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• W2110365781 startingPage "634" @default.
• W2110365781 abstract "The focus of tissue engineering of neocartilage has traditionally been on enhancing extracellular matrix and thus biomechanical properties. Emphasis has been placed on the enhancement of collagen type and quantity, and, concomitantly, tensile properties. The objective of this study was to improve crosslinking of the collagen network by testing the hypothesis that hypoxia could promote pyridinoline (PYR) crosslinks and, thus, improve neocartilage's tensile properties.Chondrocyte expression of lysyl oxidase (LOX), an enzyme responsible for the formation of collagen PYR crosslinks, was first assessed pre- and post- hypoxia application. Then, the mechanical properties of self-assembled neocartilage constructs were measured, after 4 weeks of culture, for groups exposed to 4% O2 at different initiation times and durations, i.e., during the 1st and 3rd weeks, 3rd and 4th weeks, 4th week only, continuously after cell seeding, or never.Results showed that LOX gene expression was upregulated ∼20-fold in chondrocytes in response to hypoxia. Hypoxia applied during the 3rd and 4th weeks significantly increased PYR crosslinks without affecting collagen content. Excitingly, neocartilage tensile properties were increased ∼2-fold. It should be noted that these properties exhibited a distinct temporal dependence to hypoxia exposure, since upregulation of these properties was due to hypoxia applied only during the 3rd and 4th weeks.These data elucidate the role of hypoxia-mediated upregulation of LOX and subsequent increases in PYR crosslinks in engineered cartilage. These results hold promise toward applying hypoxia at precise time points to promote tensile integrity and direct construct maturation." @default.
• W2110365781 created "2016-06-24" @default.
• W2110365781 creator A5004589339 @default.
• W2110365781 creator A5026369452 @default.
• W2110365781 creator A5082324061 @default.
• W2110365781 date "2013-04-01" @default.
• W2110365781 modified "2023-10-17" @default.
• W2110365781 title "Hypoxia-induced collagen crosslinking as a mechanism for enhancing mechanical properties of engineered articular cartilage" @default.
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• W2110365781 doi "https://doi.org/10.1016/j.joca.2013.01.007" @default.
• W2110365781 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3670708" @default.
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