Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110370838> ?p ?o ?g. }
- W2110370838 abstract "MicroRNAs (miRNAs), a class of endogenous small noncoding RNAs, mediate posttranscriptional regulation of protein-coding genes by binding chiefly to the 3’ untranslated region of target mRNAs, leading to translational inhibition, mRNA destabilization or degradation. A single miRNA concurrently downregulates hundreds of target mRNAs designated “targetome”, and thereby fine-tunes gene expression involved in diverse cellular functions, such as development, differentiation, proliferation, apoptosis and metabolism. Recently, we characterized the molecular network of the whole human miRNA targetome by using bioinformatics tools for analyzing molecular interactions on the comprehensive knowledgebase. We found that the miRNA targetome regulated by an individual miRNA generally constitutes the biological network of functionally-associated molecules in human cells, closely linked to pathological events involved in cancers and neurodegenerative diseases. We also identified a collaborative regulation of gene expression by transcription factors and miRNAs in cancer-associated miRNA targetome networks. This review focuses on the workflow of molecular network analysis of miRNA targetome in silico. We applied the workflow to two representative datasets, composed of miRNA expression profiling of adult T cell leukemia (ATL) and Alzheimer’s disease (AD), retrieved from Gene Expression Omnibus (GEO) repository. The results supported the view that miRNAs act as a central regulator of both oncogenesis and neurodegeneration." @default.
- W2110370838 created "2016-06-24" @default.
- W2110370838 creator A5024460308 @default.
- W2110370838 date "2012-10-03" @default.
- W2110370838 modified "2023-10-07" @default.
- W2110370838 title "Molecular network analysis of human microRNA targetome: from cancers to Alzheimer’s disease" @default.
- W2110370838 cites W1500591930 @default.
- W2110370838 cites W1504533062 @default.
- W2110370838 cites W1917905880 @default.
- W2110370838 cites W1967925377 @default.
- W2110370838 cites W1968791377 @default.
- W2110370838 cites W1975744556 @default.
- W2110370838 cites W1976324983 @default.
- W2110370838 cites W1983246703 @default.
- W2110370838 cites W1983804343 @default.
- W2110370838 cites W1998498286 @default.
- W2110370838 cites W2000356500 @default.
- W2110370838 cites W2003449145 @default.
- W2110370838 cites W2007725123 @default.
- W2110370838 cites W2008033547 @default.
- W2110370838 cites W2009787326 @default.
- W2110370838 cites W2013992987 @default.
- W2110370838 cites W2017129209 @default.
- W2110370838 cites W2017270642 @default.
- W2110370838 cites W2022231987 @default.
- W2110370838 cites W2023833090 @default.
- W2110370838 cites W2024527293 @default.
- W2110370838 cites W2026570544 @default.
- W2110370838 cites W2036556087 @default.
- W2110370838 cites W2038886521 @default.
- W2110370838 cites W2044967196 @default.
- W2110370838 cites W2053003053 @default.
- W2110370838 cites W2053490054 @default.
- W2110370838 cites W2053835153 @default.
- W2110370838 cites W2059058316 @default.
- W2110370838 cites W2065566217 @default.
- W2110370838 cites W2066124024 @default.
- W2110370838 cites W2069009920 @default.
- W2110370838 cites W2072484559 @default.
- W2110370838 cites W2074300285 @default.
- W2110370838 cites W2077475358 @default.
- W2110370838 cites W2079929369 @default.
- W2110370838 cites W2089001345 @default.
- W2110370838 cites W2091934374 @default.
- W2110370838 cites W2096367638 @default.
- W2110370838 cites W2101117089 @default.
- W2110370838 cites W2104517740 @default.
- W2110370838 cites W2104806799 @default.
- W2110370838 cites W2109108939 @default.
- W2110370838 cites W2110436540 @default.
- W2110370838 cites W2110666579 @default.
- W2110370838 cites W2111988174 @default.
- W2110370838 cites W2113942490 @default.
- W2110370838 cites W2116075981 @default.
- W2110370838 cites W2116882793 @default.
- W2110370838 cites W2120522615 @default.
- W2110370838 cites W2121629705 @default.
- W2110370838 cites W2126011265 @default.
- W2110370838 cites W2130118447 @default.
- W2110370838 cites W2130122769 @default.
- W2110370838 cites W2130313087 @default.
- W2110370838 cites W2130979840 @default.
- W2110370838 cites W2131880008 @default.
- W2110370838 cites W2133409869 @default.
- W2110370838 cites W2133968430 @default.
- W2110370838 cites W2134118500 @default.
- W2110370838 cites W2136605121 @default.
- W2110370838 cites W2141792156 @default.
- W2110370838 cites W2144896290 @default.
- W2110370838 cites W2150536104 @default.
- W2110370838 cites W2158217645 @default.
- W2110370838 cites W2159857693 @default.
- W2110370838 cites W2160911021 @default.
- W2110370838 cites W2162674813 @default.
- W2110370838 cites W2164483929 @default.
- W2110370838 cites W2164759436 @default.
- W2110370838 cites W2171296186 @default.
- W2110370838 cites W2171437346 @default.
- W2110370838 cites W2171698535 @default.
- W2110370838 cites W2910065277 @default.
- W2110370838 cites W2919705191 @default.
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- W2110370838 doi "https://doi.org/10.1186/1756-0381-5-17" @default.
- W2110370838 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3492042" @default.
- W2110370838 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23034144" @default.
- W2110370838 hasPublicationYear "2012" @default.
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