Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110444080> ?p ?o ?g. }
- W2110444080 endingPage "1059" @default.
- W2110444080 startingPage "1047" @default.
- W2110444080 abstract "To design rational therapies for JAK2-driven hematological malignancies, we functionally dissected the key survival pathways downstream of hyperactive JAK2. In tumors driven by mutant JAK2, Stat1, Stat3, Stat5, and the Pi3k and Mek/Erk pathways were constitutively active, and gene expression profiling of TEL-JAK2 T-ALL cells revealed the upregulation of prosurvival Bcl-2 family genes. Combining the Bcl-2/Bcl-xL inhibitor ABT-737 with JAK2 inhibitors mediated prolonged disease regressions and cures in mice bearing primary human and mouse JAK2 mutant tumors. Moreover, combined targeting of JAK2 and Bcl-2/Bcl-xL was able to circumvent and overcome acquired resistance to single-agent JAK2 inhibitor treatment. Thus, inhibiting the oncogenic JAK2 signaling network at two nodal points, at the initiating stage (JAK2) and the effector stage (Bcl-2/Bcl-xL), is highly effective and provides a clearly superior therapeutic benefit than targeting just one node. Therefore, we have defined a potentially curative treatment for hematological malignancies expressing constitutively active JAK2." @default.
- W2110444080 created "2016-06-24" @default.
- W2110444080 creator A5002479431 @default.
- W2110444080 creator A5005312877 @default.
- W2110444080 creator A5005421467 @default.
- W2110444080 creator A5007424744 @default.
- W2110444080 creator A5010962927 @default.
- W2110444080 creator A5018882849 @default.
- W2110444080 creator A5020166322 @default.
- W2110444080 creator A5020705585 @default.
- W2110444080 creator A5025660159 @default.
- W2110444080 creator A5027828146 @default.
- W2110444080 creator A5029414830 @default.
- W2110444080 creator A5041678586 @default.
- W2110444080 creator A5041978156 @default.
- W2110444080 creator A5043170079 @default.
- W2110444080 creator A5043466606 @default.
- W2110444080 creator A5048744038 @default.
- W2110444080 creator A5052829828 @default.
- W2110444080 creator A5058771300 @default.
- W2110444080 creator A5062732174 @default.
- W2110444080 creator A5069871520 @default.
- W2110444080 creator A5078917865 @default.
- W2110444080 creator A5081189681 @default.
- W2110444080 date "2013-11-01" @default.
- W2110444080 modified "2023-10-06" @default.
- W2110444080 title "Combined Targeting of JAK2 and Bcl-2/Bcl-xL to Cure Mutant JAK2-Driven Malignancies and Overcome Acquired Resistance to JAK2 Inhibitors" @default.
- W2110444080 cites W1966331260 @default.
- W2110444080 cites W1980568348 @default.
- W2110444080 cites W1983337543 @default.
- W2110444080 cites W1987294127 @default.
- W2110444080 cites W1991213319 @default.
- W2110444080 cites W1994568187 @default.
- W2110444080 cites W1994797967 @default.
- W2110444080 cites W1995383909 @default.
- W2110444080 cites W2012114257 @default.
- W2110444080 cites W2017339352 @default.
- W2110444080 cites W2020150996 @default.
- W2110444080 cites W2021904192 @default.
- W2110444080 cites W2022609682 @default.
- W2110444080 cites W2029318743 @default.
- W2110444080 cites W2037896121 @default.
- W2110444080 cites W2045801606 @default.
- W2110444080 cites W2048807709 @default.
- W2110444080 cites W2049145190 @default.
- W2110444080 cites W2051181798 @default.
- W2110444080 cites W2054792541 @default.
- W2110444080 cites W2054817748 @default.
- W2110444080 cites W2057360098 @default.
- W2110444080 cites W2062984099 @default.
- W2110444080 cites W2065336454 @default.
- W2110444080 cites W2068962767 @default.
- W2110444080 cites W2085419794 @default.
- W2110444080 cites W2092157777 @default.
- W2110444080 cites W2104485296 @default.
- W2110444080 cites W2114414564 @default.
- W2110444080 cites W2117026298 @default.
- W2110444080 cites W2123080389 @default.
- W2110444080 cites W2135699328 @default.
- W2110444080 cites W2139630089 @default.
- W2110444080 cites W2145968395 @default.
- W2110444080 cites W2151734278 @default.
- W2110444080 cites W2154564841 @default.
- W2110444080 cites W2156568059 @default.
- W2110444080 cites W2172242534 @default.
- W2110444080 cites W2337577525 @default.
- W2110444080 cites W4230222844 @default.
- W2110444080 cites W4237200993 @default.
- W2110444080 doi "https://doi.org/10.1016/j.celrep.2013.10.038" @default.
- W2110444080 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3898474" @default.
- W2110444080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24268771" @default.
- W2110444080 hasPublicationYear "2013" @default.
- W2110444080 type Work @default.
- W2110444080 sameAs 2110444080 @default.
- W2110444080 citedByCount "114" @default.
- W2110444080 countsByYear W21104440802014 @default.
- W2110444080 countsByYear W21104440802015 @default.
- W2110444080 countsByYear W21104440802016 @default.
- W2110444080 countsByYear W21104440802017 @default.
- W2110444080 countsByYear W21104440802018 @default.
- W2110444080 countsByYear W21104440802019 @default.
- W2110444080 countsByYear W21104440802020 @default.
- W2110444080 countsByYear W21104440802021 @default.
- W2110444080 countsByYear W21104440802022 @default.
- W2110444080 countsByYear W21104440802023 @default.
- W2110444080 crossrefType "journal-article" @default.
- W2110444080 hasAuthorship W2110444080A5002479431 @default.
- W2110444080 hasAuthorship W2110444080A5005312877 @default.
- W2110444080 hasAuthorship W2110444080A5005421467 @default.
- W2110444080 hasAuthorship W2110444080A5007424744 @default.
- W2110444080 hasAuthorship W2110444080A5010962927 @default.
- W2110444080 hasAuthorship W2110444080A5018882849 @default.
- W2110444080 hasAuthorship W2110444080A5020166322 @default.
- W2110444080 hasAuthorship W2110444080A5020705585 @default.
- W2110444080 hasAuthorship W2110444080A5025660159 @default.
- W2110444080 hasAuthorship W2110444080A5027828146 @default.
- W2110444080 hasAuthorship W2110444080A5029414830 @default.
- W2110444080 hasAuthorship W2110444080A5041678586 @default.