FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110434557> ?p ?o ?g. }

• W2110434557 endingPage "762" @default.
• W2110434557 startingPage "754" @default.
• W2110434557 abstract "Pathogenic mechanisms responsible for the undulating symptom pattern, or indeed causative agents for the development, of inflammatory bowel diseases [IBD] are largely unknown. Many physicians and most patients are convinced that stress affects the course of IBD. As with most factors that contribute to IBD, it is unclear whether stress merely exacerbates established disease or indeed contributes to the development of disease. We designed this study to investigate whether stress induces or aggravates colitis in interkeukin-10 knockout [IL-10 ko] mice and to determine the role of intestinal permeability in this model of stress-related colitis.The study was divided into two experiments depending on the age of the animals. Stress was induced by placing 5-week old disease-free mice or 8-week-old mice (IL-10ko and wild type [wt]) with mild colitis in movement restrainers for 2h twice daily for 7 days. The development of colitis was assessed clinically [weight and faecal pellet production], histologically [haematoxylin and eosin staining], and biochemically [colonic IL-2, IL-4, IL-6, IL-12p40, TNFα, and IFNγ]. Permeability was measured in Ussing chambers.Faecal pellet production increased significantly in all stressed animals compared with control animals, indicating successful application of stress. Stressed 8-week old mice lost weight [p < 0.001] and stressed IL-10(-/-) mice showed a significantly increased histological score compared with non-stressed or wt mice [p < 0.001]. There was no appreciable difference in cytokine production. Stress did not alter intestinal permeability.Restraint stress aggravates experimental colitis in 8-week old IL-10ko mice but cannot induce colitis in disease-free younger mice. This is not mediated by an increased intestinal permeability." @default.
• W2110434557 created "2016-06-24" @default.
• W2110434557 creator A5016465497 @default.
• W2110434557 creator A5036969238 @default.
• W2110434557 creator A5039344041 @default.
• W2110434557 creator A5048910870 @default.
• W2110434557 creator A5053636752 @default.
• W2110434557 creator A5083134750 @default.
• W2110434557 creator A5083894026 @default.
• W2110434557 date "2015-06-05" @default.
• W2110434557 modified "2023-09-24" @default.
• W2110434557 title "Aggravation of Established Colitis in Specific Pathogen-free IL-10 Knockout Mice by Restraint Stress Is Not Mediated by Increased Colonic Permeability" @default.
• W2110434557 cites W1543506296 @default.
• W2110434557 cites W1974161819 @default.
• W2110434557 cites W1977647049 @default.
• W2110434557 cites W1983233325 @default.
• W2110434557 cites W1983251816 @default.
• W2110434557 cites W1985240984 @default.
• W2110434557 cites W2001452832 @default.
• W2110434557 cites W2010632578 @default.
• W2110434557 cites W2014385625 @default.
• W2110434557 cites W2018412931 @default.
• W2110434557 cites W2023076162 @default.
• W2110434557 cites W2025065287 @default.
• W2110434557 cites W2027023872 @default.
• W2110434557 cites W2029498867 @default.
• W2110434557 cites W2029739208 @default.
• W2110434557 cites W2035048561 @default.
• W2110434557 cites W2036281919 @default.
• W2110434557 cites W2039841890 @default.
• W2110434557 cites W2042570237 @default.
• W2110434557 cites W2047170682 @default.
• W2110434557 cites W2052584095 @default.
• W2110434557 cites W2057539040 @default.
• W2110434557 cites W2066281651 @default.
• W2110434557 cites W2066850998 @default.
• W2110434557 cites W2077080249 @default.
• W2110434557 cites W2082214913 @default.
• W2110434557 cites W2086953067 @default.
• W2110434557 cites W2091271888 @default.
• W2110434557 cites W2091453856 @default.
• W2110434557 cites W2095345518 @default.
• W2110434557 cites W2103435003 @default.
• W2110434557 cites W2104249477 @default.
• W2110434557 cites W2111199584 @default.
• W2110434557 cites W2111622892 @default.
• W2110434557 cites W2114164427 @default.
• W2110434557 cites W2116132434 @default.
• W2110434557 cites W2120356787 @default.
• W2110434557 cites W2146367607 @default.
• W2110434557 cites W2156744949 @default.
• W2110434557 cites W2159013446 @default.
• W2110434557 cites W2161893601 @default.
• W2110434557 cites W2165115219 @default.
• W2110434557 cites W2165528446 @default.
• W2110434557 cites W2167111376 @default.
• W2110434557 cites W2168128529 @default.
• W2110434557 doi "https://doi.org/10.1093/ecco-jcc/jjv098" @default.
• W2110434557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26048917" @default.
• W2110434557 hasPublicationYear "2015" @default.
• W2110434557 type Work @default.
• W2110434557 sameAs 2110434557 @default.
• W2110434557 citedByCount "9" @default.
• W2110434557 countsByYear W21104345572016 @default.
• W2110434557 countsByYear W21104345572017 @default.
• W2110434557 countsByYear W21104345572018 @default.
• W2110434557 countsByYear W21104345572020 @default.
• W2110434557 countsByYear W21104345572021 @default.
• W2110434557 countsByYear W21104345572022 @default.
• W2110434557 countsByYear W21104345572023 @default.
• W2110434557 crossrefType "journal-article" @default.
• W2110434557 hasAuthorship W2110434557A5016465497 @default.
• W2110434557 hasAuthorship W2110434557A5036969238 @default.
• W2110434557 hasAuthorship W2110434557A5039344041 @default.
• W2110434557 hasAuthorship W2110434557A5048910870 @default.
• W2110434557 hasAuthorship W2110434557A5053636752 @default.
• W2110434557 hasAuthorship W2110434557A5083134750 @default.
• W2110434557 hasAuthorship W2110434557A5083894026 @default.
• W2110434557 hasBestOaLocation W21104345571 @default.
• W2110434557 hasConcept C126322002 @default.
• W2110434557 hasConcept C134018914 @default.
• W2110434557 hasConcept C164027704 @default.
• W2110434557 hasConcept C170493617 @default.
• W2110434557 hasConcept C182704531 @default.
• W2110434557 hasConcept C203014093 @default.
• W2110434557 hasConcept C2775862500 @default.
• W2110434557 hasConcept C2776914184 @default.
• W2110434557 hasConcept C2778260677 @default.
• W2110434557 hasConcept C2778690821 @default.
• W2110434557 hasConcept C2779134260 @default.
• W2110434557 hasConcept C2781071285 @default.
• W2110434557 hasConcept C71924100 @default.
• W2110434557 hasConcept C90924648 @default.
• W2110434557 hasConceptScore W2110434557C126322002 @default.
• W2110434557 hasConceptScore W2110434557C134018914 @default.
• W2110434557 hasConceptScore W2110434557C164027704 @default.
• W2110434557 hasConceptScore W2110434557C170493617 @default.
• W2110434557 hasConceptScore W2110434557C182704531 @default.

• next