FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110419304> ?p ?o ?g. }

• W2110419304 endingPage "302" @default.
• W2110419304 startingPage "296" @default.
• W2110419304 abstract "Antibodies to hepatitis B core antigen (anti-HBc) and e antigen (anti-HBe) were assayed in 46 sera from ten patients with acute hepatitis B utilizing immunoglobulin class- and subclass-specific enzyme immunoassays (EIAs). The sera were sampled 1 to 512 days after onset of hepatic symptoms. Four patients cleared HBsAg rapidly, within 24 days, and six patients cleared HBsAg slowly, within 27–74 days after the onset of symptoms. In three of the patients with rapid clearance of HBsAg, hepatitis B virus (HBV) DNA was not detected in sera tested during the first week after onset. The fourth patient was not tested until 12 days after onset and was then found to be negative for HBV DNA. In four of the patients with slow clearance of HBsAg, HBV DNA was present during the first week of illness. In the other two patients, HBV DNA was not detected in the first serum, 11 and 17 days after the onset of illness. Anti-HBc IgM and IgA1 were detected in all patients, with maximum titers shortly after onset. Anti-HBc IgG1 was present in all sera tested. Anti-HBc IgG2 was not detected in any of the sera. Anti-HBc IgG3 and IgG4 were detected in all patient sera, with IgG3 paralleling IgG1, and IgG4 mainly in sera long after onset. Anti-HBe IgG1, IgG3, and IgG4 were detected in three, two, and two patients, respectively. Anti-HBe IgG2, IgM, IgA1, or IgA2 was not found in any patient. The time required for maximum titer of anti-HBc IgG1 was shorter in the patients with rapid clearance of HBsAg. Thus, in these patients, the geometric mean titer (GMT) of anti-HBc IgG1 had not increased significantly, in sera sampled 56–182 days after onset, whereas, in the patients with slow clearance of HBsAg, the increase in GMT of anti-HBc IgG1 was significant (P < 0.05; Student's t test). The humoral responses to HBcAg and HBeAg in acute hepatitis B differ in that HBcAg elicits a vigorous IgM or IgA1 response whereas HBeAg elicits only low levels of IgG, mainly IgG1. Thus our findings support differences regarding T-cell dependence, when comparing the humoral responses to HBcAg and HBeAg." @default.
• W2110419304 created "2016-06-24" @default.
• W2110419304 creator A5009731421 @default.
• W2110419304 creator A5026654277 @default.
• W2110419304 creator A5059343991 @default.
• W2110419304 creator A5075939124 @default.
• W2110419304 date "1989-12-01" @default.
• W2110419304 modified "2023-10-17" @default.
• W2110419304 title "Immunoglobulin isotypes of anti-HBc and anti-HBe and hepatitis B virus (HBV) DNA elimination in acute hepatitis B" @default.
• W2110419304 cites W1605300572 @default.
• W2110419304 cites W1869339365 @default.
• W2110419304 cites W1958307240 @default.
• W2110419304 cites W1972942325 @default.
• W2110419304 cites W1974659403 @default.
• W2110419304 cites W1980095345 @default.
• W2110419304 cites W1991207509 @default.
• W2110419304 cites W1997462663 @default.
• W2110419304 cites W2006594750 @default.
• W2110419304 cites W2026520755 @default.
• W2110419304 cites W2033822244 @default.
• W2110419304 cites W2036463478 @default.
• W2110419304 cites W2048024207 @default.
• W2110419304 cites W2078819144 @default.
• W2110419304 cites W2089839878 @default.
• W2110419304 cites W2095569904 @default.
• W2110419304 cites W2102538669 @default.
• W2110419304 cites W2113597524 @default.
• W2110419304 cites W2123501241 @default.
• W2110419304 cites W2144278109 @default.
• W2110419304 cites W2157356740 @default.
• W2110419304 cites W2166954066 @default.
• W2110419304 cites W2171426960 @default.
