FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110486997> ?p ?o ?g. }

• W2110486997 endingPage "4575" @default.
• W2110486997 startingPage "4569" @default.
• W2110486997 abstract "Abstract Nonrandom recurrent chromosomal abnormalities are ubiquitous in multiple myeloma (MM) and include, among others, translocations of the immunoglobulin heavy chain locus (IgH). IgH translocations in MM result in the up-regulation of oncogenes, and include more commonly t(11;14)(q13;q32), t(4;14)(p16;q32), and t(14;16)(q32;q23). Based on the recurrent nature of these translocations and their finding since the early stages of the plasma cell (PC) disorders, we hypothesized that they would confer biologic and clinical variability. In addition, deletions of 13q14 and 17p13 have also been associated with a shortened survival. We used cytoplasmic Ig—enhanced interphase fluorescent in situ hybridization to detect deletions (13q14 and 17p13.1), and translocations involving IgH in 351 patients treated with conventional chemotherapy entered into the Eastern Cooperative Oncology Group clinical trial E9486/9487. Translocations were frequently unbalanced with loss of one of the derivative chromosomes. The presence of t(4; 14)(p16;q32) (n = 42; 26 vs 45 months, P &lt; .001), t(14;16)(q32;q23) (n = 15; 16 vs 41 months, P = .003), – 17p13 (n = 37; 23 vs 44 months, P = .005), and – 13q14 (n = 176; 35 vs 51 months, P = .028) were associated with shorter survival. A stratification of patients into 3 distinct categories allowed for prognostication: poor prognosis group (t(4;14)(p16;q32), t(14; 16)(q32;q23), and – 17p13), intermediate prognosis (– 13q14), and good prognosis group (all others), with median survivals of 24.7, 42.3, and 50.5 months, respectively (P &lt; .001). This molecular cytogenetic classification identifies patients into poor, intermediate, and good risk categories. More importantly it provides further compelling evidence that MM is composed of subgroups of patients categorized according to their underlying genomic aberrations." @default.
• W2110486997 created "2016-06-24" @default.
• W2110486997 creator A5003015868 @default.
• W2110486997 creator A5009106148 @default.
• W2110486997 creator A5023193953 @default.
• W2110486997 creator A5025559326 @default.
• W2110486997 creator A5058232920 @default.
• W2110486997 creator A5064235771 @default.
• W2110486997 creator A5066792078 @default.
• W2110486997 creator A5067106221 @default.
• W2110486997 creator A5069347238 @default.
• W2110486997 creator A5072775789 @default.
• W2110486997 creator A5076999854 @default.
• W2110486997 creator A5080200072 @default.
• W2110486997 date "2003-06-01" @default.
• W2110486997 modified "2023-10-14" @default.
• W2110486997 title "Clinical and biologic implications of recurrent genomic aberrations in myeloma" @default.
• W2110486997 cites W138362336 @default.
• W2110486997 cites W1538098067 @default.
• W2110486997 cites W172192228 @default.
• W2110486997 cites W1777794242 @default.
• W2110486997 cites W180015230 @default.
• W2110486997 cites W1887989049 @default.
• W2110486997 cites W1918030391 @default.
• W2110486997 cites W1944291718 @default.
• W2110486997 cites W1966229399 @default.
• W2110486997 cites W1984534203 @default.
• W2110486997 cites W1985466592 @default.
• W2110486997 cites W1991188105 @default.
• W2110486997 cites W2010321586 @default.
• W2110486997 cites W2012958204 @default.
• W2110486997 cites W2042921949 @default.
• W2110486997 cites W2056013867 @default.
• W2110486997 cites W2059190311 @default.
• W2110486997 cites W2059494778 @default.
• W2110486997 cites W2075175917 @default.
• W2110486997 cites W2078469945 @default.
• W2110486997 cites W2084657347 @default.
• W2110486997 cites W2086918627 @default.
• W2110486997 cites W2091571321 @default.
• W2110486997 cites W2103101762 @default.
• W2110486997 cites W2103209498 @default.
• W2110486997 cites W2104634390 @default.
• W2110486997 cites W2111059976 @default.
• W2110486997 cites W2127096655 @default.
• W2110486997 cites W2147609534 @default.
• W2110486997 cites W2150498320 @default.
• W2110486997 cites W2171263152 @default.
• W2110486997 cites W2187668060 @default.
• W2110486997 cites W2413123323 @default.
• W2110486997 cites W2428771541 @default.
• W2110486997 cites W4248493569 @default.
• W2110486997 cites W4252684946 @default.
• W2110486997 cites W4293241248 @default.
• W2110486997 cites W4301341292 @default.
• W2110486997 cites W59035496 @default.
• W2110486997 doi "https://doi.org/10.1182/blood-2002-10-3017" @default.
• W2110486997 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12576322" @default.
• W2110486997 hasPublicationYear "2003" @default.
• W2110486997 type Work @default.
• W2110486997 sameAs 2110486997 @default.
• W2110486997 citedByCount "594" @default.
• W2110486997 countsByYear W21104869972012 @default.
• W2110486997 countsByYear W21104869972013 @default.
• W2110486997 countsByYear W21104869972014 @default.
• W2110486997 countsByYear W21104869972015 @default.
• W2110486997 countsByYear W21104869972016 @default.
• W2110486997 countsByYear W21104869972017 @default.
• W2110486997 countsByYear W21104869972018 @default.
• W2110486997 countsByYear W21104869972019 @default.
• W2110486997 countsByYear W21104869972020 @default.
• W2110486997 countsByYear W21104869972021 @default.
• W2110486997 countsByYear W21104869972022 @default.
• W2110486997 countsByYear W21104869972023 @default.
• W2110486997 crossrefType "journal-article" @default.
• W2110486997 hasAuthorship W2110486997A5003015868 @default.
• W2110486997 hasAuthorship W2110486997A5009106148 @default.
• W2110486997 hasAuthorship W2110486997A5023193953 @default.
• W2110486997 hasAuthorship W2110486997A5025559326 @default.
• W2110486997 hasAuthorship W2110486997A5058232920 @default.
• W2110486997 hasAuthorship W2110486997A5064235771 @default.
• W2110486997 hasAuthorship W2110486997A5066792078 @default.
• W2110486997 hasAuthorship W2110486997A5067106221 @default.
• W2110486997 hasAuthorship W2110486997A5069347238 @default.
• W2110486997 hasAuthorship W2110486997A5072775789 @default.
• W2110486997 hasAuthorship W2110486997A5076999854 @default.
• W2110486997 hasAuthorship W2110486997A5080200072 @default.
• W2110486997 hasBestOaLocation W21104869971 @default.
• W2110486997 hasConcept C104317684 @default.
• W2110486997 hasConcept C126322002 @default.
• W2110486997 hasConcept C138626823 @default.
• W2110486997 hasConcept C143998085 @default.
• W2110486997 hasConcept C203014093 @default.
• W2110486997 hasConcept C2776364478 @default.
• W2110486997 hasConcept C2777542201 @default.
• W2110486997 hasConcept C30481170 @default.
• W2110486997 hasConcept C54355233 @default.
• W2110486997 hasConcept C71924100 @default.

• next