Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110444675> ?p ?o ?g. }
- W2110444675 endingPage "625" @default.
- W2110444675 startingPage "607" @default.
- W2110444675 abstract "Evolutionary trends have been examined in 146 HIV-1 forms (2662 copies, 2311 isolates) polymorphic for the TATA box using the DNA sequence→affinity for TBP regression (TBP is the TATA binding protein). As a result, a statistically significant excess of low-affinity TATA box HIV-1 variants corresponding to a low level of both basal and TAT-dependent expression and, consequently, slow replication of HIV-1 have been detected. A detailed analysis revealed that the excess of slowly replicating HIV-1 is associated with the subtype E-associated TATA box core sequence CATAAAA. Principal Component Analysis performed on 2662 HIV-1 TATA box copies in 70 countries revealed the presence of two principal components, PC1 (75.7% of the variance) and PC2 (23.3% of the variance). They indicate that each of these countries is specifically associated with one of the following trends in HIV-1 evolution: neutral drift around the normal TATA box; neutral drift around the slowly replicating TATA box core sequence (phylogenetic inertia); an adaptive increase in the frequency of the slowly replicating form." @default.
- W2110444675 created "2016-06-24" @default.
- W2110444675 creator A5006578987 @default.
- W2110444675 creator A5008259802 @default.
- W2110444675 creator A5025425343 @default.
- W2110444675 creator A5037933008 @default.
- W2110444675 creator A5038764591 @default.
- W2110444675 creator A5045849494 @default.
- W2110444675 date "2010-06-01" @default.
- W2110444675 modified "2023-09-27" @default.
- W2110444675 title "SNPS IN THE HIV-1 TATA BOX AND THE AIDS PANDEMIC" @default.
- W2110444675 cites W1597865451 @default.
- W2110444675 cites W1897005832 @default.
- W2110444675 cites W1966975236 @default.
- W2110444675 cites W1970301294 @default.
- W2110444675 cites W1973381207 @default.
- W2110444675 cites W1974238583 @default.
- W2110444675 cites W1986473194 @default.
- W2110444675 cites W1989468850 @default.
- W2110444675 cites W1991144403 @default.
- W2110444675 cites W1991330646 @default.
- W2110444675 cites W1994203761 @default.
- W2110444675 cites W1999027354 @default.
- W2110444675 cites W1999966058 @default.
- W2110444675 cites W2002899891 @default.
- W2110444675 cites W2006362317 @default.
- W2110444675 cites W2023479104 @default.
- W2110444675 cites W2029353650 @default.
- W2110444675 cites W2031830783 @default.
- W2110444675 cites W2034488184 @default.
- W2110444675 cites W2041880278 @default.
- W2110444675 cites W2044811718 @default.
- W2110444675 cites W2045950998 @default.
- W2110444675 cites W2057927013 @default.
- W2110444675 cites W2064311051 @default.
- W2110444675 cites W2064703363 @default.
- W2110444675 cites W2068170981 @default.
- W2110444675 cites W2073990872 @default.
- W2110444675 cites W2081539383 @default.
- W2110444675 cites W2086679686 @default.
- W2110444675 cites W2088493593 @default.
- W2110444675 cites W2096658573 @default.
- W2110444675 cites W2098601534 @default.
- W2110444675 cites W2114282483 @default.
- W2110444675 cites W2125374553 @default.
- W2110444675 cites W2128969076 @default.
- W2110444675 cites W2140665904 @default.
- W2110444675 cites W2142593273 @default.
- W2110444675 cites W2143849684 @default.
- W2110444675 cites W2151625863 @default.
- W2110444675 cites W2155388660 @default.
- W2110444675 cites W2157115700 @default.
- W2110444675 cites W2164640003 @default.
- W2110444675 cites W2165608108 @default.
- W2110444675 cites W2166464288 @default.
- W2110444675 cites W2496173866 @default.
- W2110444675 cites W4254980429 @default.
- W2110444675 cites W2048978761 @default.
- W2110444675 doi "https://doi.org/10.1142/s0219720010004677" @default.
- W2110444675 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20556865" @default.
- W2110444675 hasPublicationYear "2010" @default.
- W2110444675 type Work @default.
- W2110444675 sameAs 2110444675 @default.
- W2110444675 citedByCount "15" @default.
- W2110444675 countsByYear W21104446752012 @default.
- W2110444675 countsByYear W21104446752015 @default.
- W2110444675 countsByYear W21104446752016 @default.
- W2110444675 countsByYear W21104446752017 @default.
- W2110444675 countsByYear W21104446752018 @default.
- W2110444675 countsByYear W21104446752019 @default.
- W2110444675 crossrefType "journal-article" @default.
- W2110444675 hasAuthorship W2110444675A5006578987 @default.
- W2110444675 hasAuthorship W2110444675A5008259802 @default.
- W2110444675 hasAuthorship W2110444675A5025425343 @default.
- W2110444675 hasAuthorship W2110444675A5037933008 @default.
- W2110444675 hasAuthorship W2110444675A5038764591 @default.
- W2110444675 hasAuthorship W2110444675A5045849494 @default.
- W2110444675 hasConcept C101762097 @default.
- W2110444675 hasConcept C104317684 @default.
- W2110444675 hasConcept C150194340 @default.
- W2110444675 hasConcept C54355233 @default.
- W2110444675 hasConcept C65888428 @default.
- W2110444675 hasConcept C70721500 @default.
- W2110444675 hasConcept C86803240 @default.
- W2110444675 hasConceptScore W2110444675C101762097 @default.
- W2110444675 hasConceptScore W2110444675C104317684 @default.
- W2110444675 hasConceptScore W2110444675C150194340 @default.
- W2110444675 hasConceptScore W2110444675C54355233 @default.
- W2110444675 hasConceptScore W2110444675C65888428 @default.
- W2110444675 hasConceptScore W2110444675C70721500 @default.
- W2110444675 hasConceptScore W2110444675C86803240 @default.
- W2110444675 hasIssue "03" @default.
- W2110444675 hasLocation W21104446751 @default.
- W2110444675 hasLocation W21104446752 @default.
- W2110444675 hasOpenAccess W2110444675 @default.
- W2110444675 hasPrimaryLocation W21104446751 @default.
- W2110444675 hasRelatedWork W1828691184 @default.
- W2110444675 hasRelatedWork W1903732681 @default.