FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110450140> ?p ?o ?g. }

• W2110450140 endingPage "2142" @default.
• W2110450140 startingPage "2136" @default.
• W2110450140 abstract "Aging, or senescence, defined as a decline in physiological function with age, has long been a focus of research interest for evolutionary biologists. How has natural selection failed to remove genetic effects responsible for such reduced fitness among older individuals? Current evolutionary theory explains this phenomenon by showing that, as a result of the risk of death from environmental causes that individuals experience, the force of selection inevitably weakens with age [1Hamilton W.D. The moulding of senescence by natural selection.J. Theor. Biol. 1966; 12: 12-45Crossref PubMed Scopus (1359) Google Scholar, 2Medawar P.B. An Unsolved Problem in Biology. H.K. Lewis, London1952Google Scholar, 3Williams G.C. Pleiotropy, natural selection, and the evolution of senescence.Evolution Int. J. Org. Evolution. 1957; 11: 398-411Crossref Google Scholar]. This in turn means that genetic mutations having detrimental effects that are only felt late in life might persist in a population. Although widely accepted, this theory rests on the assumption that there is genetic variation for aging in natural systems [4Rose M.R. Evolutionary Biology of Aging. Oxford University Press, Oxford1991Google Scholar, 5Curtsinger J.W. Fukui H.H. Khazaeli A.A. Kirscher A. Pletcher S.D. Promislow D.E.L. Tatar M. Genetic variation and aging.Annu. Rev. Genet. 1995; 29: 553-575Crossref PubMed Scopus (97) Google Scholar], or (equivalently), that genotype-by-age interactions (GxA) occur for fitness. To date, empirical support for this assumption has come almost entirely from laboratory studies on invertebrate systems, most notably Drosophila and C. elegans [6Hughes K.A. Reynolds R.M. Evolutionary and mechanistic theories of aging.Annu. Rev. Entomol. 2005; 50: 421-445Crossref PubMed Scopus (220) Google Scholar, 7Wilson R.H. Morgan T.J. Mackay T.F.C. High-resolution mapping of quantitative trait loci affecting increased life span in Drosophila melanogaster.Genetics. 2006; 173: 1455-1463Crossref PubMed Scopus (30) Google Scholar, 8Charlesworth B. Hughes K.A. Age-specific inbreeding depression and components of genetic variance in relation to the evolution of senescence.Proc. Natl. Acad. Sci. USA. 1996; 93: 6140-6145Crossref PubMed Scopus (168) Google Scholar, 9Hughes K.A. Alipaz J.A. Drnevich J.M. Reynolds R.M. A test of evolutionary theories of aging.Proc. Natl. Acad. Sci. USA. 2002; 99: 14286-14291Crossref PubMed Scopus (117) Google Scholar, 10Snoke M.S. Promislow D.E.L. Quantitative genetic tests of recent senescence theory: age-specific mortality and male fertility in Drosophila melanogaster.Heredity. 2003; 91: 546-556Crossref PubMed Scopus (61) Google Scholar], whereas tests of genetic variation for aging are largely lacking from natural populations [5Curtsinger J.W. Fukui H.H. Khazaeli A.A. Kirscher A. Pletcher S.D. Promislow D.E.L. Tatar M. Genetic variation and aging.Annu. Rev. Genet. 1995; 29: 553-575Crossref PubMed Scopus (97) Google Scholar]. By using data from two wild mammal populations, we perform quantitative genetic analyses of fitness and provide the first evidence for a genetic basis of senescence to come from a study in the natural environment. We find evidence that genetic differences among individuals cause variation in their rates of aging and that additive genetic variance for fitness increases with age, as predicted by the evolutionary theory of senescence." @default.
• W2110450140 created "2016-06-24" @default.
• W2110450140 creator A5022575665 @default.
• W2110450140 creator A5024127282 @default.
• W2110450140 creator A5034616536 @default.
• W2110450140 creator A5036106086 @default.
• W2110450140 creator A5041690593 @default.
• W2110450140 creator A5042121734 @default.
• W2110450140 creator A5063752272 @default.
• W2110450140 creator A5076055146 @default.
• W2110450140 date "2007-12-01" @default.
• W2110450140 modified "2023-10-17" @default.
• W2110450140 title "Evidence for a Genetic Basis of Aging in Two Wild Vertebrate Populations" @default.
• W2110450140 cites W1940291897 @default.
• W2110450140 cites W1966038228 @default.
• W2110450140 cites W1968372425 @default.
