FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110408075> ?p ?o ?g. }

• W2110408075 abstract "Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is an unexplained incapacitating illness that may affect up to 4 million people in the United States alone. There are no validated laboratory tests for diagnosis or management despite global efforts to find biomarkers of disease. We considered the possibility that inability to identify such biomarkers reflected variations in diagnostic criteria and laboratory methods as well as the timing of sample collection during the course of the illness. Accordingly, we leveraged two large, multicenter cohort studies of ME/CFS to assess the relationship of immune signatures with diagnosis, illness duration, and other clinical variables. Controls were frequency-matched on key variables known to affect immune status, including season of sampling and geographic site, in addition to age and sex. We report here distinct alterations in plasma immune signatures early in the course of ME/CFS (n = 52) relative to healthy controls (n = 348) that are not present in subjects with longer duration of illness (n = 246). Analyses based on disease duration revealed that early ME/CFS cases had a prominent activation of both pro- and anti-inflammatory cytokines as well as dissociation of intercytokine regulatory networks. We found a stronger correlation of cytokine alterations with illness duration than with measures of illness severity, suggesting that the immunopathology of ME/CFS is not static. These findings have critical implications for discovery of interventional strategies and early diagnosis of ME/CFS." @default.
• W2110408075 created "2016-06-24" @default.
• W2110408075 creator A5002506184 @default.
• W2110408075 creator A5009074771 @default.
• W2110408075 creator A5011861328 @default.
• W2110408075 creator A5041137562 @default.
• W2110408075 creator A5042626323 @default.
• W2110408075 creator A5058548310 @default.
• W2110408075 creator A5064089801 @default.
• W2110408075 creator A5064445273 @default.
• W2110408075 creator A5068801478 @default.
• W2110408075 creator A5081213309 @default.
• W2110408075 creator A5082013064 @default.
• W2110408075 creator A5082183964 @default.
• W2110408075 creator A5090343848 @default.
• W2110408075 date "2015-02-06" @default.
• W2110408075 modified "2023-10-18" @default.
• W2110408075 title "Distinct plasma immune signatures in ME/CFS are present early in the course of illness" @default.
• W2110408075 cites W105054839 @default.
• W2110408075 cites W1489805892 @default.
• W2110408075 cites W1514528460 @default.
• W2110408075 cites W1530235393 @default.
• W2110408075 cites W1533461809 @default.
• W2110408075 cites W1542786120 @default.
• W2110408075 cites W1971350188 @default.
• W2110408075 cites W1980454503 @default.
• W2110408075 cites W1981982266 @default.
• W2110408075 cites W1985008482 @default.
• W2110408075 cites W1987094938 @default.
• W2110408075 cites W1989457118 @default.
• W2110408075 cites W1990552018 @default.
• W2110408075 cites W1995523953 @default.
• W2110408075 cites W1997379610 @default.
• W2110408075 cites W2003239266 @default.
• W2110408075 cites W2004105684 @default.
• W2110408075 cites W2008087869 @default.
• W2110408075 cites W2017275115 @default.
• W2110408075 cites W2024406316 @default.
• W2110408075 cites W2033811826 @default.
• W2110408075 cites W2034103466 @default.
• W2110408075 cites W2037484801 @default.
• W2110408075 cites W2041818093 @default.
• W2110408075 cites W2043416239 @default.
• W2110408075 cites W2045470312 @default.
• W2110408075 cites W2052726153 @default.
• W2110408075 cites W2056763517 @default.
• W2110408075 cites W2057002646 @default.
• W2110408075 cites W2057451858 @default.
• W2110408075 cites W2058705093 @default.
• W2110408075 cites W2064021071 @default.
• W2110408075 cites W2073034575 @default.
• W2110408075 cites W2076268623 @default.
• W2110408075 cites W2082225452 @default.
• W2110408075 cites W2090023607 @default.
• W2110408075 cites W2092396833 @default.
• W2110408075 cites W2094513896 @default.
• W2110408075 cites W2094628147 @default.
• W2110408075 cites W2096779842 @default.
• W2110408075 cites W2098287790 @default.
• W2110408075 cites W2103005937 @default.
• W2110408075 cites W2104169421 @default.
• W2110408075 cites W2107697308 @default.
• W2110408075 cites W2110918135 @default.
• W2110408075 cites W2115959705 @default.
• W2110408075 cites W2116310706 @default.
• W2110408075 cites W2118518863 @default.
• W2110408075 cites W2126610705 @default.
• W2110408075 cites W2126964152 @default.
• W2110408075 cites W2130459043 @default.
• W2110408075 cites W2144852086 @default.
• W2110408075 cites W2145217447 @default.
• W2110408075 cites W2149058641 @default.
• W2110408075 cites W2149788894 @default.
• W2110408075 cites W2151712474 @default.
• W2110408075 cites W2154393148 @default.
• W2110408075 cites W2154899592 @default.
• W2110408075 cites W2156166354 @default.
• W2110408075 cites W2157345046 @default.
• W2110408075 cites W2160437360 @default.
• W2110408075 cites W2166567716 @default.
• W2110408075 cites W2167012568 @default.
• W2110408075 cites W2326329635 @default.
• W2110408075 cites W2407689217 @default.
• W2110408075 cites W2411507274 @default.
• W2110408075 cites W35374509 @default.
• W2110408075 cites W4211136254 @default.
• W2110408075 doi "https://doi.org/10.1126/sciadv.1400121" @default.
• W2110408075 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4465185" @default.
• W2110408075 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26079000" @default.
• W2110408075 hasPublicationYear "2015" @default.
• W2110408075 type Work @default.
• W2110408075 sameAs 2110408075 @default.
• W2110408075 citedByCount "184" @default.
• W2110408075 countsByYear W21104080752015 @default.
• W2110408075 countsByYear W21104080752016 @default.
• W2110408075 countsByYear W21104080752017 @default.
• W2110408075 countsByYear W21104080752018 @default.
• W2110408075 countsByYear W21104080752019 @default.
• W2110408075 countsByYear W21104080752020 @default.
• W2110408075 countsByYear W21104080752021 @default.

• next