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- W2110486027 abstract "Severe sepsis remains one of the most threatening conditions inintensive care. During the progression of sepsis from early hitto multiorgan failure proinflammatory and anti-inflammatorycytokines are released. Cytokines can be used as biomarkers todetermine the specific patterns of sepsis progression andassociation with mortality. These biomarkers were successfullyused as predictors in animal studies. Data from humans,especially comparison between children and adults, are limited.Hence, in this study we widely describe systemic cytokineresponse in this type of patient population. MethodsProspective study of 37 subjects (20 children, 17 adults)hospitalized with severe sepsis in intensive care. We measuredCRP, procalcitonin, TNF, IL-1beta, IL-4, IL-6, IL-8, IL-10,IL-12, TREM-1. ANOVA models were specified using Proc Mixed.Study was fully approved by an ethics committee. Results Weidentified a correlation of CRP levels with mortality orpresence of shock. We found a distinct feature of CRP in adultswith pronounced dynamic dichotomy in these subjects. Levels ofIL-6 were significantly different in adult patients in thecontext of shock states. High IL-6 levels in the beginning ofsepsis were associated with shock during progression ofillness. Highest risk of death was in adult patients associatedwith TREM-1 sustained high after 48 hours after sepsis onset.Otherwise, there was no correlation with death, shock statesand SOFA score for PCT, TNF, IL-1beta, IL-4, IL-8, IL-10, andIL-12. Response of circulating factors in patients with severesepsis is heterogeneous in the adult and children populationand has some distinct features according to the dynamics ofCRP, IL-6 and TREM-1." @default.
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- W2110486027 date "2010-03-01" @default.
- W2110486027 modified "2023-10-02" @default.
- W2110486027 title "Cytokine response in severe sepsis – Predicting and modelling the course of illness" @default.
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- W2110486027 doi "https://doi.org/10.1016/j.ijid.2010.02.437" @default.
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