FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110491323> ?p ?o ?g. }

• W2110491323 endingPage "410" @default.
• W2110491323 startingPage "405" @default.
• W2110491323 abstract "Calcitonin gene-related peptide (CGRP), a potent vasodilator released from a subset of sensory Adelta- and C-fiber afferents, has been suggested to play a beneficial role in myocardial ischemia. The aim of the present study was to investigate some receptors possibly involved in the proton-mediated CGRP release from the heart.CGRP release from freshly isolated hearts of mice lacking the capsaicin receptor (TRPV1-/-), the bradykinin receptor type 2 (B2-/-), or the acid-sensing ion channel type 3 (ASIC3-/-) and their wild-type littermates (TRPV1+/+, B2+/+, ASIC3+/+) were compared. Hearts were passed through a series of solutions based on oxygenated synthetic interstitial fluid (SIF). SIF buffered to pH 5.7 or 5.2 was used as an acidic test stimulus, and capsaicin (5x10(-7) M) was finally applied as a positive control. All eluates were processed using an enzyme immunoassay (EIA) for measurement of CGRP concentrations.SIF at pH 5.7 and 5.2 caused significant increases in CGRP release in TRPV1+/+ but not in mice lacking the TRPV1 receptor. The same acid stimuli caused no significant differences in CGRP release between ASIC3+/+ and ASIC3-/- or between B2+/+ and B2-/-, respectively. Capsaicin caused massive CGRP release in all mouse genotypes with the exception of TRPV1-/-.We conclude that cardiac acidosis is a strong stimulus to release CGRP from the mouse heart. This effect seems to be primarily mediated through activation of TRPV1 receptors that are known to be expressed by slowly conducting nociceptive primary afferent nerve fibers." @default.
• W2110491323 created "2016-06-24" @default.
• W2110491323 creator A5026365585 @default.
• W2110491323 creator A5044049622 @default.
• W2110491323 creator A5072996355 @default.
• W2110491323 creator A5091196503 @default.
• W2110491323 date "2005-02-01" @default.
• W2110491323 modified "2023-09-27" @default.
• W2110491323 title "Role of different proton-sensitive channels in releasing calcitonin gene-related peptide from isolated hearts of mutant mice" @default.
• W2110491323 cites W1511198581 @default.
• W2110491323 cites W1974642350 @default.
• W2110491323 cites W1990049510 @default.
• W2110491323 cites W1990636755 @default.
• W2110491323 cites W1992358268 @default.
• W2110491323 cites W1993576134 @default.
• W2110491323 cites W1995705528 @default.
• W2110491323 cites W1998043430 @default.
• W2110491323 cites W1999164189 @default.
• W2110491323 cites W2019865493 @default.
• W2110491323 cites W2023486326 @default.
• W2110491323 cites W2033576768 @default.
• W2110491323 cites W2038513066 @default.
• W2110491323 cites W2048518451 @default.
• W2110491323 cites W2050781058 @default.
• W2110491323 cites W2053277833 @default.
• W2110491323 cites W2066415438 @default.
• W2110491323 cites W2070049849 @default.
• W2110491323 cites W2073133096 @default.
• W2110491323 cites W2074247245 @default.
• W2110491323 cites W2079116886 @default.
• W2110491323 cites W2085049416 @default.
• W2110491323 cites W2092433412 @default.
• W2110491323 cites W2092744441 @default.
• W2110491323 cites W2107705149 @default.
• W2110491323 cites W2122332943 @default.
• W2110491323 cites W2134742719 @default.
• W2110491323 cites W2141986650 @default.
• W2110491323 cites W2202734803 @default.
• W2110491323 cites W2231183697 @default.
• W2110491323 cites W2313630045 @default.
• W2110491323 cites W2337458623 @default.
• W2110491323 cites W2410758126 @default.
• W2110491323 cites W2470047386 @default.
• W2110491323 cites W1967473058 @default.
• W2110491323 doi "https://doi.org/10.1016/j.cardiores.2004.10.013" @default.
• W2110491323 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15639479" @default.
• W2110491323 hasPublicationYear "2005" @default.
• W2110491323 type Work @default.
• W2110491323 sameAs 2110491323 @default.
• W2110491323 citedByCount "38" @default.
• W2110491323 countsByYear W21104913232013 @default.
• W2110491323 countsByYear W21104913232014 @default.
• W2110491323 countsByYear W21104913232015 @default.
• W2110491323 countsByYear W21104913232016 @default.
• W2110491323 countsByYear W21104913232017 @default.
• W2110491323 countsByYear W21104913232018 @default.
• W2110491323 crossrefType "journal-article" @default.
• W2110491323 hasAuthorship W2110491323A5026365585 @default.
• W2110491323 hasAuthorship W2110491323A5044049622 @default.
• W2110491323 hasAuthorship W2110491323A5072996355 @default.
• W2110491323 hasAuthorship W2110491323A5091196503 @default.
• W2110491323 hasBestOaLocation W21104913231 @default.
• W2110491323 hasConcept C118303440 @default.
• W2110491323 hasConcept C126322002 @default.
• W2110491323 hasConcept C134018914 @default.
• W2110491323 hasConcept C155164980 @default.
• W2110491323 hasConcept C160145004 @default.
• W2110491323 hasConcept C163170386 @default.
• W2110491323 hasConcept C170493617 @default.
• W2110491323 hasConcept C185592680 @default.
• W2110491323 hasConcept C2779591629 @default.
• W2110491323 hasConcept C2779627488 @default.
• W2110491323 hasConcept C2780051329 @default.
• W2110491323 hasConcept C71924100 @default.
• W2110491323 hasConcept C86803240 @default.
• W2110491323 hasConceptScore W2110491323C118303440 @default.
• W2110491323 hasConceptScore W2110491323C126322002 @default.
• W2110491323 hasConceptScore W2110491323C134018914 @default.
• W2110491323 hasConceptScore W2110491323C155164980 @default.
• W2110491323 hasConceptScore W2110491323C160145004 @default.
• W2110491323 hasConceptScore W2110491323C163170386 @default.
• W2110491323 hasConceptScore W2110491323C170493617 @default.
• W2110491323 hasConceptScore W2110491323C185592680 @default.
• W2110491323 hasConceptScore W2110491323C2779591629 @default.
• W2110491323 hasConceptScore W2110491323C2779627488 @default.
• W2110491323 hasConceptScore W2110491323C2780051329 @default.
• W2110491323 hasConceptScore W2110491323C71924100 @default.
• W2110491323 hasConceptScore W2110491323C86803240 @default.
• W2110491323 hasIssue "2" @default.
• W2110491323 hasLocation W21104913231 @default.
• W2110491323 hasLocation W21104913232 @default.
• W2110491323 hasOpenAccess W2110491323 @default.
• W2110491323 hasPrimaryLocation W21104913231 @default.
• W2110491323 hasRelatedWork W1547687776 @default.
• W2110491323 hasRelatedWork W2023079616 @default.
• W2110491323 hasRelatedWork W2085871851 @default.
• W2110491323 hasRelatedWork W2110491323 @default.
• W2110491323 hasRelatedWork W2116319226 @default.

• next