Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110368195> ?p ?o ?g. }
- W2110368195 endingPage "346" @default.
- W2110368195 startingPage "333" @default.
- W2110368195 abstract "The severity of infections caused by the malaria parasite Plasmodium is in part due to the rapid multiplication cycles in the blood of an infected individual. A fundamental step in this phenomenon is the invasion of selected erythrocytes of the host by the parasite. The py235 rhoptry protein multigene family of the rodent malaria parasite Plasmodium yoelii has been implicated in mediating host cell selection during erythrocyte invasion and virulence. Here we show using quantitative real-time polymerase chain reaction and Western blot analysis that variations in the amounts of py235 may be a mechanism that the parasite uses to define its host cell repertoire. High levels of py235 expression leads to a wider range of erythrocytes invaded and therefore increased virulence. In contrast, to evade PY235-specific immunity, the parasite downregulates py235 thereby decreasing the host cell repertoire and virulence. These results demonstrate a new mechanism where variations in the amounts of parasite ligand define the parasite host cell repertoire and enable it to evade host immunity." @default.
- W2110368195 created "2016-06-24" @default.
- W2110368195 creator A5024115309 @default.
- W2110368195 creator A5055147140 @default.
- W2110368195 creator A5080025510 @default.
- W2110368195 creator A5091789536 @default.
- W2110368195 date "2007-06-03" @default.
- W2110368195 modified "2023-10-15" @default.
- W2110368195 title "Variable expression of the 235 kDa rhoptry protein of <i>Plasmodium yoelii</i> mediate host cell adaptation and immune evasion" @default.
- W2110368195 cites W1486229150 @default.
- W2110368195 cites W1502142098 @default.
- W2110368195 cites W1552039422 @default.
- W2110368195 cites W1600207710 @default.
- W2110368195 cites W1646666744 @default.
- W2110368195 cites W1963944184 @default.
- W2110368195 cites W1967863507 @default.
- W2110368195 cites W1968435308 @default.
- W2110368195 cites W1968935058 @default.
- W2110368195 cites W1968981457 @default.
- W2110368195 cites W1971737237 @default.
- W2110368195 cites W1977939138 @default.
- W2110368195 cites W1978153917 @default.
- W2110368195 cites W1981362955 @default.
- W2110368195 cites W1996639655 @default.
- W2110368195 cites W1999584723 @default.
- W2110368195 cites W2002367806 @default.
- W2110368195 cites W2007437580 @default.
- W2110368195 cites W2007705662 @default.
- W2110368195 cites W2026483075 @default.
- W2110368195 cites W2027852704 @default.
- W2110368195 cites W2035183336 @default.
- W2110368195 cites W2039041231 @default.
- W2110368195 cites W2040611232 @default.
- W2110368195 cites W2042818479 @default.
- W2110368195 cites W2045586186 @default.
- W2110368195 cites W2049156626 @default.
- W2110368195 cites W2049408784 @default.
- W2110368195 cites W2064231931 @default.
- W2110368195 cites W2066549809 @default.
- W2110368195 cites W2067926806 @default.
- W2110368195 cites W2070130804 @default.
- W2110368195 cites W2070304025 @default.
- W2110368195 cites W2072404053 @default.
- W2110368195 cites W2072825493 @default.
- W2110368195 cites W2075960831 @default.
- W2110368195 cites W2076171667 @default.
- W2110368195 cites W2076359262 @default.
- W2110368195 cites W2076866468 @default.
- W2110368195 cites W2085020849 @default.
- W2110368195 cites W2095530324 @default.
- W2110368195 cites W2103554667 @default.
- W2110368195 cites W2107794793 @default.
- W2110368195 cites W2110567991 @default.
- W2110368195 cites W2113310648 @default.
- W2110368195 cites W2113657260 @default.
- W2110368195 cites W2118116242 @default.
- W2110368195 cites W2126248785 @default.
- W2110368195 cites W2127291397 @default.
- W2110368195 cites W2128186498 @default.
- W2110368195 cites W2129895984 @default.
- W2110368195 cites W2132078046 @default.
- W2110368195 cites W2141018553 @default.
- W2110368195 cites W2141299037 @default.
- W2110368195 cites W2155340746 @default.
- W2110368195 cites W2161656555 @default.
- W2110368195 cites W2162134485 @default.
- W2110368195 cites W2164536205 @default.
- W2110368195 cites W2168656840 @default.
- W2110368195 cites W2169470106 @default.
- W2110368195 cites W2169829925 @default.
- W2110368195 cites W2171479498 @default.
- W2110368195 cites W2327722450 @default.
- W2110368195 cites W2409710994 @default.
- W2110368195 cites W263504893 @default.
- W2110368195 cites W2896466556 @default.
- W2110368195 cites W4231646317 @default.
- W2110368195 doi "https://doi.org/10.1111/j.1365-2958.2007.05786.x" @default.
- W2110368195 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17590237" @default.
- W2110368195 hasPublicationYear "2007" @default.
- W2110368195 type Work @default.
- W2110368195 sameAs 2110368195 @default.
- W2110368195 citedByCount "42" @default.
- W2110368195 countsByYear W21103681952012 @default.
- W2110368195 countsByYear W21103681952013 @default.
- W2110368195 countsByYear W21103681952015 @default.
- W2110368195 countsByYear W21103681952017 @default.
- W2110368195 countsByYear W21103681952019 @default.
- W2110368195 countsByYear W21103681952020 @default.
- W2110368195 countsByYear W21103681952022 @default.
- W2110368195 countsByYear W21103681952023 @default.
- W2110368195 crossrefType "journal-article" @default.
- W2110368195 hasAuthorship W2110368195A5024115309 @default.
- W2110368195 hasAuthorship W2110368195A5055147140 @default.
- W2110368195 hasAuthorship W2110368195A5080025510 @default.
- W2110368195 hasAuthorship W2110368195A5091789536 @default.
- W2110368195 hasConcept C104317684 @default.
- W2110368195 hasConcept C136764020 @default.
- W2110368195 hasConcept C159047783 @default.