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- W2110402932 abstract "ABSTRACT Myxococcus xanthus cells carrying the Ω4408 Tn 5lac insertion at the sde locus show defects in fruiting body development and sporulation. Our analysis of sde expression patterns showed that this locus is induced early in the developmental program (0 to 2 h) and that expression increases approximately fivefold after 12 h of development. Further studies showed that expression of sde is induced as growing cells enter stationary phase, suggesting that activation of the sde locus is not limited to the developmental process. Because the peak levels of sde expression in both an sde + and an sde mutant background were similar, we conclude that the sde locus is not autoregulated. Characterization of the sde locus by DNA sequence analysis indicated that the Ω4408 insertion occurred within the sdeK gene. Primer extension analyses localized the 5′ end of sde transcript to a guanine nucleotide 307 bp upstream of the proposed start for the SdeK coding sequence. The DNA sequence in the −12 and −24 regions upstream of the sde transcriptional start site shows similarity to the ς 54 family of promoters. The results of complementation studies suggest that the defects in development and sporulation caused by the Ω4408 insertion are due to an inactivation of sdeK . The predicted amino acid sequence of SdeK was found to have similarity to the sequences of the histidine protein kinases of two-component regulatory systems. Based on our results, we propose that SdeK may be part of a signal transduction pathway required for the activation and propagation of the early developmental program." @default.
- W2110402932 created "2016-06-24" @default.
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- W2110402932 date "1998-09-01" @default.
- W2110402932 modified "2023-10-15" @default.
- W2110402932 title "SdeK Is Required for Early Fruiting Body Development in Myxococcus xanthus" @default.
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- W2110402932 doi "https://doi.org/10.1128/jb.180.17.4628-4637.1998" @default.
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