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• W2110483912 abstract "ABSTRACT The new antitubercular drug candidate 2-[2- S -methyl-1,4-dioxa-8-azaspiro[4.5]dec-8-yl]-8-nitro-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one (BTZ043) targets the DprE1 (Rv3790) subunit of the enzyme decaprenylphosphoryl-β- d -ribose 2′-epimerase. To monitor the potential development of benzothiazinone (BTZ) resistance, a total of 240 sensitive and multidrug-resistant Mycobacterium tuberculosis clinical isolates from four European hospitals were surveyed for the presence of mutations in the dprE1 gene and for BTZ susceptibility. All 240 strains were susceptible, thus establishing the baseline prior to the introduction of BTZ043 in clinical trials." @default.
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• W2110483912 date "2010-04-01" @default.
• W2110483912 modified "2023-10-15" @default.
• W2110483912 title "Clinical Isolates of <i>Mycobacterium tuberculosis</i> in Four European Hospitals Are Uniformly Susceptible to Benzothiazinones" @default.
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• W2110483912 doi "https://doi.org/10.1128/aac.01676-09" @default.
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