• W2110419304 cites W2334749992 @default.
• W2110419304 cites W2012135042 @default.
• W2110419304 doi "https://doi.org/10.1002/jmv.1890290414" @default.
• W2110419304 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2621456" @default.
• W2110419304 hasPublicationYear "1989" @default.
• W2110419304 type Work @default.
• W2110419304 sameAs 2110419304 @default.
• W2110419304 citedByCount "13" @default.
• W2110419304 crossrefType "journal-article" @default.
• W2110419304 hasAuthorship W2110419304A5009731421 @default.
• W2110419304 hasAuthorship W2110419304A5026654277 @default.
• W2110419304 hasAuthorship W2110419304A5059343991 @default.
• W2110419304 hasAuthorship W2110419304A5075939124 @default.
• W2110419304 hasConcept C126894567 @default.
• W2110419304 hasConcept C138944611 @default.
• W2110419304 hasConcept C147483822 @default.
• W2110419304 hasConcept C159047783 @default.
• W2110419304 hasConcept C159654299 @default.
• W2110419304 hasConcept C203014093 @default.
• W2110419304 hasConcept C2522874641 @default.
• W2110419304 hasConcept C2776029263 @default.
• W2110419304 hasConcept C2776194381 @default.
• W2110419304 hasConcept C2777382497 @default.
• W2110419304 hasConcept C2777410769 @default.
• W2110419304 hasConcept C2780593183 @default.
• W2110419304 hasConcept C2780617729 @default.
• W2110419304 hasConcept C2908737250 @default.
• W2110419304 hasConcept C32611913 @default.
• W2110419304 hasConcept C71924100 @default.
• W2110419304 hasConceptScore W2110419304C126894567 @default.
• W2110419304 hasConceptScore W2110419304C138944611 @default.
• W2110419304 hasConceptScore W2110419304C147483822 @default.
• W2110419304 hasConceptScore W2110419304C159047783 @default.
• W2110419304 hasConceptScore W2110419304C159654299 @default.
• W2110419304 hasConceptScore W2110419304C203014093 @default.
• W2110419304 hasConceptScore W2110419304C2522874641 @default.
• W2110419304 hasConceptScore W2110419304C2776029263 @default.
• W2110419304 hasConceptScore W2110419304C2776194381 @default.
• W2110419304 hasConceptScore W2110419304C2777382497 @default.
• W2110419304 hasConceptScore W2110419304C2777410769 @default.
• W2110419304 hasConceptScore W2110419304C2780593183 @default.
• W2110419304 hasConceptScore W2110419304C2780617729 @default.
• W2110419304 hasConceptScore W2110419304C2908737250 @default.
• W2110419304 hasConceptScore W2110419304C32611913 @default.
• W2110419304 hasConceptScore W2110419304C71924100 @default.
• W2110419304 hasIssue "4" @default.
• W2110419304 hasLocation W21104193041 @default.
• W2110419304 hasLocation W21104193042 @default.
• W2110419304 hasOpenAccess W2110419304 @default.
• W2110419304 hasPrimaryLocation W21104193041 @default.
• W2110419304 hasRelatedWork W1494523999 @default.
• W2110419304 hasRelatedWork W1967348014 @default.
• W2110419304 hasRelatedWork W1979784258 @default.
• W2110419304 hasRelatedWork W2006079246 @default.
• W2110419304 hasRelatedWork W2098654902 @default.
• W2110419304 hasRelatedWork W2126348795 @default.
• W2110419304 hasRelatedWork W2191973668 @default.
• W2110419304 hasRelatedWork W2225909803 @default.
• W2110419304 hasRelatedWork W2328038080 @default.
• W2110419304 hasRelatedWork W2373048719 @default.
• W2110419304 hasVolume "29" @default.
• W2110419304 isParatext "false" @default.
• W2110419304 isRetracted "false" @default.
• W2110419304 magId "2110419304" @default.
• W2110419304 workType "article" @default.