FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110366281> ?p ?o ?g. }

• W2110366281 endingPage "787" @default.
• W2110366281 startingPage "776" @default.
• W2110366281 abstract "Eosinophils and T lymphocytes are thought to be involved in allergic airway inflammation. Both cells express the alpha 4 beta 1-integrin, very late antigen-4 (VLA-4, CD49d/CD29); alpha 4-integrins can promote cellular adhesion and activation. Therefore, we examined the in vivo effects of a blocking anti-alpha 4 monoclonal antibody, HP 1/2, on antigen-induced early and late bronchial responses, airway hyperresponsiveness, inflammatory cell influx, and peripheral leukocyte counts in allergic sheep. Sheep blood lymphocytes, monocytes, and eosinophils expressed alpha 4 and bound HP 1/2. In control sheep, Ascaris antigen challenge produced early and late increases in specific lung resistance of 380 +/- 42% and 175 +/- 16% over baseline immediately and 7 h after challenge, respectively, as well as airway hyperresponsiveness continuing for 14 d after antigen challenge. Treatment with HP 1/2 (1 mg/kg, i.v.) 30 min before antigen challenge did not affect the early increase in specific lung resistance but inhibited the late-phase increase at 5-8 h by 75% (P < 0.05) and inhibited the post-antigen-induced airway hyperresponsiveness at 1, 2, 7, and 14 d (P < 0.05, for each time). Intravenous HP 1/2 given 2 h after antigen challenge likewise blocked late-phase airway changes and postchallenge airway hyperresponsiveness. Airway administration of HP 1/2 (16-mg dose) was also effective in blocking these antigen-induced changes. Response to HP 1/2 was specific since an isotypic monoclonal antibody, 1E6, was ineffective by intravenous and aerosol administration. Inhibition of leukocyte recruitment did not totally account for the activity of anti-alpha 4 antibody since HP 1/2 neither diminished the eosinopenia or lymphopenia that followed antigen challenge nor consistently altered the composition of leukocytes recovered by bronchoalveolar lavage. Because airway administration of HP 1/2 was also active, HP 1/2 may have inhibited cell activation. Reduction of platelet-activating factor-induced eosinophil peroxidase release from HP 1/2-treated eosinophils supports such a mechanism. These findings indicate a role for alpha 4-integrins in processes that lead to airway late phase responses and persisting airway hyperresponsiveness after antigen challenge." @default.
• W2110366281 created "2016-06-24" @default.
• W2110366281 creator A5001551598 @default.
• W2110366281 creator A5010673550 @default.
• W2110366281 creator A5011863542 @default.
• W2110366281 creator A5015740336 @default.
• W2110366281 creator A5025196795 @default.
• W2110366281 creator A5061650586 @default.
• W2110366281 creator A5075959769 @default.
• W2110366281 creator A5079457206 @default.
• W2110366281 creator A5082312887 @default.
• W2110366281 creator A5089474779 @default.
• W2110366281 date "1994-02-01" @default.
• W2110366281 modified "2023-10-18" @default.
• W2110366281 title "Alpha 4-integrins mediate antigen-induced late bronchial responses and prolonged airway hyperresponsiveness in sheep." @default.
• W2110366281 cites W14264833 @default.
• W2110366281 cites W1492349213 @default.
• W2110366281 cites W1504413484 @default.
• W2110366281 cites W1519475892 @default.
• W2110366281 cites W1566066927 @default.
• W2110366281 cites W1578883193 @default.
• W2110366281 cites W1811625932 @default.
• W2110366281 cites W1869058799 @default.
• W2110366281 cites W1966903065 @default.
• W2110366281 cites W1973485202 @default.
• W2110366281 cites W1980560159 @default.
• W2110366281 cites W1982821067 @default.
• W2110366281 cites W1984496140 @default.
• W2110366281 cites W1984625946 @default.
• W2110366281 cites W1992999867 @default.
• W2110366281 cites W1995266481 @default.
• W2110366281 cites W2001720727 @default.
• W2110366281 cites W2015037737 @default.
• W2110366281 cites W2018433707 @default.
• W2110366281 cites W2020608323 @default.
• W2110366281 cites W2027401205 @default.
• W2110366281 cites W2045177989 @default.
• W2110366281 cites W2047202466 @default.
• W2110366281 cites W2049841970 @default.
• W2110366281 cites W2052140619 @default.
• W2110366281 cites W2062292756 @default.
• W2110366281 cites W2063872651 @default.
• W2110366281 cites W2069587720 @default.
• W2110366281 cites W2079289760 @default.
• W2110366281 cites W2080195509 @default.
• W2110366281 cites W2085313845 @default.
• W2110366281 cites W2086487142 @default.
• W2110366281 cites W2092868837 @default.
• W2110366281 cites W2095908910 @default.
• W2110366281 cites W2100421481 @default.
• W2110366281 cites W2105807629 @default.
• W2110366281 cites W2116313488 @default.
• W2110366281 cites W2116562044 @default.
• W2110366281 cites W2118769532 @default.
• W2110366281 cites W2128099093 @default.
• W2110366281 cites W2134108209 @default.
• W2110366281 cites W2137394115 @default.
• W2110366281 cites W2137613075 @default.
• W2110366281 cites W2151151601 @default.
• W2110366281 cites W2151235746 @default.
• W2110366281 cites W2153883530 @default.
• W2110366281 cites W2159255305 @default.
• W2110366281 cites W2168456427 @default.
• W2110366281 cites W2288854875 @default.
• W2110366281 cites W2414048923 @default.
• W2110366281 cites W2426880512 @default.
• W2110366281 cites W2470905868 @default.
• W2110366281 cites W47916614 @default.
• W2110366281 doi "https://doi.org/10.1172/jci117032" @default.
• W2110366281 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/293928" @default.
• W2110366281 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8113411" @default.
• W2110366281 hasPublicationYear "1994" @default.
• W2110366281 type Work @default.
• W2110366281 sameAs 2110366281 @default.
• W2110366281 citedByCount "209" @default.
• W2110366281 countsByYear W21103662812012 @default.
• W2110366281 countsByYear W21103662812013 @default.
• W2110366281 countsByYear W21103662812014 @default.
• W2110366281 countsByYear W21103662812015 @default.
• W2110366281 countsByYear W21103662812018 @default.
• W2110366281 countsByYear W21103662812019 @default.
• W2110366281 crossrefType "journal-article" @default.
• W2110366281 hasAuthorship W2110366281A5001551598 @default.
• W2110366281 hasAuthorship W2110366281A5010673550 @default.
• W2110366281 hasAuthorship W2110366281A5011863542 @default.
• W2110366281 hasAuthorship W2110366281A5015740336 @default.
• W2110366281 hasAuthorship W2110366281A5025196795 @default.
• W2110366281 hasAuthorship W2110366281A5061650586 @default.
• W2110366281 hasAuthorship W2110366281A5075959769 @default.
• W2110366281 hasAuthorship W2110366281A5079457206 @default.
• W2110366281 hasAuthorship W2110366281A5082312887 @default.
• W2110366281 hasAuthorship W2110366281A5089474779 @default.
• W2110366281 hasBestOaLocation W21103662811 @default.
• W2110366281 hasConcept C126322002 @default.
• W2110366281 hasConcept C147483822 @default.
• W2110366281 hasConcept C159654299 @default.
• W2110366281 hasConcept C170493617 @default.
• W2110366281 hasConcept C195687474 @default.

• next