FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110391731> ?p ?o ?g. }

• W2110391731 endingPage "1007" @default.
• W2110391731 startingPage "1002" @default.
• W2110391731 abstract "Lipoprotein lipase has been considered as the only enzyme capable of generating lipid-derived fatty acids for cardiac energy. Endothelial lipase is another member of the triglyceride lipase family and hydrolyzes high-density lipoproteins. Although endothelial lipase is expressed in the heart, its function remains unclear. We assessed the role of endothelial lipase in the genesis of heart failure. Pressure overload-induced cardiac hypertrophy was generated in endothelial lipase(-/-) and wild-type mice by ascending aortic banding. Endothelial lipase expression in cardiac tissues was markedly elevated in the early phase of cardiac hypertrophy in wild-type mice, whereas lipoprotein lipase expression was significantly reduced. Endothelial lipase(-/-) mice showed more severe systolic dysfunction with left-ventricular dilatation compared with wild-type mice in response to pressure overload. The expression of mitochondrial fatty acid oxidation-related genes, such as carnitine palmitoyltransferase-1 and medium-chain acyl coenzyme A dehydrogenase, was significantly lower in the heart of endothelial lipase(-/-) mice than in wild-type mice. Also, endothelial lipase(-/-) mice had lower myocardial adenosine triphosphate levels than wild-type mice after aortic banding. In cultured cardiomyocytes, endothelial lipase was upregulated by inflammatory stimuli, whereas lipoprotein lipase was downregulated. Endothelial lipase-overexpression in cardiomyocytes resulted in an upregulation of fatty acid oxidation-related enzymes and intracellular adenosine triphosphate accumulation in the presence of high-density lipoprotein. Endothelial lipase may act as an alternative candidate to provide fatty acids to the heart and regulate cardiac function. This effect seemed relevant particularly in the diseased heart, where lipoprotein lipase action is downregulated." @default.
• W2110391731 created "2016-06-24" @default.
• W2110391731 creator A5017027780 @default.
• W2110391731 creator A5017514518 @default.
• W2110391731 creator A5032646427 @default.
• W2110391731 creator A5033044041 @default.
• W2110391731 creator A5064322654 @default.
• W2110391731 creator A5064923028 @default.
• W2110391731 creator A5068690527 @default.
• W2110391731 creator A5069141136 @default.
• W2110391731 creator A5074352632 @default.
• W2110391731 creator A5082647122 @default.
• W2110391731 creator A5087872679 @default.
• W2110391731 date "2013-05-01" @default.
• W2110391731 modified "2023-10-18" @default.
• W2110391731 title "Endothelial Lipase Modulates Pressure Overload–Induced Heart Failure Through Alternative Pathway for Fatty Acid Uptake" @default.
• W2110391731 cites W1939640254 @default.
• W2110391731 cites W1977666051 @default.
• W2110391731 cites W1988064154 @default.
• W2110391731 cites W2020464685 @default.
• W2110391731 cites W2024557569 @default.
• W2110391731 cites W2034075895 @default.
• W2110391731 cites W2038872048 @default.
• W2110391731 cites W2053081403 @default.
• W2110391731 cites W2063594418 @default.
• W2110391731 cites W2074350515 @default.
• W2110391731 cites W2103634232 @default.
• W2110391731 cites W2105724958 @default.
• W2110391731 cites W2120240698 @default.
• W2110391731 cites W2122963423 @default.
• W2110391731 cites W2130508617 @default.
• W2110391731 cites W2131578695 @default.
• W2110391731 cites W2135130550 @default.
• W2110391731 cites W2150197543 @default.
• W2110391731 cites W2152700329 @default.
• W2110391731 cites W2160000314 @default.
• W2110391731 cites W2203481725 @default.
• W2110391731 cites W2302620494 @default.
• W2110391731 cites W2321985583 @default.
• W2110391731 cites W4231157482 @default.
• W2110391731 doi "https://doi.org/10.1161/hypertensionaha.111.201608" @default.
• W2110391731 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23460280" @default.
• W2110391731 hasPublicationYear "2013" @default.
• W2110391731 type Work @default.
• W2110391731 sameAs 2110391731 @default.
• W2110391731 citedByCount "18" @default.
• W2110391731 countsByYear W21103917312013 @default.
• W2110391731 countsByYear W21103917312014 @default.
• W2110391731 countsByYear W21103917312015 @default.
• W2110391731 countsByYear W21103917312016 @default.
• W2110391731 countsByYear W21103917312017 @default.
• W2110391731 countsByYear W21103917312018 @default.
• W2110391731 countsByYear W21103917312019 @default.
• W2110391731 countsByYear W21103917312020 @default.
• W2110391731 countsByYear W21103917312022 @default.
• W2110391731 crossrefType "journal-article" @default.
• W2110391731 hasAuthorship W2110391731A5017027780 @default.
• W2110391731 hasAuthorship W2110391731A5017514518 @default.
• W2110391731 hasAuthorship W2110391731A5032646427 @default.
• W2110391731 hasAuthorship W2110391731A5033044041 @default.
• W2110391731 hasAuthorship W2110391731A5064322654 @default.
• W2110391731 hasAuthorship W2110391731A5064923028 @default.
• W2110391731 hasAuthorship W2110391731A5068690527 @default.
• W2110391731 hasAuthorship W2110391731A5069141136 @default.
• W2110391731 hasAuthorship W2110391731A5074352632 @default.
• W2110391731 hasAuthorship W2110391731A5082647122 @default.
• W2110391731 hasAuthorship W2110391731A5087872679 @default.
• W2110391731 hasBestOaLocation W21103917311 @default.
• W2110391731 hasConcept C126322002 @default.
• W2110391731 hasConcept C134018914 @default.
• W2110391731 hasConcept C167414201 @default.
• W2110391731 hasConcept C171089720 @default.
• W2110391731 hasConcept C181199279 @default.
• W2110391731 hasConcept C185592680 @default.
• W2110391731 hasConcept C2778271984 @default.
• W2110391731 hasConcept C2779697368 @default.
• W2110391731 hasConcept C3018791406 @default.
• W2110391731 hasConcept C543025807 @default.
• W2110391731 hasConcept C55493867 @default.
• W2110391731 hasConcept C71924100 @default.
• W2110391731 hasConcept C86803240 @default.
• W2110391731 hasConcept C94879076 @default.
• W2110391731 hasConceptScore W2110391731C126322002 @default.
• W2110391731 hasConceptScore W2110391731C134018914 @default.
• W2110391731 hasConceptScore W2110391731C167414201 @default.
• W2110391731 hasConceptScore W2110391731C171089720 @default.
• W2110391731 hasConceptScore W2110391731C181199279 @default.
• W2110391731 hasConceptScore W2110391731C185592680 @default.
• W2110391731 hasConceptScore W2110391731C2778271984 @default.
• W2110391731 hasConceptScore W2110391731C2779697368 @default.
• W2110391731 hasConceptScore W2110391731C3018791406 @default.
• W2110391731 hasConceptScore W2110391731C543025807 @default.
• W2110391731 hasConceptScore W2110391731C55493867 @default.
• W2110391731 hasConceptScore W2110391731C71924100 @default.
• W2110391731 hasConceptScore W2110391731C86803240 @default.
• W2110391731 hasConceptScore W2110391731C94879076 @default.
• W2110391731 hasIssue "5" @default.
• W2110391731 hasLocation W21103917311 @default.

• next