FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110406916> ?p ?o ?g. }

• W2110406916 endingPage "4522" @default.
• W2110406916 startingPage "4513" @default.
• W2110406916 abstract "Regeneration of spinal cord injury (SCI) is a major topic of biomedical research. Laminin is an extracellular matrix protein implicated in neural development and regeneration, but despite that, there are no reports of exogenous laminin contributing to improve the outcome of experimental SCI. Here we investigated whether a biomimetic polymer of laminin assembled on pH acidification, henceforth called polylaminin, could be used to treat SCI in rats. Acute local injection of polylaminin, but not of nonpolymerized laminin, improved motor function after thoracic compression, partial or complete transection. In the latter case, the BBB score for open field locomotion 8 wk after lesion increased from 4.2 ± 0.48 to 8.8 ± 1.14 in animals treated with polylaminin of human origin. Accordingly, neurons retrogradely labeled from the sublesion stump were detected in the spinal cord and brain stem, indicating regrowth of short and long fibers across a complete transection. Polylaminin also played an unsuspected anti-inflammatory role, which underlies the early onset of its positive effects on locomotion from the first week after treatment. The beneficial effects of polylaminin were not observed in animals treated with the nonpolymerized protein or vehicle only. We propose that polylaminin is a promising therapeutic agent to treat human SCI.—Menezes, K., Menezes, J. R. L., Nascimento, M. A., Siqueira Santos, R., Coelho-Sampaio, T. Polylaminin, a polymeric form of laminin, promotes regeneration after spinal cord injury. FASEB J. 24, 4513–4522 (2010). www.fasebj.org" @default.
• W2110406916 created "2016-06-24" @default.
• W2110406916 creator A5028253550 @default.
• W2110406916 creator A5041122525 @default.
• W2110406916 creator A5053499233 @default.
• W2110406916 creator A5076658467 @default.
• W2110406916 creator A5089510225 @default.
• W2110406916 date "2010-07-19" @default.
• W2110406916 modified "2023-09-24" @default.
• W2110406916 title "Polylaminin, a polymeric form of laminin, promotes regeneration after spinal cord injury" @default.
• W2110406916 cites W138027414 @default.
• W2110406916 cites W1506438655 @default.
• W2110406916 cites W1507170913 @default.
• W2110406916 cites W1930709195 @default.
• W2110406916 cites W1963586813 @default.
• W2110406916 cites W1967607435 @default.
• W2110406916 cites W1969850343 @default.
• W2110406916 cites W1975724680 @default.
• W2110406916 cites W1983161704 @default.
• W2110406916 cites W1983712592 @default.
• W2110406916 cites W1985300485 @default.
• W2110406916 cites W1988092054 @default.
• W2110406916 cites W1993376226 @default.
• W2110406916 cites W1993743744 @default.
• W2110406916 cites W2000426718 @default.
• W2110406916 cites W2006501418 @default.
• W2110406916 cites W2006831658 @default.
• W2110406916 cites W2009191172 @default.
• W2110406916 cites W2023053568 @default.
• W2110406916 cites W2028637089 @default.
• W2110406916 cites W2030927825 @default.
• W2110406916 cites W2035527556 @default.
• W2110406916 cites W2038344135 @default.
• W2110406916 cites W2057502749 @default.
• W2110406916 cites W2062366535 @default.
• W2110406916 cites W2063743512 @default.
• W2110406916 cites W2084904109 @default.
• W2110406916 cites W2087548747 @default.
• W2110406916 cites W2087592242 @default.
• W2110406916 cites W2087609924 @default.
• W2110406916 cites W2089747862 @default.
• W2110406916 cites W2089821560 @default.
• W2110406916 cites W2091998173 @default.
• W2110406916 cites W2096988407 @default.
• W2110406916 cites W2102397694 @default.
• W2110406916 cites W2130529018 @default.
• W2110406916 cites W2137339420 @default.
• W2110406916 cites W2154066388 @default.
• W2110406916 cites W2161456562 @default.
• W2110406916 cites W2170645579 @default.
• W2110406916 cites W3190496831 @default.
• W2110406916 cites W8539175 @default.
• W2110406916 doi "https://doi.org/10.1096/fj.10-157628" @default.
• W2110406916 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20643907" @default.
• W2110406916 hasPublicationYear "2010" @default.
• W2110406916 type Work @default.
• W2110406916 sameAs 2110406916 @default.
• W2110406916 citedByCount "34" @default.
• W2110406916 countsByYear W21104069162012 @default.
• W2110406916 countsByYear W21104069162013 @default.
• W2110406916 countsByYear W21104069162014 @default.
• W2110406916 countsByYear W21104069162015 @default.
• W2110406916 countsByYear W21104069162017 @default.
• W2110406916 countsByYear W21104069162018 @default.
• W2110406916 countsByYear W21104069162019 @default.
• W2110406916 countsByYear W21104069162020 @default.
• W2110406916 countsByYear W21104069162021 @default.
• W2110406916 countsByYear W21104069162022 @default.
• W2110406916 countsByYear W21104069162023 @default.
• W2110406916 crossrefType "journal-article" @default.
• W2110406916 hasAuthorship W2110406916A5028253550 @default.
• W2110406916 hasAuthorship W2110406916A5041122525 @default.
• W2110406916 hasAuthorship W2110406916A5053499233 @default.
• W2110406916 hasAuthorship W2110406916A5076658467 @default.
• W2110406916 hasAuthorship W2110406916A5089510225 @default.
• W2110406916 hasConcept C141071460 @default.
• W2110406916 hasConcept C169760540 @default.
• W2110406916 hasConcept C171056886 @default.
• W2110406916 hasConcept C189165786 @default.
• W2110406916 hasConcept C2777594495 @default.
• W2110406916 hasConcept C2778334475 @default.
• W2110406916 hasConcept C2779632786 @default.
• W2110406916 hasConcept C2779814568 @default.
• W2110406916 hasConcept C2780775167 @default.
• W2110406916 hasConcept C71924100 @default.
• W2110406916 hasConcept C86803240 @default.
• W2110406916 hasConcept C95444343 @default.
• W2110406916 hasConceptScore W2110406916C141071460 @default.
• W2110406916 hasConceptScore W2110406916C169760540 @default.
• W2110406916 hasConceptScore W2110406916C171056886 @default.
• W2110406916 hasConceptScore W2110406916C189165786 @default.
• W2110406916 hasConceptScore W2110406916C2777594495 @default.
• W2110406916 hasConceptScore W2110406916C2778334475 @default.
• W2110406916 hasConceptScore W2110406916C2779632786 @default.
• W2110406916 hasConceptScore W2110406916C2779814568 @default.
• W2110406916 hasConceptScore W2110406916C2780775167 @default.
• W2110406916 hasConceptScore W2110406916C71924100 @default.
• W2110406916 hasConceptScore W2110406916C86803240 @default.

• next