FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110362570> ?p ?o ?g. }

• W2110362570 endingPage "68" @default.
• W2110362570 startingPage "64" @default.
• W2110362570 abstract "The myelodysplastic syndromes (MDS) are a group of clonal hematopoietic stem cell disorders characterized by ineffective hematopoiesis, peripheral blood cytopenias, dysplasia, and a propensity for transformation to acute myeloid leukemia (AML). A wide spectrum of genetic aberrations has been associated with MDS, including chromosomal translocations involving the NUP98 gene, most commonly leading to fusions of NUP98 with abd-b group HOX genes, including HOXD13. We used vav regulatory elements to direct expression of a NUP98-HOXD13 (NHD13) fusion gene in hematopoietic tissues. NHD13 transgenic mice faithfully recapitulate all the key features of MDS, including peripheral blood cytopenias, bone marrow dysplasia and apoptosis, and transformation to acute leukemia. The MDS that develops in NHD13 transgenic mice is highly lethal; within 14 months, 90% of the mice died of either leukemic transformation or severe anemia and leukopenia due to progressive MDS. These mice provide a preclinical model that can be used for the evaluation of MDS therapy and biology." @default.
• W2110362570 created "2016-06-24" @default.
• W2110362570 creator A5009655674 @default.
• W2110362570 creator A5038002804 @default.
• W2110362570 creator A5049170518 @default.
• W2110362570 creator A5072084058 @default.
• W2110362570 creator A5082376287 @default.
• W2110362570 creator A5090508006 @default.
• W2110362570 date "2008-07-01" @default.
• W2110362570 modified "2023-09-28" @default.
• W2110362570 title "NUP98-HOX Translocations Lead to Myelodysplastic Syndrome in Mice and Men" @default.
• W2110362570 cites W152206099 @default.
• W2110362570 cites W1574742039 @default.
• W2110362570 cites W1967225591 @default.
• W2110362570 cites W1973784728 @default.
• W2110362570 cites W1977937770 @default.
• W2110362570 cites W1992314522 @default.
• W2110362570 cites W2000777582 @default.
• W2110362570 cites W2003173822 @default.
• W2110362570 cites W2016456457 @default.
• W2110362570 cites W2043244689 @default.
• W2110362570 cites W2080015990 @default.
• W2110362570 cites W2080796596 @default.
• W2110362570 cites W2110313909 @default.
• W2110362570 cites W2129446623 @default.
• W2110362570 cites W2133112189 @default.
• W2110362570 cites W2136976836 @default.
• W2110362570 cites W2143500395 @default.
• W2110362570 cites W2162281154 @default.
• W2110362570 cites W3115630352 @default.
• W2110362570 doi "https://doi.org/10.1093/jncimonographs/lgn014" @default.
• W2110362570 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2518060" @default.
• W2110362570 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18648006" @default.
• W2110362570 hasPublicationYear "2008" @default.
• W2110362570 type Work @default.
• W2110362570 sameAs 2110362570 @default.
• W2110362570 citedByCount "29" @default.
• W2110362570 countsByYear W21103625702012 @default.
• W2110362570 countsByYear W21103625702013 @default.
• W2110362570 countsByYear W21103625702014 @default.
• W2110362570 countsByYear W21103625702016 @default.
• W2110362570 countsByYear W21103625702019 @default.
• W2110362570 countsByYear W21103625702020 @default.
• W2110362570 countsByYear W21103625702021 @default.
• W2110362570 countsByYear W21103625702022 @default.
• W2110362570 countsByYear W21103625702023 @default.
• W2110362570 crossrefType "journal-article" @default.
• W2110362570 hasAuthorship W2110362570A5009655674 @default.
• W2110362570 hasAuthorship W2110362570A5038002804 @default.
• W2110362570 hasAuthorship W2110362570A5049170518 @default.
• W2110362570 hasAuthorship W2110362570A5072084058 @default.
• W2110362570 hasAuthorship W2110362570A5082376287 @default.
• W2110362570 hasAuthorship W2110362570A5090508006 @default.
• W2110362570 hasBestOaLocation W21103625701 @default.
• W2110362570 hasConcept C104317684 @default.
• W2110362570 hasConcept C109159458 @default.
• W2110362570 hasConcept C111829193 @default.
• W2110362570 hasConcept C126322002 @default.
• W2110362570 hasConcept C134935766 @default.
• W2110362570 hasConcept C138626823 @default.
• W2110362570 hasConcept C203014093 @default.
• W2110362570 hasConcept C2775894508 @default.
• W2110362570 hasConcept C2776694085 @default.
• W2110362570 hasConcept C2778124228 @default.
• W2110362570 hasConcept C2778274637 @default.
• W2110362570 hasConcept C2778461978 @default.
• W2110362570 hasConcept C2778729363 @default.
• W2110362570 hasConcept C2779282312 @default.
• W2110362570 hasConcept C2780007613 @default.
• W2110362570 hasConcept C2780817109 @default.
• W2110362570 hasConcept C2780873365 @default.
• W2110362570 hasConcept C28328180 @default.
• W2110362570 hasConcept C502942594 @default.
• W2110362570 hasConcept C54355233 @default.
• W2110362570 hasConcept C71924100 @default.
• W2110362570 hasConcept C86803240 @default.
• W2110362570 hasConceptScore W2110362570C104317684 @default.
• W2110362570 hasConceptScore W2110362570C109159458 @default.
• W2110362570 hasConceptScore W2110362570C111829193 @default.
• W2110362570 hasConceptScore W2110362570C126322002 @default.
• W2110362570 hasConceptScore W2110362570C134935766 @default.
• W2110362570 hasConceptScore W2110362570C138626823 @default.
• W2110362570 hasConceptScore W2110362570C203014093 @default.
• W2110362570 hasConceptScore W2110362570C2775894508 @default.
• W2110362570 hasConceptScore W2110362570C2776694085 @default.
• W2110362570 hasConceptScore W2110362570C2778124228 @default.
• W2110362570 hasConceptScore W2110362570C2778274637 @default.
• W2110362570 hasConceptScore W2110362570C2778461978 @default.
• W2110362570 hasConceptScore W2110362570C2778729363 @default.
• W2110362570 hasConceptScore W2110362570C2779282312 @default.
• W2110362570 hasConceptScore W2110362570C2780007613 @default.
• W2110362570 hasConceptScore W2110362570C2780817109 @default.
• W2110362570 hasConceptScore W2110362570C2780873365 @default.
• W2110362570 hasConceptScore W2110362570C28328180 @default.
• W2110362570 hasConceptScore W2110362570C502942594 @default.
• W2110362570 hasConceptScore W2110362570C54355233 @default.
• W2110362570 hasConceptScore W2110362570C71924100 @default.
• W2110362570 hasConceptScore W2110362570C86803240 @default.

• next