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• W2110493055 endingPage "891" @default.
• W2110493055 startingPage "881" @default.
• W2110493055 abstract "The objectives of this study were to investigate: (1) the antibacterial activity of two antibacterial monomers, dimethylaminododecyl methacrylate (DMADDM) and dimethylammoniumethyl dimethacrylate (DMAEDM), against eight different species of oral pathogens for the first time; (2) the cytotoxicity of DMAEDM and DMADDM.DMAEDM and DMADDM were synthesized by reacting a tertiary amine group with an organo-halide. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) against eight species of bacteria were tested. Time-kill determinations were performed to examine the bactericidal kinetics. Cytotoxicity of monomers on human gingival fibroblasts (HGF) was assessed using a methyl thiazolyltetrazolium assay and live/dead viability assay.DMADDM showed strong bactericidal activity against all bacteria, with MIC of 1.2-9.8μg/mL. DMAEDM had MIC of 20-80mg/mL. Time-kill determinations indicated that DMADDM and DMAEDM had rapid killing effects against eight species of bacteria, and eliminated all bacteria in 30min at the concentration of 4-fold MBC. Median lethal concentration for DMADDM and DMAEDM was between 20 and 40μg/mL, which was 20-fold higher than 1-2μg/mL for BisGMA control.DMAEDM and DMADDM were tested in time-kill assay against eight species of oral bacteria for the first time. Both were effective in bacteria-inhibition, but DMADDM had a higher potency than DMAEDM. Different killing efficacy was found against different bacteria species. DMAEDM and DMADDM had much lower cytotoxicity than BisGMA. Therefore, DMADDM and DMAEDM are promising for use in bonding agents and other restorative/preventive materials to combat a variety of oral pathogens." @default.
• W2110493055 created "2016-06-24" @default.
• W2110493055 creator A5006690496 @default.
• W2110493055 creator A5008911744 @default.
• W2110493055 creator A5061900770 @default.
• W2110493055 creator A5088320537 @default.
• W2110493055 date "2013-10-01" @default.
• W2110493055 modified "2023-10-16" @default.
• W2110493055 title "Time-kill behaviour against eight bacterial species and cytotoxicity of antibacterial monomers" @default.
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• W2110493055 doi "https://doi.org/10.1016/j.jdent.2013.07.006" @default.
• W2110493055 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3845446" @default.
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• W2110493055 hasPublicationYear "2013" @default.
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