FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110483604> ?p ?o ?g. }

• W2110483604 endingPage "55" @default.
• W2110483604 startingPage "49" @default.
• W2110483604 abstract "Background Many complications have been reported after orf infection, including lymphadenopathy, secondary bacterial infection, and erythema multiforme. Rare associations with papulovesicular eruptions, including a bullous pemphigoid-like eruption, have also been described. Objectives Our purpose was to clinically, histologically, and immunologically characterize two cases of orf-induced blistering disease, and to determine whether this condition represented a novel disease entity distinct from known immunobullous diseases. Methods Two patients were clinically described and skin biopsy specimens were collected for routine histology, direct immunofluorescence studies, and polymerase chain reaction analysis to detect orf viral DNA. Patients' sera were assessed for autoantibodies by indirect immunofluorescence studies using normal-appearing human salt-split skin, by Western blot analysis using keratinocyte extracts, dermal extracts, and recombinant type VII collagen, and immunoprecipitation studies of extracts from biosynthetically radiolabeled human keratinocytes. Results Two distinctive cases of severe, diffuse blistering eruptions after orf infection are described. In one patient, orf virus DNA was detected in the inciting orf lesion, but not in blistered skin, ruling out disseminated orf infection as a cause of the blisters. In both cases, histology revealed subepidermal blisters with mixed inflammatory cell infiltrates containing neutrophils and eosinophils, direct immunofluorescence microscopy studies demonstrated IgG and C3 deposited at the dermoepidermal junctions of perilesional skin, and indirect immunofluorescence studies demonstrated circulating antibasement membrane IgG that bound the dermal side of salt-split skin. Extensive immunoblot and immunoprecipitation studies failed to reveal a consistent, identifiable autoantigen. Limitations We describe only two cases. The autoantigen recognized by circulating autoantibodies was not identified. Conclusions Orf-induced immunobullous disease is a unique disease entity that is clinically and immunologically distinct from bullous pemphigoid, epidermolysis bullosa acquisita, and other known immunobullous conditions. Many complications have been reported after orf infection, including lymphadenopathy, secondary bacterial infection, and erythema multiforme. Rare associations with papulovesicular eruptions, including a bullous pemphigoid-like eruption, have also been described. Our purpose was to clinically, histologically, and immunologically characterize two cases of orf-induced blistering disease, and to determine whether this condition represented a novel disease entity distinct from known immunobullous diseases. Two patients were clinically described and skin biopsy specimens were collected for routine histology, direct immunofluorescence studies, and polymerase chain reaction analysis to detect orf viral DNA. Patients' sera were assessed for autoantibodies by indirect immunofluorescence studies using normal-appearing human salt-split skin, by Western blot analysis using keratinocyte extracts, dermal extracts, and recombinant type VII collagen, and immunoprecipitation studies of extracts from biosynthetically radiolabeled human keratinocytes. Two distinctive cases of severe, diffuse blistering eruptions after orf infection are described. In one patient, orf virus DNA was detected in the inciting orf lesion, but not in blistered skin, ruling out disseminated orf infection as a cause of the blisters. In both cases, histology revealed subepidermal blisters with mixed inflammatory cell infiltrates containing neutrophils and eosinophils, direct immunofluorescence microscopy studies demonstrated IgG and C3 deposited at the dermoepidermal junctions of perilesional skin, and indirect immunofluorescence studies demonstrated circulating antibasement membrane IgG that bound the dermal side of salt-split skin. Extensive immunoblot and immunoprecipitation studies failed to reveal a consistent, identifiable autoantigen. We describe only two cases. The autoantigen recognized by circulating autoantibodies was not identified. Orf-induced immunobullous disease is a unique disease entity that is clinically and immunologically distinct from bullous pemphigoid, epidermolysis bullosa acquisita, and other known immunobullous conditions." @default.
• W2110483604 created "2016-06-24" @default.
• W2110483604 creator A5006842195 @default.
• W2110483604 creator A5008621967 @default.
• W2110483604 creator A5010984764 @default.
• W2110483604 creator A5015905197 @default.
• W2110483604 creator A5031923633 @default.
• W2110483604 creator A5061830611 @default.
• W2110483604 creator A5063815398 @default.
• W2110483604 creator A5065566690 @default.
• W2110483604 creator A5075070858 @default.
• W2110483604 creator A5079232376 @default.
• W2110483604 creator A5080237247 @default.
• W2110483604 creator A5081965977 @default.
• W2110483604 creator A5019147320 @default.
• W2110483604 date "2008-01-01" @default.
• W2110483604 modified "2023-10-18" @default.
• W2110483604 title "Orf-induced immunobullous disease: A distinct autoimmune blistering disorder" @default.
• W2110483604 cites W1985475828 @default.
• W2110483604 cites W1998095088 @default.
