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- W2110363320 abstract "BACKGROUND: This multicenter, randomized, controlled, double‐blind Phase III clinical study evaluated the therapeutic efficacy and safety of apheresis platelets (PLTs) photochemically treated (PCT) with amotosalen and ultraviolet A light (INTERCEPT Blood System, Baxter Healthcare Corp.) compared with conventional apheresis PLTs (reference). STUDY DESIGN AND METHODS: Forty‐three patients with transfusion‐dependent thrombocytopenia were randomly assigned to receive either PCT or reference PLT transfusions for up to 28 days. RESULTS: The mean 1‐ and 24‐hour corrected count increments were lower in response to PCT PLTs (not significant). When analyzed by longitudinal regression analysis, the estimated effect of treatment on 1‐hour PLT count was a decrease of 7.2 × 10 9 per L (p = 0.05) and on 24‐hour PLT count a decrease of 7.4 × 10 9 per L (p = 0.04). Number, frequency, and dose of PLT transfusions; acute transfusion reactions; and adverse events were similar between the two groups. There was no transfusion‐associated bacteremia. Four PCT patients experienced clinical refractoriness; however, only one exhibited lymphocytotoxicity assay seroconversion. Antibodies against potential amotosalen‐related neoantigens were not detected. CONCLUSION: PCT PLTs provide effective and safe transfusion support for thrombocytopenic patients." @default.
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- W2110363320 date "2005-07-22" @default.
- W2110363320 modified "2023-10-15" @default.
- W2110363320 title "Therapeutic efficacy and safety of photochemically treated apheresis platelets processed with an optimized integrated set" @default.
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- W2110363320 doi "https://doi.org/10.1111/j.1537-2995.2005.00550.x" @default.
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