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• W2110363029 endingPage "8" @default.
• W2110363029 startingPage "1" @default.
• W2110363029 abstract "P-glycoprotein (P-gp; multidrug resistance pump 1, MDR1; ABCB1) is a plasma membrane efflux pump that when activated in cancer cells exports chemotherapeutic agents. Transcription of the P-gp gene ( MDR1 ) and activity of the P-gp protein are known to be affected by thyroid hormone. A cell surface receptor for thyroid hormone on integrin<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mrow><mml:mi>α</mml:mi></mml:mrow></mml:math>v<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mrow><mml:mi>β</mml:mi></mml:mrow></mml:math>3 also binds tetraiodothyroacetic acid (tetrac), a derivative of L-thyroxine (T 4 ) that blocks nongenomic actions of T 4 and of 3,5,3′-triiodo-L-thyronine (T 3 ) at<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mrow><mml:mi>α</mml:mi></mml:mrow></mml:math>v<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mrow><mml:mi>β</mml:mi></mml:mrow></mml:math>3. Covalently bound to a nanoparticle, tetrac as nanotetrac acts at the integrin to increase intracellular residence time of chemotherapeutic agents such as doxorubicin and etoposide that are substrates of P-gp. This action chemosensitizes cancer cells. In this review, we examine possible molecular mechanisms for the inhibitory effect of nanotetrac on P-gp activity. Mechanisms for consideration include cancer cell acidification via action of tetrac/nanotetrac on the Na + /H + exchanger (NHE1) and hormone analogue effects on calmodulin-dependent processes and on interactions of P-gp with epidermal growth factor (EGF) and osteopontin (OPN), apparently via<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M5><mml:mrow><mml:mi>α</mml:mi></mml:mrow></mml:math>v<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M6><mml:mrow><mml:mi>β</mml:mi></mml:mrow></mml:math>3. Intracellular acidification and decreased H + efflux induced by tetrac/nanotetrac via NHE1 is the most attractive explanation for the actions on P-gp and consequent increase in cancer cell retention of chemotherapeutic agent-ligands of MDR1 protein." @default.
• W2110363029 created "2016-06-24" @default.
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• W2110363029 date "2015-01-01" @default.
• W2110363029 modified "2023-10-15" @default.
• W2110363029 title "Thyroid Hormone and P-Glycoprotein in Tumor Cells" @default.
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• W2110363029 doi "https://doi.org/10.1155/2015/168427" @default.
• W2110363029 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4383522" @default.
• W2110363029 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25866761" @default.
• W2110363029 hasPublicationYear "2015" @default.
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