Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110408951> ?p ?o ?g. }
- W2110408951 endingPage "23" @default.
- W2110408951 startingPage "12" @default.
- W2110408951 abstract "The PDGF system, comprising four isoforms (PDGF-A, -B, -C, and -D) and two receptor chains (PDGFR-α and -β), plays important roles in wound healing, atherosclerosis, fibrosis, and malignancy. Components of the system are expressed constitutively or inducibly in most renal cells. They regulate a multitude of pathophysiologic events, ranging from cell proliferation and migration to extracellular matrix accumulation, production of pro- and anti-inflammatory mediators, tissue permeability, and regulation of hemodynamics. Genetic deletion of PDGF-B or PDGFR-β results in an absent glomerular mesangium, whereas PDGF-C and PDGFR-α contribute to the formation of the renal cortical interstitium. Almost all experimental and human renal diseases are characterized by altered expression of components of the PDGF system. Infusion or systemic overexpression of PDGF-B or -D induces prominent mesangioproliferative changes and renal fibrosis. Intervention studies identified PDGF-C as a mediator of renal interstitial fibrosis and PDGF-B and -D as key factors involved in mesangioproliferative disease and renal interstitial fibrosis. These data establish PDGF as one of the best characterized growth factors in renal disease and the most potent stimulus of mesangial cell proliferation currently identified. Accordingly, targeted intervention against the various PDGF isoforms offers a promising novel therapeutic approach to renal disease." @default.
- W2110408951 created "2016-06-24" @default.
- W2110408951 creator A5001027249 @default.
- W2110408951 creator A5002246212 @default.
- W2110408951 creator A5022177889 @default.
- W2110408951 date "2008-01-01" @default.
- W2110408951 modified "2023-10-16" @default.
- W2110408951 title "A New Look at Platelet-Derived Growth Factor in Renal Disease" @default.
- W2110408951 cites W1483090589 @default.
- W2110408951 cites W1556322054 @default.
- W2110408951 cites W1587419561 @default.
- W2110408951 cites W1920412901 @default.
- W2110408951 cites W1964435874 @default.
- W2110408951 cites W1966792873 @default.
- W2110408951 cites W1967992497 @default.
- W2110408951 cites W1968036401 @default.
- W2110408951 cites W1970709922 @default.
- W2110408951 cites W1973552578 @default.
- W2110408951 cites W1974659616 @default.
- W2110408951 cites W1977212183 @default.
- W2110408951 cites W1977303408 @default.
- W2110408951 cites W1977935672 @default.
- W2110408951 cites W1978166197 @default.
- W2110408951 cites W1979944308 @default.
- W2110408951 cites W1980389683 @default.
- W2110408951 cites W1981310451 @default.
- W2110408951 cites W1984748294 @default.
- W2110408951 cites W1984797080 @default.
- W2110408951 cites W1986499750 @default.
- W2110408951 cites W1987514640 @default.
- W2110408951 cites W1988760910 @default.
- W2110408951 cites W1991577267 @default.
- W2110408951 cites W1993754752 @default.
- W2110408951 cites W1994778563 @default.
- W2110408951 cites W1996385798 @default.
- W2110408951 cites W1997080687 @default.
- W2110408951 cites W1997998499 @default.
- W2110408951 cites W1998990808 @default.
- W2110408951 cites W1999355179 @default.
- W2110408951 cites W2000288269 @default.
- W2110408951 cites W2000519471 @default.
- W2110408951 cites W2003135236 @default.
- W2110408951 cites W2003762248 @default.
- W2110408951 cites W2007463241 @default.
- W2110408951 cites W2008091740 @default.
- W2110408951 cites W2010203793 @default.
- W2110408951 cites W2012460154 @default.
- W2110408951 cites W2012498955 @default.
- W2110408951 cites W2012900183 @default.
- W2110408951 cites W2012989068 @default.
- W2110408951 cites W2013920567 @default.
- W2110408951 cites W2015338496 @default.
- W2110408951 cites W2016703850 @default.
- W2110408951 cites W2016718666 @default.
- W2110408951 cites W2017777890 @default.
- W2110408951 cites W2018086730 @default.
- W2110408951 cites W2019358676 @default.
- W2110408951 cites W2019829774 @default.
- W2110408951 cites W2019906442 @default.
- W2110408951 cites W2021860185 @default.
- W2110408951 cites W2024459956 @default.
- W2110408951 cites W2025654776 @default.
- W2110408951 cites W2025871490 @default.
- W2110408951 cites W2032024763 @default.
- W2110408951 cites W2032172246 @default.
- W2110408951 cites W2032341330 @default.
- W2110408951 cites W2032954920 @default.
- W2110408951 cites W2033941047 @default.
- W2110408951 cites W2034186781 @default.
- W2110408951 cites W2035599975 @default.
- W2110408951 cites W2040137623 @default.
- W2110408951 cites W2043657079 @default.
- W2110408951 cites W2043899032 @default.
- W2110408951 cites W2045440936 @default.
- W2110408951 cites W2047881817 @default.
- W2110408951 cites W2048193940 @default.
- W2110408951 cites W2051433485 @default.
- W2110408951 cites W2054130194 @default.
- W2110408951 cites W2058387598 @default.
- W2110408951 cites W2058786654 @default.
- W2110408951 cites W2059051865 @default.
- W2110408951 cites W2060197438 @default.
- W2110408951 cites W2062018389 @default.
- W2110408951 cites W2063899161 @default.
- W2110408951 cites W2067737155 @default.
- W2110408951 cites W2071217846 @default.
- W2110408951 cites W2072663590 @default.
- W2110408951 cites W2073273509 @default.
- W2110408951 cites W2078349330 @default.
- W2110408951 cites W2078663145 @default.
- W2110408951 cites W2080669098 @default.
- W2110408951 cites W2083398588 @default.
- W2110408951 cites W2085295620 @default.
- W2110408951 cites W2086331541 @default.
- W2110408951 cites W2087457069 @default.
- W2110408951 cites W2088056587 @default.
- W2110408951 cites W2090283739 @default.
- W2110408951 cites W2091918469 @default.