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- W2110404966 abstract "Cor pulmonale has long been described in very severe chronic obstructive pulmonary disease (COPD) and emphysema. Cross-sectional results from population-based studies show that left ventricular filling and a variety of vascular measures in the systemic circulation are abnormal in preclinical COPD and emphysema and that a predominant vascular change in COPD and emphysema is endothelial and microvascular dysfunction. These findings suggest that pulmonary vascular changes may occur early in COPD and emphysema and might contribute to pathogenesis. However, longitudinal epidemiologic studies with direct measures of the pulmonary vasculature are lacking; therefore, inferences are limited at present. New imaging-based approaches to the assessment of the pulmonary vasculature are applicable to epidemiologic studies and may help in defining the relationship of pulmonary vascular damage to progression of COPD and emphysema. These measures may also provide imaging-based surrogate markers, and novel therapeutics targeted to the pulmonary vasculature might reduce symptoms and improve function in these common diseases." @default.
- W2110404966 created "2016-06-24" @default.
- W2110404966 creator A5067983207 @default.
- W2110404966 date "2011-11-01" @default.
- W2110404966 modified "2023-10-16" @default.
- W2110404966 title "The Epidemiology of Vascular Dysfunction Relating to Chronic Obstructive Pulmonary Disease and Emphysema" @default.
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- W2110404966 doi "https://doi.org/10.1513/pats.201101-008mw" @default.
- W2110404966 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3359073" @default.
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