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• W2110432051 endingPage "5537" @default.
• W2110432051 startingPage "5533" @default.
• W2110432051 abstract "MicroRNA-10b (miR-10b) has been reported to play an important role in some types of cancer, but the effects and possible mechanisms of action of miR-10b in the metastasis of nasopharyngeal carcinoma cells (NPC) have not been explored. The aim of the present study was to investigate the function of miR-10b in nasopharyngeal carcinoma and to determine the molecular mechanisms underlying its action. The MTT assay was used to assess proliferation of CNE-2Z cells. Wound healing and transwell migration assays were applied to assess cell migration and invasion, while and expression of E-cadherin and MMP-9 were detected using Western blot analysis. Real-time PCR was employed to detect the expression of genes related to migration and invasion and the 2-??Ct method was used to calculate the degree of expression. MTT assay showed the expression of miR-10b to have no effect on the proliferation of NPC cell lines. The wound healing assay showed that miR-10b mimics promoted the mobility and invasion of NPC cell lines. Inhibitors of miR-10b reduced the ability of NPC cell lines to migrate and invade. In addition, the expression of genes related to migration and invasion, such as E-cadherin, vimentin, and MMP-9, were confirmed to be different in the CNE-2Z NPC cell line transfected with miR-10b mimics and with miR-10b inhibitors. In the present study, miR-10b was found to upregulate the expression of MMP-9 and knockdown of miR-10b was found to significantly downregulate the expression of E-cadherin. On the whole, these results showed that miR-10b plays an important role in the invasion and metastasis of NPC cells." @default.
• W2110432051 created "2016-06-24" @default.
• W2110432051 creator A5023305873 @default.
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• W2110432051 date "2013-09-30" @default.
• W2110432051 modified "2023-09-28" @default.
• W2110432051 title "miR-10b Promotes Migration and Invasion in Nasopharyngeal Carcinoma Cells" @default.
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• W2110432051 doi "https://doi.org/10.7314/apjcp.2013.14.9.5533" @default.
• W2110432051 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24175854" @default.
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