FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110384113> ?p ?o ?g. }

• W2110384113 endingPage "4115" @default.
• W2110384113 startingPage "4110" @default.
• W2110384113 abstract "Increased kynurenine pathway metabolism has been implicated in the etiology of AIDS dementia complex (ADC). The rate-limiting enzyme for this pathway is indolamine 2,3-dioxygenase (IDO). We tested the efficacy of different strains of human immunodeficiency virus type 1 (HIV1-BaL, HIV1-JRFL, and HIV1-631) to induce IDO in cultured human monocyte-derived macrophages (MDM). A significant increase in both IDO protein and kynurenine synthesis was observed after 48 h in MDM infected with the brain-derived HIV-1 isolates, laboratory-adapted (LA) HIV1-JRFL, and primary isolate HIV1-631. In contrast, almost no kynurenine production or IDO protein was evident in MDM infected with the highly replicating macrophage-tropic LA strain HIV1-BaL. The induction of IDO and kynurenine synthesis by HIV1-JRFL and HIV1-631 declined to baseline levels by day 8 postinfection. Abundant HIV-1 replication did not reduce the ability of exogenous gamma interferon (IFN-gamma) to induce IDO and kynurenine synthesis in HIV-infected MDM. The addition of anti-IFN-gamma antibody to MDM infected with HIV1-JRFL resulted in an absence of detectable IDO protein after 48 h and a decrease of 64% +/- 1% in supernatant kynurenine concentration. Together, these results indicate that only selected strains of HIV-1 are capable of inducing IDO synthesis and subsequent kynurenine metabolism in MDM. The induction of IDO, while apparently independent of replication capacity, appears to be mediated by a transient production of IFN-gamma in MDM responding to the initial infection with selected strains of HIV-1." @default.
• W2110384113 created "2016-06-24" @default.
• W2110384113 creator A5017219785 @default.
• W2110384113 creator A5022233013 @default.
• W2110384113 creator A5026553554 @default.
• W2110384113 creator A5047508507 @default.
• W2110384113 creator A5050094089 @default.
• W2110384113 creator A5079957640 @default.
• W2110384113 creator A5091912064 @default.
• W2110384113 date "2000-05-01" @default.
• W2110384113 modified "2023-10-09" @default.
• W2110384113 title "Induction of Indolamine 2,3-Dioxygenase in Primary Human Macrophages by Human Immunodeficiency Virus Type 1 Is Strain Dependent" @default.
• W2110384113 cites W1484692085 @default.
• W2110384113 cites W1505072916 @default.
• W2110384113 cites W1525259648 @default.
• W2110384113 cites W1582483157 @default.
• W2110384113 cites W1782672155 @default.
• W2110384113 cites W1915828783 @default.
• W2110384113 cites W1936351921 @default.
• W2110384113 cites W1963855922 @default.
• W2110384113 cites W1980613104 @default.
• W2110384113 cites W1987547165 @default.
• W2110384113 cites W1987984478 @default.
• W2110384113 cites W1990965304 @default.
• W2110384113 cites W1994499722 @default.
• W2110384113 cites W1998990074 @default.
• W2110384113 cites W2000336468 @default.
• W2110384113 cites W2003823779 @default.
• W2110384113 cites W2018073475 @default.
• W2110384113 cites W2022770520 @default.
• W2110384113 cites W2057471935 @default.
• W2110384113 cites W2059253537 @default.
• W2110384113 cites W2062152625 @default.
• W2110384113 cites W2066121768 @default.
• W2110384113 cites W2077290004 @default.
• W2110384113 cites W2086494057 @default.
• W2110384113 cites W2087539536 @default.
• W2110384113 cites W2087798692 @default.
• W2110384113 cites W2089074317 @default.
• W2110384113 cites W2092580120 @default.
• W2110384113 cites W2096750803 @default.
• W2110384113 cites W2097972613 @default.
• W2110384113 cites W2103365659 @default.
• W2110384113 cites W2120606210 @default.
• W2110384113 cites W2131203239 @default.
• W2110384113 cites W2146901670 @default.
• W2110384113 cites W2150627157 @default.
• W2110384113 cites W2152611825 @default.
• W2110384113 cites W2155117467 @default.
• W2110384113 cites W2168198521 @default.
• W2110384113 cites W2187650897 @default.
• W2110384113 cites W81787405 @default.
• W2110384113 doi "https://doi.org/10.1128/jvi.74.9.4110-4115.2000" @default.
• W2110384113 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/111925" @default.
• W2110384113 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10756023" @default.
• W2110384113 hasPublicationYear "2000" @default.
• W2110384113 type Work @default.
• W2110384113 sameAs 2110384113 @default.
• W2110384113 citedByCount "67" @default.
• W2110384113 countsByYear W21103841132012 @default.
• W2110384113 countsByYear W21103841132013 @default.
• W2110384113 countsByYear W21103841132014 @default.
• W2110384113 countsByYear W21103841132015 @default.
• W2110384113 countsByYear W21103841132016 @default.
• W2110384113 countsByYear W21103841132017 @default.
• W2110384113 countsByYear W21103841132019 @default.
• W2110384113 countsByYear W21103841132022 @default.
• W2110384113 crossrefType "journal-article" @default.
• W2110384113 hasAuthorship W2110384113A5017219785 @default.
• W2110384113 hasAuthorship W2110384113A5022233013 @default.
• W2110384113 hasAuthorship W2110384113A5026553554 @default.
• W2110384113 hasAuthorship W2110384113A5047508507 @default.
• W2110384113 hasAuthorship W2110384113A5050094089 @default.
• W2110384113 hasAuthorship W2110384113A5079957640 @default.
• W2110384113 hasAuthorship W2110384113A5091912064 @default.
• W2110384113 hasBestOaLocation W21103841132 @default.
• W2110384113 hasConcept C106358424 @default.
• W2110384113 hasConcept C140704245 @default.
• W2110384113 hasConcept C159047783 @default.
• W2110384113 hasConcept C159654299 @default.
• W2110384113 hasConcept C203014093 @default.
• W2110384113 hasConcept C2522874641 @default.
• W2110384113 hasConcept C2776178377 @default.
• W2110384113 hasConcept C2776706248 @default.
• W2110384113 hasConcept C2776710720 @default.
• W2110384113 hasConcept C2777503454 @default.
• W2110384113 hasConcept C515207424 @default.
• W2110384113 hasConcept C54355233 @default.
• W2110384113 hasConcept C55493867 @default.
• W2110384113 hasConcept C81885089 @default.
• W2110384113 hasConcept C83478079 @default.
• W2110384113 hasConcept C86803240 @default.
• W2110384113 hasConceptScore W2110384113C106358424 @default.
• W2110384113 hasConceptScore W2110384113C140704245 @default.
• W2110384113 hasConceptScore W2110384113C159047783 @default.
• W2110384113 hasConceptScore W2110384113C159654299 @default.
• W2110384113 hasConceptScore W2110384113C203014093 @default.
• W2110384113 hasConceptScore W2110384113C2522874641 @default.

• next