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• W2110502007 abstract "Cutting the axon of a morphologically polarized neuron (stage 3) close to the cell body causes another neurite to grow as an axon [1Dotti CG Banker GA Experimentally induced alteration in the polarity of developing neurons.Nature. 1987; 330: 254-256Crossref PubMed Scopus (210) Google Scholar, 2Goslin K Banker G Experimental observation on the development of polarity by hippocampal neurons in culture.J Cell Biol. 1989; 108: 1507-1516Crossref PubMed Scopus (325) Google Scholar, 3Bradke F Dotti CG Neuronal polarity: vectorial cytoplasmic flow precedes axon formation.Neuron. 1997; 19: 1175-1186Abstract Full Text Full Text PDF PubMed Scopus (190) Google Scholar]. Stage 3 neurons still lack molecular segregation of axonal and dendritic proteins, however. Axonal and dendritic compartments acquire their distinct composition at stage 4 (4–5days in culture), when proteins such as the microtubule-associated protein 2 (MAP-2) and the glutamate receptor subunit GluR1 localize to the dendrites and disappear from the axon [4Craig AM Blackstone CD Huganir RL Banker G The distribution of glutamate receptors in cultured rat hippocampal neurons: postsynaptic clustering of AMPA-selective subunits.Neuron. 1993; 10: 1055-1068Abstract Full Text PDF PubMed Scopus (293) Google Scholar, 5Caceres A Banker GA Binder L Immunocytochemical localization of tubulin and microtubule-associated protein 2 during the development of hippocampal neurons in culture.J Neurosci. 1986; 6: 714-722Crossref PubMed Google Scholar]. We investigated whether cultured hippocampal neurons retained axon/dendrite plasticity after axons and dendrites have created their distinct cytoskeletal architecture and acquired their specific membrane composition. We found that axotomy of stage 4 neurons transformed a dendrite into an axon. Using axonal and dendritic markers, we tested whether cytoskeletal changes could cause similar transformations, and found that actin depolymerization induced multiple axons in unpolarized neurons. Moreover, depletion of actin filaments from both morphologically and molecularly polarized cells also resulted in the growth of multiple axons from pre-existing dendrites. These results imply that dendrites retain the potential to become axons even after molecular segregation has occurred and that the dendritic fate depends on the integrity of the actin cytoskeleton." @default.
• W2110502007 created "2016-06-24" @default.
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• W2110502007 date "2000-11-01" @default.
• W2110502007 modified "2023-10-17" @default.
• W2110502007 title "Differentiated neurons retain the capacity to generate axons from dendrites" @default.
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• W2110502007 doi "https://doi.org/10.1016/s0960-9822(00)00807-1" @default.
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