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- W2110476061 abstract "Mouse natural killer T (NKT) cells with an invariant V alpha14-J alpha18 rearrangement (V alpha14 invariant [V alpha14i] NKT cells) are either CD4(+)CD8(-) or CD4(-)CD8(-). Because transgenic mice with forced CD8 expression in all T cells exhibited a profound NKT cell deficit, the absence of CD8 has been attributed to negative selection. We now present evidence that CD8 does not serve as a coreceptor for CD1d recognition and that the defect in development in CD8 transgene homozygous mice is the result of a reduction in secondary T cell receptor alpha rearrangements. Thymocytes from mice hemizygous for the CD8 transgene have a less severe rearrangement defect and have functional CD8(+) V alpha14i NKT cells. Furthermore, we demonstrate that the transcription factor Th, Poxviruses and Zinc finger, and Krüppel family (Th-POK) is expressed by V alpha14i NKT cells throughout their differentiation and is necessary both to silence CD8 expression and for the functional maturity of V alpha14i NKT cells. We therefore suggest that Th-POK expression is required for the normal development of V alpha14i NKT cells and that the absence of CD8 expression by these cells is a by-product of such expression, as opposed to the result of negative selection of CD8-expressing V alpha14i NKT cells." @default.
- W2110476061 created "2016-06-24" @default.
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- W2110476061 date "2010-04-19" @default.
- W2110476061 modified "2023-10-14" @default.
- W2110476061 title "Co-receptor choice by Vα14<i>i</i> NKT cells is driven by Th-POK expression rather than avoidance of CD8-mediated negative selection" @default.
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- W2110476061 doi "https://doi.org/10.1084/jem.20090557" @default.
- W2110476061 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2867285" @default.
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