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• W2110367311 endingPage "2307" @default.
• W2110367311 startingPage "2290" @default.
• W2110367311 abstract "Reactive oxygen species (ROS), by-products of aerobic metabolism, cause oxidative damage to cells and tissue and not surprisingly many theories have arisen to link ROS-induced oxidative stress to aging and health. While studies clearly link ROS to a plethora of divergent diseases, their role in aging is still debatable. Genetic knock-down manipulations of antioxidants alter the levels of accrued oxidative damage, however, the resultant effect of increased oxidative stress on lifespan are equivocal. Similarly the impact of elevating antioxidant levels through transgenic manipulations yield inconsistent effects on longevity. Furthermore, comparative data from a wide range of endotherms with disparate longevity remain inconclusive. Many long-living species such as birds, bats and mole-rats exhibit high-levels of oxidative damage, evident already at young ages. Clearly, neither the amount of ROS per se nor the sensitivity in neutralizing ROS are as important as whether or not the accrued oxidative stress leads to oxidative-damage-linked age-associated diseases. In this review we examine the literature on ROS, its relation to disease and the lessons gleaned from a comparative approach based upon species with widely divergent responses. We specifically focus on the longest lived rodent, the naked mole-rat, which maintains good health and provides novel insights into the paradox of maintaining both an extended healthspan and lifespan despite high oxidative stress from a young age. Keywords: Comparative biology of aging, mitochondria, naked mole-rat, oxidative stress, proteasome, autophagy, reactive oxygen species, proton motive force, scavengers, Alzheimer's disease" @default.
• W2110367311 created "2016-06-24" @default.
• W2110367311 creator A5005409756 @default.
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• W2110367311 creator A5030863451 @default.
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• W2110367311 creator A5047224964 @default.
• W2110367311 creator A5049047081 @default.
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• W2110367311 creator A5058202537 @default.
• W2110367311 creator A5059841243 @default.
• W2110367311 creator A5091108341 @default.
• W2110367311 date "2011-07-01" @default.
• W2110367311 modified "2023-09-27" @default.
• W2110367311 title "Walking the Oxidative Stress Tightrope: A Perspective from the Naked Mole-Rat, the Longest-Living Rodent" @default.
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