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• W2110404902 abstract "We studied the effects of Al and Fe on bone metabolism in vivo and in vitro using nitrilotriacetic acid (NTA) as a chelator. We have reported experimental osteopathy in growing rats (6 weeks). In the present study, we used adult Wistar rats (15 weeks). Both Al-NTA (3.0 mg Al/kg) and Fe-NTA (6.0 mg Fe/kg) caused renal insufficiency and osteomalacia. Osteoid volume was 65.79±5.25% in Al-treated rats, 3.97±2.25% in Fe-treated rats and 2.22±0.77% in the control rats. The impairment of bone mineralization was detected in Al- and Fe-treated rats. The osteoidosis induced by Al-NTA in adult rats was much more severe than that in growing rats. Osteomalacia was not induced by Fe-NTA in growing rats, but moderate osteomalacia was induced in adult rats. Therefore, an age-related change of the bone metabolism was suggested. The direct effects of these metals were also examined using an osteoblast-like cell line (HuO9) in vitro. The collagen synthesis was kept constant between Al and Fe concentration of 10−6 and 10−4 M, although ALP activity was decreased by Al and Fe. The results of this study demonstrate that Al- and Fe-NTA have negative effects on bone formation in vivo and in vitro, and that they are useful for experimental models of mineral induced osteomalacia." @default.
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• W2110404902 date "1997-06-01" @default.
• W2110404902 modified "2023-09-25" @default.
• W2110404902 title "The inhibitory effects of aluminum and iron on bone formation, in vivo and in vitro study" @default.
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• W2110404902 doi "https://doi.org/10.1016/s0928-4680(97)00164-8" @default.
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