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• W2110429413 abstract "PurposeExperimental evidence suggests that lactate is neuroprotective after acute brain injury; however, data in humans are lacking. We examined whether exogenous lactate supplementation improves cerebral energy metabolism in humans with traumatic brain injury (TBI).MethodsWe prospectively studied 15 consecutive patients with severe TBI monitored with cerebral microdialysis (CMD), brain tissue PO2 (PbtO2), and intracranial pressure (ICP). Intervention consisted of a 3-h intravenous infusion of hypertonic sodium lactate (aiming to increase systemic lactate to ca. 5 mmol/L), administered in the early phase following TBI. We examined the effect of sodium lactate on neurochemistry (CMD lactate, pyruvate, glucose, and glutamate), PbtO2, and ICP.ResultsTreatment was started on average 33 ± 16 h after TBI. A mixed-effects multilevel regression model revealed that sodium lactate therapy was associated with a significant increase in CMD concentrations of lactate [coefficient 0.47 mmol/L, 95 % confidence interval (CI) 0.31–0.63 mmol/L], pyruvate [13.1 (8.78–17.4) μmol/L], and glucose [0.1 (0.04–0.16) mmol/L; all p < 0.01]. A concomitant reduction of CMD glutamate [−0.95 (−1.94 to 0.06) mmol/L, p = 0.06] and ICP [−0.86 (−1.47 to −0.24) mmHg, p < 0.01] was also observed.ConclusionsExogenous supplemental lactate can be utilized aerobically as a preferential energy substrate by the injured human brain, with sparing of cerebral glucose. Increased availability of cerebral extracellular pyruvate and glucose, coupled with a reduction of brain glutamate and ICP, suggests that hypertonic lactate therapy has beneficial cerebral metabolic and hemodynamic effects after TBI." @default.
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• W2110429413 date "2014-01-30" @default.
• W2110429413 modified "2023-09-30" @default.
• W2110429413 title "Cerebral metabolic effects of exogenous lactate supplementation on the injured human brain" @default.
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• W2110429413 doi "https://doi.org/10.1007/s00134-013-3203-6" @default.
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