• W2110483604 cites W2067111622 @default.
• W2110483604 cites W2110575658 @default.
• W2110483604 cites W4252969423 @default.
• W2110483604 cites W4255754280 @default.
• W2110483604 doi "https://doi.org/10.1016/j.jaad.2007.08.029" @default.
• W2110483604 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17919774" @default.
• W2110483604 hasPublicationYear "2008" @default.
• W2110483604 type Work @default.
• W2110483604 sameAs 2110483604 @default.
• W2110483604 citedByCount "34" @default.
• W2110483604 countsByYear W21104836042012 @default.
• W2110483604 countsByYear W21104836042013 @default.
• W2110483604 countsByYear W21104836042014 @default.
• W2110483604 countsByYear W21104836042015 @default.
• W2110483604 countsByYear W21104836042016 @default.
• W2110483604 countsByYear W21104836042017 @default.
• W2110483604 countsByYear W21104836042019 @default.
• W2110483604 countsByYear W21104836042021 @default.
• W2110483604 countsByYear W21104836042022 @default.
• W2110483604 countsByYear W21104836042023 @default.
• W2110483604 crossrefType "journal-article" @default.
• W2110483604 hasAuthorship W2110483604A5006842195 @default.
• W2110483604 hasAuthorship W2110483604A5008621967 @default.
• W2110483604 hasAuthorship W2110483604A5010984764 @default.
• W2110483604 hasAuthorship W2110483604A5015905197 @default.
• W2110483604 hasAuthorship W2110483604A5019147320 @default.
• W2110483604 hasAuthorship W2110483604A5031923633 @default.
• W2110483604 hasAuthorship W2110483604A5061830611 @default.
• W2110483604 hasAuthorship W2110483604A5063815398 @default.
• W2110483604 hasAuthorship W2110483604A5065566690 @default.
• W2110483604 hasAuthorship W2110483604A5075070858 @default.
• W2110483604 hasAuthorship W2110483604A5079232376 @default.
• W2110483604 hasAuthorship W2110483604A5080237247 @default.
• W2110483604 hasAuthorship W2110483604A5081965977 @default.
• W2110483604 hasConcept C142724271 @default.
• W2110483604 hasConcept C159654299 @default.
• W2110483604 hasConcept C163764329 @default.
• W2110483604 hasConcept C203014093 @default.
• W2110483604 hasConcept C2775934546 @default.
• W2110483604 hasConcept C2778075117 @default.
• W2110483604 hasConcept C2778236600 @default.
• W2110483604 hasConcept C2779252107 @default.
• W2110483604 hasConcept C2780439664 @default.
• W2110483604 hasConcept C2780949179 @default.
• W2110483604 hasConcept C2781320243 @default.
• W2110483604 hasConcept C57742111 @default.
• W2110483604 hasConcept C71924100 @default.
• W2110483604 hasConcept C98246554 @default.
• W2110483604 hasConceptScore W2110483604C142724271 @default.
• W2110483604 hasConceptScore W2110483604C159654299 @default.
• W2110483604 hasConceptScore W2110483604C163764329 @default.
• W2110483604 hasConceptScore W2110483604C203014093 @default.
• W2110483604 hasConceptScore W2110483604C2775934546 @default.
• W2110483604 hasConceptScore W2110483604C2778075117 @default.
• W2110483604 hasConceptScore W2110483604C2778236600 @default.
• W2110483604 hasConceptScore W2110483604C2779252107 @default.
• W2110483604 hasConceptScore W2110483604C2780439664 @default.
• W2110483604 hasConceptScore W2110483604C2780949179 @default.
• W2110483604 hasConceptScore W2110483604C2781320243 @default.
• W2110483604 hasConceptScore W2110483604C57742111 @default.
• W2110483604 hasConceptScore W2110483604C71924100 @default.
• W2110483604 hasConceptScore W2110483604C98246554 @default.
• W2110483604 hasIssue "1" @default.
• W2110483604 hasLocation W21104836041 @default.
• W2110483604 hasLocation W21104836042 @default.
• W2110483604 hasOpenAccess W2110483604 @default.
• W2110483604 hasPrimaryLocation W21104836041 @default.
• W2110483604 hasRelatedWork W191739 @default.
• W2110483604 hasRelatedWork W1969074690 @default.
• W2110483604 hasRelatedWork W2006662746 @default.
• W2110483604 hasRelatedWork W2014901103 @default.
• W2110483604 hasRelatedWork W2061307942 @default.
• W2110483604 hasRelatedWork W2071131391 @default.
• W2110483604 hasRelatedWork W2122130153 @default.
• W2110483604 hasRelatedWork W2398718032 @default.
• W2110483604 hasRelatedWork W2420728863 @default.
• W2110483604 hasRelatedWork W3028891664 @default.
• W2110483604 hasVolume "58" @default.

• next