FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110409819> ?p ?o ?g. }

• W2110409819 endingPage "e22489" @default.
• W2110409819 startingPage "e22489" @default.
• W2110409819 abstract "Point mutations in LRRK2 cause autosomal dominant Parkinson's disease. Despite extensive efforts to determine the mechanism of cell death in patients with LRRK2 mutations, the aetiology of LRRK2 PD is not well understood. To examine possible alterations in gene expression linked to the presence of LRRK2 mutations, we carried out a case versus control analysis of global gene expression in three systems: fibroblasts isolated from LRRK2 mutation carriers and healthy, non-mutation carrying controls; brain tissue from G2019S mutation carriers and controls; and HEK293 inducible LRRK2 wild type and mutant cell lines. No significant alteration in gene expression was found in these systems following correction for multiple testing. These data suggest that any alterations in basal gene expression in fibroblasts or cell lines containing mutations in LRRK2 are likely to be quantitatively small. This work suggests that LRRK2 is unlikely to play a direct role in modulation of gene expression, although it remains possible that this protein can influence mRNA expression under pathogenic cicumstances." @default.
• W2110409819 created "2016-06-24" @default.
• W2110409819 creator A5000831279 @default.
• W2110409819 creator A5005572028 @default.
• W2110409819 creator A5020514779 @default.
• W2110409819 creator A5031799662 @default.
• W2110409819 creator A5040011139 @default.
• W2110409819 creator A5040914154 @default.
• W2110409819 creator A5042439287 @default.
• W2110409819 creator A5044516423 @default.
• W2110409819 creator A5048287126 @default.
• W2110409819 creator A5049640833 @default.
• W2110409819 creator A5059770430 @default.
• W2110409819 creator A5064191051 @default.
• W2110409819 creator A5067662737 @default.
• W2110409819 creator A5068671730 @default.
• W2110409819 creator A5071579004 @default.
• W2110409819 creator A5072443513 @default.
• W2110409819 creator A5077359733 @default.
• W2110409819 creator A5079926109 @default.
• W2110409819 creator A5082066769 @default.
• W2110409819 creator A5082164081 @default.
• W2110409819 creator A5085868374 @default.
• W2110409819 date "2011-07-22" @default.
• W2110409819 modified "2023-10-09" @default.
• W2110409819 title "Pathogenic LRRK2 Mutations Do Not Alter Gene Expression in Cell Model Systems or Human Brain Tissue" @default.
• W2110409819 cites W1189738588 @default.
• W2110409819 cites W1696199194 @default.
• W2110409819 cites W1973002254 @default.
• W2110409819 cites W1977990240 @default.
• W2110409819 cites W1981111142 @default.
• W2110409819 cites W1990045885 @default.
• W2110409819 cites W1992365739 @default.
• W2110409819 cites W2003126320 @default.
• W2110409819 cites W2031884668 @default.
• W2110409819 cites W2034027186 @default.
• W2110409819 cites W2047565527 @default.
• W2110409819 cites W2053066346 @default.
• W2110409819 cites W2055619740 @default.
• W2110409819 cites W2073954164 @default.
• W2110409819 cites W2085211004 @default.
• W2110409819 cites W2099677820 @default.
• W2110409819 cites W2100300726 @default.
• W2110409819 cites W2124681346 @default.
• W2110409819 cites W2133968430 @default.
• W2110409819 cites W2148641246 @default.
• W2110409819 doi "https://doi.org/10.1371/journal.pone.0022489" @default.
• W2110409819 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3269322" @default.
• W2110409819 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21799870" @default.
• W2110409819 hasPublicationYear "2011" @default.
• W2110409819 type Work @default.
• W2110409819 sameAs 2110409819 @default.
• W2110409819 citedByCount "27" @default.
• W2110409819 countsByYear W21104098192012 @default.
• W2110409819 countsByYear W21104098192013 @default.
• W2110409819 countsByYear W21104098192014 @default.
• W2110409819 countsByYear W21104098192015 @default.
• W2110409819 countsByYear W21104098192016 @default.
• W2110409819 countsByYear W21104098192017 @default.
• W2110409819 countsByYear W21104098192018 @default.
• W2110409819 countsByYear W21104098192019 @default.
• W2110409819 countsByYear W21104098192020 @default.
• W2110409819 crossrefType "journal-article" @default.
• W2110409819 hasAuthorship W2110409819A5000831279 @default.
• W2110409819 hasAuthorship W2110409819A5005572028 @default.
• W2110409819 hasAuthorship W2110409819A5020514779 @default.
• W2110409819 hasAuthorship W2110409819A5031799662 @default.
• W2110409819 hasAuthorship W2110409819A5040011139 @default.
• W2110409819 hasAuthorship W2110409819A5040914154 @default.
• W2110409819 hasAuthorship W2110409819A5042439287 @default.
• W2110409819 hasAuthorship W2110409819A5044516423 @default.
• W2110409819 hasAuthorship W2110409819A5048287126 @default.
• W2110409819 hasAuthorship W2110409819A5049640833 @default.
• W2110409819 hasAuthorship W2110409819A5059770430 @default.
• W2110409819 hasAuthorship W2110409819A5064191051 @default.
• W2110409819 hasAuthorship W2110409819A5067662737 @default.
• W2110409819 hasAuthorship W2110409819A5068671730 @default.
• W2110409819 hasAuthorship W2110409819A5071579004 @default.
• W2110409819 hasAuthorship W2110409819A5072443513 @default.
• W2110409819 hasAuthorship W2110409819A5077359733 @default.
• W2110409819 hasAuthorship W2110409819A5079926109 @default.
• W2110409819 hasAuthorship W2110409819A5082066769 @default.
• W2110409819 hasAuthorship W2110409819A5082164081 @default.
• W2110409819 hasAuthorship W2110409819A5085868374 @default.
• W2110409819 hasBestOaLocation W21104098191 @default.
• W2110409819 hasConcept C104317684 @default.
• W2110409819 hasConcept C143065580 @default.
• W2110409819 hasConcept C150194340 @default.
• W2110409819 hasConcept C153911025 @default.
• W2110409819 hasConcept C165864922 @default.
• W2110409819 hasConcept C174510640 @default.
• W2110409819 hasConcept C176944494 @default.
• W2110409819 hasConcept C2780427247 @default.
• W2110409819 hasConcept C2994225774 @default.
• W2110409819 hasConcept C501734568 @default.
• W2110409819 hasConcept C54355233 @default.
• W2110409819 hasConcept C86803240 @default.
• W2110409819 hasConceptScore W2110409819C104317684 @default.

• next