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• W2110373212 endingPage "92" @default.
• W2110373212 startingPage "81" @default.
• W2110373212 abstract "The coxsackievirus–adenovirus receptor (CAR) was originally described as a transmembrane protein involved in viral infection and was later found to be required for normal heart development. However, the role of CAR in virus-induced myocarditis has not been investigated so far. The purpose of this study was to assess myocardial CAR expression in response to cytokine-induced inflammatory reactions during the course of coxsackievirus-induced myocarditis. In Balb/c mice intraperitoneally infected with either 2×104 plaque-forming units (PFUs) of coxsackie B3 virus (CVB3) or 102 PFUs CVB3, CAR expression and tyrosine phosphorylation of signal transducer and activator of transcription 1 (STAT1), a known cytokine-inducible transcription factor involved in viral defense, were determined. Our results demonstrated that within the first 7 days after virus inoculation, when the viral replication and STAT1 activation in the heart tissue was most prominent, the expression of CAR did not surpass that of uninfected controls. However, the up-regulation of CAR was observed 9 weeks later, when enteroviral RNA was no longer detectable and activation of STAT1 had already ceased. In contrast to the STAT1 target genes Mig and Irf1, interferon γ stimulation failed to up-regulate Car expression in isolated cardiomyocytes. In human endomyocardial biopsies, Car expression was found to be elevated in approximately one third of patients with dilated cardiomyopathy (9 of 30 patients) as compared with controls. Thus, activation of STAT1 clearly precedes the enhanced CAR expression observed during tissue reorganization, suggesting an essential role of STAT1 transcription factors in orchestrating the sequential actions involved in adaptive immune response." @default.
• W2110373212 created "2016-06-24" @default.
• W2110373212 creator A5008038627 @default.
• W2110373212 creator A5008383215 @default.
• W2110373212 creator A5022754351 @default.
• W2110373212 creator A5025585953 @default.
• W2110373212 creator A5081378662 @default.
• W2110373212 date "2008-03-01" @default.
• W2110373212 modified "2023-10-02" @default.
• W2110373212 title "Activation of STAT1 transcription factor precedes up-regulation of coxsackievirus–adenovirus receptor during viral myocarditis" @default.
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• W2110373212 doi "https://doi.org/10.1016/j.carpath.2007.07.004" @default.
• W2110373212 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18329552" @default.
• W2110373212 hasPublicationYear "2008" @default.
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