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• W2110372454 endingPage "635" @default.
• W2110372454 startingPage "623" @default.
• W2110372454 abstract "Abstract We employed quantitative trait locus (QTL) mapping to dissect the genetic architecture of a hierarchy of functionally related physiological traits, including metabolic enzyme activity, metabolite storage, metabolic rate, and free-flight performance in recombinant inbred lines of Drosophila melanogaster. We identified QTL underlying variation in glycogen synthase, hexokinase, phosphoglucomutase, and trehalase activity. In each case variation mapped away from the enzyme-encoding loci, indicating that trans-acting regions of the genome are important sources of variation within the metabolic network. Individual QTL associated with variation in metabolic rate and flight performance explained between 9 and 35% of the phenotypic variance. Bayesian QTL analysis identified epistatic effects underlying variation in flight velocity, metabolic rate, glycogen content, and several metabolic enzyme activities. A region on the third chromosome was associated with expression of the glucose-6-phosphate branchpoint enzymes and with metabolic rate and flight performance. These genomic regions are of special interest as they may coordinately regulate components of energy metabolism with effects on whole-organism physiological performance. The complex biochemical network is encoded by an equally complex network of interacting genetic elements with potentially pleiotropic effects. This has important consequences for the evolution of performance traits that depend upon these metabolic networks." @default.
• W2110372454 created "2016-06-24" @default.
• W2110372454 creator A5006834944 @default.
• W2110372454 creator A5024095588 @default.
• W2110372454 creator A5057537074 @default.
• W2110372454 date "2003-10-01" @default.
• W2110372454 modified "2023-10-11" @default.
• W2110372454 title "Mapping Determinants of Variation in Energy Metabolism, Respiration and Flight in Drosophila" @default.
• W2110372454 cites W107544894 @default.
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• W2110372454 cites W1829144639 @default.
• W2110372454 cites W1846389806 @default.
• W2110372454 cites W1862738799 @default.
• W2110372454 cites W1864995317 @default.
• W2110372454 cites W1894443853 @default.
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• W2110372454 doi "https://doi.org/10.1093/genetics/165.2.623" @default.
• W2110372454 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1462806" @default.
• W2110372454 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14573475" @default.
• W2110372454 hasPublicationYear "2003" @default.
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