.
• W2110362303 doi "https://doi.org/10.1016/j.ijrobp.2010.01.045" @default.
• W2110362303 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20646864" @default.
• W2110362303 hasPublicationYear "2011" @default.
• W2110362303 type Work @default.
• W2110362303 sameAs 2110362303 @default.
• W2110362303 citedByCount "35" @default.
• W2110362303 countsByYear W21103623032012 @default.
• W2110362303 countsByYear W21103623032013 @default.
• W2110362303 countsByYear W21103623032014 @default.
• W2110362303 countsByYear W21103623032015 @default.
• W2110362303 countsByYear W21103623032016 @default.
• W2110362303 countsByYear W21103623032017 @default.
• W2110362303 countsByYear W21103623032018 @default.
• W2110362303 countsByYear W21103623032020 @default.
• W2110362303 countsByYear W21103623032021 @default.
• W2110362303 countsByYear W21103623032022 @default.
• W2110362303 crossrefType "journal-article" @default.
• W2110362303 hasAuthorship W2110362303A5010375570 @default.
• W2110362303 hasAuthorship W2110362303A5014724181 @default.
• W2110362303 hasAuthorship W2110362303A5018317908 @default.
• W2110362303 hasAuthorship W2110362303A5021116939 @default.
• W2110362303 hasAuthorship W2110362303A5034459193 @default.
• W2110362303 hasAuthorship W2110362303A5047032886 @default.
• W2110362303 hasAuthorship W2110362303A5060216513 @default.
• W2110362303 hasAuthorship W2110362303A5081258520 @default.
• W2110362303 hasAuthorship W2110362303A5083158555 @default.
• W2110362303 hasAuthorship W2110362303A5085733368 @default.
• W2110362303 hasAuthorship W2110362303A5090962975 @default.
• W2110362303 hasConcept C121608353 @default.
• W2110362303 hasConcept C126322002 @default.
• W2110362303 hasConcept C126838900 @default.
• W2110362303 hasConcept C141071460 @default.
• W2110362303 hasConcept C2775908122 @default.
• W2110362303 hasConcept C2777416452 @default.
• W2110362303 hasConcept C2777757722 @default.
• W2110362303 hasConcept C509974204 @default.
• W2110362303 hasConcept C530470458 @default.
• W2110362303 hasConcept C71924100 @default.
• W2110362303 hasConceptScore W2110362303C121608353 @default.
• W2110362303 hasConceptScore W2110362303C126322002 @default.
• W2110362303 hasConceptScore W2110362303C126838900 @default.
• W2110362303 hasConceptScore W2110362303C141071460 @default.
• W2110362303 hasConceptScore W2110362303C2775908122 @default.
• W2110362303 hasConceptScore W2110362303C2777416452 @default.
• W2110362303 hasConceptScore W2110362303C2777757722 @default.
• W2110362303 hasConceptScore W2110362303C509974204 @default.
• W2110362303 hasConceptScore W2110362303C530470458 @default.
• W2110362303 hasConceptScore W2110362303C71924100 @default.

• next