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• W2110475110 startingPage "2125" @default.
• W2110475110 abstract "Secreted proteases play integral roles in sexual reproduction in a broad range of taxa. In the genetic model Drosophila melanogaster, these molecules are thought to process peptides and activate enzymes inside female reproductive tracts, mediating critical postmating responses. A recent study of female reproductive tract proteins in the cactophilic fruit fly Drosophila arizonae, identified pervasive, lineage-specific gene duplication amongst secreted proteases. Here, we compare the evolutionary dynamics, biochemical nature, and physiological significance of secreted female reproductive serine endoproteases between D. arizonae and its congener D. melanogaster. We show that D. arizonae lower female reproductive tract (LFRT) proteins are significantly enriched for recently duplicated secreted proteases, particularly serine endoproteases, relative to D. melanogaster. Isolated lumen from D. arizonae LFRTs, furthermore, exhibits significant trypsin-like and elastase-like serine endoprotease acitivity, whereas no such activity is seen in D. melanogaster. Finally, trypsin- and elastase-like activity in D. arizonae female reproductive tracts is negatively regulated by mating. We propose that the intense proteolytic environment of the D. arizonae female reproductive tract relates to the extraordinary reproductive physiology of this species and that ongoing gene duplication amongst these proteases is an evolutionary consequence of sexual conflict." @default.
• W2110475110 created "2016-06-24" @default.
• W2110475110 creator A5032158361 @default.
• W2110475110 creator A5054380565 @default.
• W2110475110 date "2009-06-22" @default.
• W2110475110 modified "2023-10-15" @default.
• W2110475110 title "Protease Gene Duplication and Proteolytic Activity in Drosophila Female Reproductive Tracts" @default.
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• W2110475110 doi "https://doi.org/10.1093/molbev/msp121" @default.
• W2110475110 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2734159" @default.
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• W2110475110 hasPublicationYear "2009" @default.
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