Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110442916> ?p ?o ?g. }
- W2110442916 endingPage "2952" @default.
- W2110442916 startingPage "2939" @default.
- W2110442916 abstract "Signaling by activin-like ligands is important for induction and patterning of mesoderm and endoderm. We have used an antibody that specifically recognizes the phosphorylated and activated form of Smad2, an intracellular transducer of activin-like ligands, to examine how this signaling pathway patterns the early mesendoderm. In contrast to the simple expectation that activin-like signaling should be highest on the dorsal side of the gastrula stage embryo, we have found that while Smad2 phosphorylation is highest dorsally before gastrulation, signaling is attenuated dorsally and is highest on the ventral side by mid-gastrulation. Early dorsal initiation of Smad2 phosphorylation results from cooperation between the vegetally localized maternal transcription factor VegT and dorsally localized β-catenin. The subsequent ventral appearance of Smad2 phosphorylation is dependent on VegT, but not on signaling from the dorsal side. Dorsal attenuation of Smad2 phosphorylation during gastrulation is mediated by early dorsal expression of feedback inhibitors of activin-like signals. In addition to regulation of Smad2 phosphorylation by the expression of activin-like ligands and their antagonists, the responsiveness of embryonic cells to activin-like ligands is also temporally regulated. Ectopic Vg1, Xnr1 and derrière all fail to activate Smad2 phosphorylation until after the midblastula transition, and the onset of responsiveness to these ligands is independent of transcription. Furthermore, the timing of cellular responsiveness differs for Xnr1 and derrière, and these distinct temporal patterns of responsiveness can be correlated with their distinctive phenotypic effects. These observations suggest that the timing of endogenous activin-like signaling is a determinant of patterning in the early Xenopus embryo." @default.
- W2110442916 created "2016-06-24" @default.
- W2110442916 creator A5009589018 @default.
- W2110442916 creator A5011464500 @default.
- W2110442916 creator A5020693147 @default.
- W2110442916 date "2001-08-01" @default.
- W2110442916 modified "2023-10-17" @default.
- W2110442916 title "Timing of endogenous activin-like signals and regional specification of the<i>Xenopus</i>embryo" @default.
- W2110442916 cites W1486617321 @default.
- W2110442916 cites W1659265739 @default.
- W2110442916 cites W1680418198 @default.
- W2110442916 cites W1859128757 @default.
- W2110442916 cites W1890787892 @default.
- W2110442916 cites W1927305112 @default.
- W2110442916 cites W1964316050 @default.
- W2110442916 cites W1967897273 @default.
- W2110442916 cites W1971175769 @default.
- W2110442916 cites W1983136032 @default.
- W2110442916 cites W1984288177 @default.
- W2110442916 cites W1989765285 @default.
- W2110442916 cites W1992374635 @default.
- W2110442916 cites W1993154580 @default.
- W2110442916 cites W1995473388 @default.
- W2110442916 cites W1995644262 @default.
- W2110442916 cites W2003069024 @default.
- W2110442916 cites W2010041789 @default.
- W2110442916 cites W2010926184 @default.
- W2110442916 cites W2011687097 @default.
- W2110442916 cites W2014371162 @default.
- W2110442916 cites W2015929447 @default.
- W2110442916 cites W2017816671 @default.
- W2110442916 cites W2018485286 @default.
- W2110442916 cites W2020581747 @default.
- W2110442916 cites W2024050600 @default.
- W2110442916 cites W2025019677 @default.
- W2110442916 cites W2025568503 @default.
- W2110442916 cites W2030114483 @default.
- W2110442916 cites W2032544386 @default.
- W2110442916 cites W2044384686 @default.
- W2110442916 cites W2059115933 @default.
- W2110442916 cites W2067874905 @default.
- W2110442916 cites W2068224181 @default.
- W2110442916 cites W2069598734 @default.
- W2110442916 cites W2069673898 @default.
- W2110442916 cites W2071130833 @default.
- W2110442916 cites W2074773822 @default.
- W2110442916 cites W2078058386 @default.
- W2110442916 cites W2080816640 @default.
- W2110442916 cites W2081939122 @default.
- W2110442916 cites W2082584450 @default.
- W2110442916 cites W2082955515 @default.
- W2110442916 cites W2088217641 @default.
- W2110442916 cites W2089543118 @default.
- W2110442916 cites W2091637225 @default.
- W2110442916 cites W2091821419 @default.
- W2110442916 cites W2092088384 @default.
- W2110442916 cites W2092490061 @default.
- W2110442916 cites W2098385149 @default.
- W2110442916 cites W2102144828 @default.
- W2110442916 cites W2103031848 @default.
- W2110442916 cites W2105884976 @default.
- W2110442916 cites W2107877778 @default.
- W2110442916 cites W2114512872 @default.
- W2110442916 cites W2115686163 @default.
- W2110442916 cites W2120643964 @default.
- W2110442916 cites W2121077448 @default.
- W2110442916 cites W2126042045 @default.
- W2110442916 cites W2131716017 @default.
- W2110442916 cites W2132584224 @default.
- W2110442916 cites W2133802030 @default.
- W2110442916 cites W2136732727 @default.
- W2110442916 cites W2146434687 @default.
- W2110442916 cites W2148282826 @default.
- W2110442916 cites W2152853156 @default.
- W2110442916 cites W2155920443 @default.
- W2110442916 cites W2156212940 @default.
- W2110442916 cites W2169009865 @default.
- W2110442916 cites W2181871091 @default.
- W2110442916 cites W2182752616 @default.
- W2110442916 cites W2183290663 @default.
- W2110442916 cites W2184173249 @default.
- W2110442916 cites W2186646946 @default.
- W2110442916 cites W2187387463 @default.
- W2110442916 cites W2187553747 @default.
- W2110442916 cites W2188836137 @default.
- W2110442916 cites W2277165468 @default.
- W2110442916 cites W2301785409 @default.
- W2110442916 cites W2333851779 @default.
- W2110442916 cites W2412608594 @default.
- W2110442916 cites W2423159520 @default.
- W2110442916 cites W2439819887 @default.
- W2110442916 cites W2883811173 @default.
- W2110442916 cites W4252276101 @default.
- W2110442916 cites W71606653 @default.
- W2110442916 doi "https://doi.org/10.1242/dev.128.15.2939" @default.
- W2110442916 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11532917" @default.
- W2110442916 hasPublicationYear "2001" @default.
- W2110442916 type Work @default.