• W2110450140 cites W1969746417 @default.
• W2110450140 cites W1974206199 @default.
• W2110450140 cites W1982411080 @default.
• W2110450140 cites W1983638272 @default.
• W2110450140 cites W1986417764 @default.
• W2110450140 cites W2002110270 @default.
• W2110450140 cites W2002356431 @default.
• W2110450140 cites W2003649919 @default.
• W2110450140 cites W2026189243 @default.
• W2110450140 cites W2036516886 @default.
• W2110450140 cites W2047146652 @default.
• W2110450140 cites W2068151054 @default.
• W2110450140 cites W2070487135 @default.
• W2110450140 cites W2073035337 @default.
• W2110450140 cites W2074989255 @default.
• W2110450140 cites W2082920736 @default.
• W2110450140 cites W2091137185 @default.
• W2110450140 cites W2093588915 @default.
• W2110450140 cites W2099459443 @default.
• W2110450140 cites W2099627867 @default.
• W2110450140 cites W2104611083 @default.
• W2110450140 cites W2105123413 @default.
• W2110450140 cites W2113895288 @default.
• W2110450140 cites W2125428236 @default.
• W2110450140 cites W2131649050 @default.
• W2110450140 cites W2138037637 @default.
• W2110450140 cites W2157284046 @default.
• W2110450140 cites W2161300703 @default.
• W2110450140 cites W2168212656 @default.
• W2110450140 cites W2176524705 @default.
• W2110450140 cites W2992097690 @default.
• W2110450140 doi "https://doi.org/10.1016/j.cub.2007.11.043" @default.
• W2110450140 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18083516" @default.
• W2110450140 hasPublicationYear "2007" @default.
• W2110450140 type Work @default.
• W2110450140 sameAs 2110450140 @default.
• W2110450140 citedByCount "80" @default.
• W2110450140 countsByYear W21104501402012 @default.
• W2110450140 countsByYear W21104501402013 @default.
• W2110450140 countsByYear W21104501402014 @default.
• W2110450140 countsByYear W21104501402015 @default.
• W2110450140 countsByYear W21104501402016 @default.
• W2110450140 countsByYear W21104501402017 @default.
• W2110450140 countsByYear W21104501402018 @default.
• W2110450140 countsByYear W21104501402019 @default.
• W2110450140 countsByYear W21104501402020 @default.
• W2110450140 countsByYear W21104501402021 @default.
• W2110450140 countsByYear W21104501402022 @default.
• W2110450140 crossrefType "journal-article" @default.
• W2110450140 hasAuthorship W2110450140A5022575665 @default.
• W2110450140 hasAuthorship W2110450140A5024127282 @default.
• W2110450140 hasAuthorship W2110450140A5034616536 @default.
• W2110450140 hasAuthorship W2110450140A5036106086 @default.
• W2110450140 hasAuthorship W2110450140A5041690593 @default.
• W2110450140 hasAuthorship W2110450140A5042121734 @default.
• W2110450140 hasAuthorship W2110450140A5063752272 @default.
• W2110450140 hasAuthorship W2110450140A5076055146 @default.
• W2110450140 hasBestOaLocation W21104501401 @default.
• W2110450140 hasConcept C104317684 @default.
• W2110450140 hasConcept C127716648 @default.
• W2110450140 hasConcept C144024400 @default.
• W2110450140 hasConcept C149923435 @default.
• W2110450140 hasConcept C154945302 @default.
• W2110450140 hasConcept C167683757 @default.
• W2110450140 hasConcept C26207810 @default.
• W2110450140 hasConcept C2779473830 @default.
• W2110450140 hasConcept C2908647359 @default.
• W2110450140 hasConcept C41008148 @default.
• W2110450140 hasConcept C522857546 @default.
• W2110450140 hasConcept C54355233 @default.
• W2110450140 hasConcept C55493867 @default.
• W2110450140 hasConcept C68873052 @default.
• W2110450140 hasConcept C75268714 @default.
• W2110450140 hasConcept C78458016 @default.
• W2110450140 hasConcept C81917197 @default.
• W2110450140 hasConcept C83867959 @default.
• W2110450140 hasConcept C86803240 @default.
• W2110450140 hasConcept C90132467 @default.
• W2110450140 hasConceptScore W2110450140C104317684 @default.
• W2110450140 hasConceptScore W2110450140C127716648 @default.
• W2110450140 hasConceptScore W2110450140C144024400 @default.
• W2110450140 hasConceptScore W2110450140C149923435 @default.

• next